Development Level

Tbio 12 | 10,625
Tchem 4 | 1,890
Tdark 4 | 7,003

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

increased body length 20 | 20
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 12 | 8,492
osteosarcoma 9 | 7,933
psoriasis 9 | 6,685
lung adenocarcinoma 7 | 2,714
lung cancer 7 | 4,473
glioblastoma 6 | 5,572
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
Breast cancer 5 | 3,099
Cancer 5 | 2,346
invasive ductal carcinoma 5 | 2,950
medulloblastoma, large-cell 5 | 6,234
pancreatic cancer 5 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
pilocytic astrocytoma 5 | 3,086
subependymal giant cell astrocytoma 5 | 2,287
Carcinoma 4 | 2,147
Multiple myeloma 4 | 1,328
Pick disease 4 | 1,893
ductal carcinoma in situ 4 | 1,745
group 3 medulloblastoma 4 | 2,254
group 4 medulloblastoma 4 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
lung carcinoma 4 | 2,844
non-small cell lung cancer 4 | 2,798
primitive neuroectodermal tumor 4 | 3,031
ulcerative colitis 4 | 2,087
Alzheimer's disease 3 | 644
Rheumatoid Arthritis 3 | 1,171
adrenocortical carcinoma 3 | 1,427
atypical teratoid / rhabdoid tumor 3 | 4,369
breast carcinoma 3 | 1,614
hepatocellular carcinoma 3 | 550
juvenile dermatomyositis 3 | 1,189
posterior fossa group B ependymoma 3 | 1,530
tuberculosis 3 | 1,563
Duchenne muscular dystrophy 2 | 602
IGA Glomerulonephritis 2 | 454
Neurodegenerative disease 2 | 383
Pain 2 | 70
Schizophrenia 2 | 503
Vascular disease 2 | 281
adult high grade glioma 2 | 2,148
astrocytoma 2 | 1,493
cystic fibrosis 2 | 1,670
diabetes mellitus 2 | 1,663
esophageal adenocarcinoma 2 | 737
interstitial cystitis 2 | 2,299
malignant mesothelioma 2 | 3,163
mucosa-associated lymphoid tissue lymphoma 2 | 480
pancreatic carcinoma 2 | 567
pediatric high grade glioma 2 | 2,712
pituitary cancer 2 | 1,972
posterior fossa group A ependymoma 2 | 1,511
primary pancreatic ductal adenocarcinoma 2 | 1,271
sarcoidosis 2 | 368
sonic hedgehog group medulloblastoma 2 | 1,482
tuberculosis and treatment for 6 months 2 | 686
Acquired metabolic disease 1 | 267
Alcohol dependence 1 | 107
Animal Mammary Neoplasms 1 | 136
Arteriovenous malformation 1 | 8
Basal cell carcinoma 1 | 31
Capillary hemangioma 1 | 11
Cardiovascular system disease 1 | 194
Charcot-Marie-Tooth disease 1 | 74
Chemotherapy-induced nausea and vomiting 1 | 18
Cutis laxa 1 | 28
Dentin caries 1 | 4
Diabetic gastroparesis 1 | 7
Enamel caries 1 | 8
Frontotemporal dementia 1 | 47
Gastrointestinal Radiography Adjunct 1 | 11
HIV Infections 1 | 100
Heart conduction disease 1 | 65
Heart failure 1 | 80
Hereditary hemorrhagic telangiectasia 1 | 14
Heroin dependence 1 | 30
Hyperalgesia 1 | 71
Irritable bowel syndrome 1 | 59
Leukemia, Myelocytic, Acute 1 | 113
Long QT syndrome 1 | 53
Long QT syndrome 1 1 | 12
Lymphedema 1 | 26
Mammary Neoplasms, Experimental 1 | 150
Microcephaly 1 | 149
Myopathy 1 | 128
Narcolepsy 1 | 69
Poor school performance 1 | 13
Prevention of Post-Operative Nausea and Vomiting 1 | 14
Primary microcephaly 1 | 6
Renal Cell Carcinoma 1 | 199
Romano-Ward Syndrome 1 | 12
Seizure Adverse Event 1 | 19
Spina bifida occulta 1 | 7
Squamous cell carcinoma 1 | 96
Telangiectasis 1 | 20
cystic fibrosis and chronic rhinosinusitis 1 | 213
fascioscapulohumeral muscular dystrophy 1 | 100
interstitial lung disease 1 | 292

Tissue

Blood and immune system 20 | 17,995
Digestive Tract 20 | 18,473
Female tissues 20 | 18,647
Liver and Pancreas 20 | 18,136
Nervous System 20 | 18,561
Urinary Tract 20 | 18,444
Cardiovascular System 19 | 17,958
Endocrine System 19 | 18,512
Male tissues 19 | 17,969
Respiratory system 19 | 17,484
Skin and soft tissues 19 | 18,115

Target Family

Enzyme 7 | 4,146
Non-IDG 7 | 11,969
Transcription Factor 2 | 1,400
Epigenetic 1 | 242
GPCR 1 | 408
Ion Channel 1 | 341
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sequestosome-1 SQSTM1 Tbio Non-IDG -2.71345 536.6 655
Zinc finger protein 14 homolog ZFP14 Tdark Transcription Factor 0.30 0.13 60
DNA helicase INO80 INO80 Tbio Enzyme -2.54261 264.3 44
Basic leucine zipper and W2 domain-containing protein 2 BZW2 Tbio Non-IDG 0.07 0.41 76
DnaJ homolog subfamily B member 3 DNAJB3 Tdark Non-IDG 0.00000 0
DENN domain-containing protein 1B DENND1B Tbio Non-IDG -0.78972 6.46 116
Lysyl oxidase homolog 1 LOXL1 Tbio Enzyme -2.53721 344.5 145
GTPase IMAP family member 8 GIMAP8 Tbio Enzyme -0.98114 10.3 103
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein NOS1AP Tbio Enzyme -2.10900 133.4 142
Heat shock protein beta-1 HSPB1 Tchem Non-IDG -2.95716 939.2 1717