Development Level

Tbio 56 | 11,651
Tdark 9 | 6,593
Tclin 4 | 612
Tchem 3 | 1,388

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

increased bone mineral density 72 | 72
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 54 | 11,493
ovarian cancer 43 | 8,520
osteosarcoma 42 | 7,950
lung cancer 33 | 4,740
glioblastoma 32 | 5,792
medulloblastoma, large-cell 32 | 6,241
atypical teratoid / rhabdoid tumor 27 | 5,112
psoriasis 27 | 6,694
ependymoma 24 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
group 3 medulloblastoma 19 | 4,104
primitive neuroectodermal tumor 19 | 3,035
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Pick disease 17 | 1,894
adult high grade glioma 17 | 3,801
Astrocytoma, Pilocytic 16 | 3,081
Breast cancer 16 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
malignant mesothelioma 16 | 3,232
lung adenocarcinoma 15 | 2,716
Cancer 14 | 2,499
group 4 medulloblastoma 14 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
oligodendroglioma 14 | 2,850
juvenile dermatomyositis 13 | 1,187
lung carcinoma 13 | 2,843
tuberculosis 13 | 2,010
acute quadriplegic myopathy 12 | 1,158
astrocytic glioma 12 | 2,597
invasive ductal carcinoma 12 | 2,951
pancreatic cancer 12 | 2,398
pituitary cancer 12 | 1,972
Kidney cancer 11 | 2,613
Rheumatoid arthritis 11 | 1,191
cystic fibrosis 11 | 1,696
non-small cell lung cancer 11 | 2,890
breast carcinoma 10 | 1,638
subependymal giant cell astrocytoma 10 | 2,287
Autosomal recessive predisposition 9 | 1,442
astrocytoma 9 | 1,146
colon cancer 9 | 1,478
ductal carcinoma in situ 9 | 1,745
ulcerative colitis 9 | 1,819
Intellectual disability 8 | 1,016
adrenocortical carcinoma 8 | 1,428
gastric carcinoma 8 | 807
interstitial cystitis 8 | 2,312
pediatric high grade glioma 8 | 1,064
Duchenne muscular dystrophy 7 | 601
Muscle hypotonia 7 | 571
Schizophrenia 7 | 1,160
active ulcerative colitis 7 | 764
acute myeloid leukemia 7 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
dermatomyositis 7 | 966
progressive supranuclear palsy 7 | 676
spina bifida 7 | 1,074
Seizures 6 | 596
Short stature 6 | 531
Small head 6 | 374
non primary Sjogren syndrome sicca 6 | 891
primary pancreatic ductal adenocarcinoma 6 | 1,109
Cognitive delay 5 | 608
Epilepsy 5 | 792
Global developmental delay 5 | 608
Liver Cirrhosis, Experimental 5 | 769
Liver cancer 5 | 604
Mental and motor retardation 5 | 608
Nystagmus 5 | 317
diabetes mellitus 5 | 1,728
primary Sjogren syndrome 5 | 735
tuberculosis and treatment for 6 months 5 | 409
Alzheimer's disease 4 | 658
Atopic dermatitis 4 | 952
Broad flat nasal bridge 4 | 236
Dull intelligence 4 | 645
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple myeloma 4 | 1,332
Nasal bridge wide 4 | 236
Obesity 4 | 678
Osteoporosis 4 | 363
Parkinson's disease 4 | 392
Polycystic ovary syndrome 4 | 360
Poor school performance 4 | 645
Respiratory Insufficiency 4 | 132
Waldenstrons macroglobulinemia 4 | 765
hereditary spastic paraplegia 4 | 318
medulloblastoma 4 | 720
nasopharyngeal carcinoma 4 | 1,058
nephrosclerosis 4 | 333
Becker muscular dystrophy 3 | 191
Down syndrome 3 | 499
Endometriosis 3 | 540
Myocardial Ischemia 3 | 169
aldosterone-producing adenoma 3 | 665
esophageal adenocarcinoma 3 | 737
non diabetic and post-ischemic heart failure 3 | 200
sonic hedgehog group medulloblastoma 3 | 467

Tissue

Blood and immune system 71 | 16,909
Digestive Tract 71 | 17,369
Endocrine System 71 | 18,159
Female tissues 71 | 17,400
Nervous System 71 | 16,725
Respiratory system 71 | 16,393
Cardiovascular System 70 | 15,192
Liver and Pancreas 70 | 16,750
Male tissues 70 | 17,142
Skin and soft tissues 70 | 17,230
Urinary Tract 69 | 16,678

Target Family

Non-IDG 32 | 12,091
Enzyme 15 | 4,145
Transcription Factor 8 | 1,400
Kinase 7 | 634
Epigenetic 5 | 242
Transporter 3 | 473
Nuclear Receptor 2 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555
DNA (cytosine-5)-methyltransferase 3A DNMT3A Tclin Epigenetic -2.91291 722.8 693
BRISC and BRCA1-A complex member 2 BABAM2 Tbio Non-IDG -1.84649 70.2 156
Spindlin-1 SPIN1 Tbio Non-IDG -2.02987 109.3 128
Synaptic vesicle membrane protein VAT-1 homolog-like VAT1L Tdark Enzyme 0.18 0.50 92
ADP-dependent glucokinase ADPGK Tbio Kinase -0.86342 7.82 154
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 TNFAIP1 Tbio Non-IDG -1.31215 21.6 197
Phospholipase DDHD1 DDHD1 Tbio Enzyme -1.23443 15.3 31
Tumor necrosis factor receptor superfamily member 9 TNFRSF9 Tbio Non-IDG -2.83886 770.0 684
DNA-binding protein SATB1 SATB1 Tbio Transcription Factor -2.28849 219.7 322