Development Level

Tbio 89 | 11,651
Tdark 15 | 6,593
Tchem 13 | 1,388
Tclin 5 | 612

Collection

Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37
RFA-RM-18-021 1 | 328

IMPC Phenotype

increased circulating alkaline... 122 | 122
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 82 | 11,493
ovarian cancer 69 | 8,520
psoriasis 61 | 6,694
glioblastoma 59 | 5,792
osteosarcoma 58 | 7,950
medulloblastoma, large-cell 57 | 6,241
atypical teratoid / rhabdoid tumor 50 | 5,112
ependymoma 43 | 4,679
lung cancer 41 | 4,740
Astrocytoma, Pilocytic 39 | 3,081
adult high grade glioma 36 | 3,801
group 3 medulloblastoma 35 | 4,104
primitive neuroectodermal tumor 35 | 3,035
malignant mesothelioma 31 | 3,232
astrocytic glioma 29 | 2,597
Breast cancer 28 | 3,578
oligodendroglioma 28 | 2,850
subependymal giant cell astrocytoma 28 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
invasive ductal carcinoma 27 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
lung adenocarcinoma 23 | 2,716
Cancer 22 | 2,499
Pick disease 22 | 1,894
non-small cell lung cancer 20 | 2,890
pituitary cancer 20 | 1,972
Autosomal recessive predisposition 17 | 1,442
Kidney cancer 17 | 2,613
lung carcinoma 17 | 2,843
breast carcinoma 15 | 1,638
tuberculosis 15 | 2,010
Intellectual disability 14 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Schizophrenia 13 | 1,160
ductal carcinoma in situ 13 | 1,745
group 4 medulloblastoma 13 | 1,855
pancreatic cancer 13 | 2,398
pediatric high grade glioma 13 | 1,064
ulcerative colitis 13 | 1,819
Obesity 12 | 678
adrenocortical carcinoma 12 | 1,428
colon cancer 12 | 1,478
cystic fibrosis 12 | 1,696
spina bifida 12 | 1,074
diabetes mellitus 11 | 1,728
non primary Sjogren syndrome sicca 11 | 891
Epilepsy 10 | 792
active ulcerative colitis 10 | 764
acute quadriplegic myopathy 10 | 1,158
interstitial cystitis 10 | 2,312
Bipolar Disorder 9 | 666
primary pancreatic ductal adenocarcinoma 9 | 1,109
Multiple myeloma 8 | 1,332
Rheumatoid arthritis 8 | 1,191
Seizures 8 | 596
Short stature 8 | 531
active Crohn's disease 8 | 922
aldosterone-producing adenoma 8 | 665
cutaneous lupus erythematosus 8 | 1,057
Alzheimer's disease 7 | 658
Atopic dermatitis 7 | 952
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Hepatomegaly 7 | 285
Mental and motor retardation 7 | 608
Muscle hypotonia 7 | 571
Parkinson's disease 7 | 392
Vascular disease 7 | 319
acute myeloid leukemia 7 | 783
juvenile dermatomyositis 7 | 1,187
nasopharyngeal carcinoma 7 | 1,058
Cleft Palate 6 | 271
Constipation 6 | 181
Dull intelligence 6 | 645
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Prostatic Neoplasms 6 | 495
Sensorineural Hearing Loss (disorder) 6 | 284
Uranostaphyloschisis 6 | 167
astrocytoma 6 | 1,146
esophageal adenocarcinoma 6 | 737
gastric carcinoma 6 | 807
progressive supranuclear palsy 6 | 676
Cataract 5 | 297
Depressive disorder 5 | 409
Down syndrome 5 | 499
Endometriosis 5 | 540
Hyperreflexia 5 | 209
Hypertension 5 | 396
Hypertensive disease 5 | 292
Kidney disease 5 | 430
Liver cancer 5 | 604
Small head 5 | 374
Stomach Neoplasms 5 | 300
dermatomyositis 5 | 966
hepatocellular carcinoma 5 | 547
mucosa-associated lymphoid tissue lymphoma 5 | 484

Tissue

Endocrine System 120 | 18,159
Digestive Tract 116 | 17,369
Male tissues 116 | 17,142
Blood and immune system 115 | 16,909
Female tissues 115 | 17,400
Skin and soft tissues 115 | 17,230
Liver and Pancreas 113 | 16,750
Respiratory system 113 | 16,393
Nervous System 112 | 16,725
Urinary Tract 112 | 16,678
Cardiovascular System 106 | 15,192

Target Family

Non-IDG 65 | 12,091
Enzyme 29 | 4,145
Transcription Factor 10 | 1,400
Kinase 6 | 634
Transporter 5 | 473
Epigenetic 4 | 242
GPCR 1 | 408
Ion Channel 1 | 344
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Yae1 domain-containing protein 1 YAE1D1 Tdark Non-IDG 0.26 0.54 89
Basic leucine zipper and W2 domain-containing protein 2 BZW2 Tbio Non-IDG -0.20261 1.21 83
KICSTOR complex protein kaptin KPTN Tbio Non-IDG -1.45875 26.8 153
5'-AMP-activated protein kinase subunit beta-1 PRKAB1 Tbio Kinase -1.52519 32.5 532
HBS1-like protein HBS1L Tbio Non-IDG -2.55785 357.2 263
T-box transcription factor TBX22 TBX22 Tbio Transcription Factor -2.14590 142.1 138
Tropomodulin-1 TMOD1 Tbio Non-IDG -1.84485 74.1 155
Protein Hook homolog 3 HOOK3 Tbio Non-IDG -1.22079 6.06 60
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 TNFAIP1 Tbio Non-IDG -1.31215 21.6 197
RNA-binding motif protein, X chromosome RBMX Tbio Non-IDG -1.52402 35.8 98