Development Level

Tbio 51 | 11,445
Tchem 12 | 1,598
Tdark 10 | 6,588
Tclin 7 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

increased circulating HDL chol... 80 | 80
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 54 | 11,493
ovarian cancer 42 | 8,520
osteosarcoma 35 | 7,950
glioblastoma 33 | 5,792
medulloblastoma, large-cell 32 | 6,241
atypical teratoid / rhabdoid tumor 29 | 5,112
psoriasis 28 | 6,694
ependymoma 24 | 4,679
invasive ductal carcinoma 24 | 2,951
lung cancer 23 | 4,740
Breast cancer 22 | 3,578
adult high grade glioma 20 | 3,801
Astrocytoma, Pilocytic 19 | 3,081
Cancer 19 | 2,499
group 3 medulloblastoma 18 | 4,104
lung adenocarcinoma 18 | 2,716
primitive neuroectodermal tumor 18 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
non-small cell lung cancer 16 | 2,890
Kidney cancer 15 | 2,613
group 4 medulloblastoma 15 | 1,855
breast carcinoma 14 | 1,638
malignant mesothelioma 14 | 3,232
pancreatic cancer 14 | 2,398
ductal carcinoma in situ 13 | 1,745
lung carcinoma 13 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
tuberculosis 11 | 2,010
cystic fibrosis 10 | 1,696
diabetes mellitus 10 | 1,728
pituitary cancer 10 | 1,972
subependymal giant cell astrocytoma 10 | 2,287
active Crohn's disease 9 | 922
adrenocortical carcinoma 9 | 1,428
astrocytic glioma 9 | 2,597
cutaneous lupus erythematosus 9 | 1,057
interstitial cystitis 9 | 2,312
juvenile dermatomyositis 9 | 1,187
pediatric high grade glioma 9 | 1,064
Intellectual disability 8 | 1,016
non primary Sjogren syndrome sicca 8 | 891
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
primary pancreatic ductal adenocarcinoma 8 | 1,109
Autosomal recessive predisposition 7 | 1,442
Breast Neoplasms 7 | 445
Mammary Neoplasms 7 | 425
Multiple myeloma 7 | 1,332
Polycystic ovary syndrome 7 | 360
Vascular disease 7 | 319
oligodendroglioma 7 | 2,850
primary Sjogren syndrome 7 | 735
ulcerative colitis 7 | 1,819
Atopic dermatitis 6 | 952
Fatty liver disease 6 | 103
Obesity 6 | 678
Pick disease 6 | 1,894
dermatomyositis 6 | 966
spina bifida 6 | 1,074
Dull intelligence 5 | 645
Hypertensive disease 5 | 292
Kidney disease 5 | 430
Liver Cirrhosis, Experimental 5 | 769
Liver cancer 5 | 604
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Osteoporosis 5 | 363
Poor school performance 5 | 645
Rheumatoid arthritis 5 | 1,191
Schizophrenia 5 | 1,160
acute myeloid leukemia 5 | 783
colon cancer 5 | 1,478
inflammatory breast cancer 5 | 286
nasopharyngeal carcinoma 5 | 1,058
Cognitive delay 4 | 608
Delayed Puberty 4 | 97
Endometriosis 4 | 540
Global developmental delay 4 | 608
Hypertension 4 | 396
Mental and motor retardation 4 | 608
Microcephaly 4 | 166
Parkinson's disease 4 | 392
Short stature 4 | 531
Small testicle 4 | 75
active ulcerative colitis 4 | 764
astrocytoma 4 | 1,146
medulloblastoma 4 | 720
urothelial carcinoma 4 | 318
Alzheimer's disease 3 | 658
Bipolar Disorder 3 | 666
Down syndrome 3 | 499
Waldenstrons macroglobulinemia 3 | 765
fibroadenoma 3 | 559
gastric carcinoma 3 | 807
hepatocellular carcinoma 3 | 547
mucosa-associated lymphoid tissue lymphoma 3 | 484
nephrosclerosis 3 | 333
pancreatic carcinoma 3 | 562
progressive supranuclear palsy 3 | 676

Tissue

Digestive Tract 76 | 17,369
Endocrine System 76 | 18,159
Blood and immune system 74 | 16,909
Female tissues 73 | 17,400
Liver and Pancreas 73 | 16,750
Male tissues 73 | 17,142
Skin and soft tissues 73 | 17,230
Urinary Tract 72 | 16,678
Nervous System 70 | 16,725
Respiratory system 69 | 16,393
Cardiovascular System 66 | 15,192

Target Family

Non-IDG 45 | 12,091
Enzyme 17 | 4,145
Epigenetic 5 | 242
Kinase 4 | 634
Transporter 4 | 473
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38
GPCR 1 | 408

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone deacetylase 1 HDAC1 Tclin Epigenetic -3.03775 954.3 1201
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.06808 938.9 585
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tchem Kinase -2.12399 119.4 334
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.43459 26.5 198
78 kDa glucose-regulated protein HSPA5 Tchem Non-IDG -3.35010 2184.4 1074
DNA (cytosine-5)-methyltransferase 3A DNMT3A Tclin Epigenetic -2.91291 722.8 693
Leptin receptor LEPR Tclin Non-IDG -3.01833 782.6 615
ATP-binding cassette sub-family G member 2 ABCG2 Tchem Transporter -3.41877 2731.1 246