Development Level

Tbio 23 | 11,445
Tchem 4 | 1,598
Tdark 3 | 6,588
Tclin 2 | 613

IMPC Phenotype

increased body length 32 | 32
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 24 | 11,493
ovarian cancer 20 | 8,520
osteosarcoma 17 | 7,950
lung cancer 14 | 4,740
psoriasis 13 | 6,694
atypical teratoid / rhabdoid tumor 12 | 5,112
medulloblastoma, large-cell 12 | 6,241
group 3 medulloblastoma 10 | 4,104
lung adenocarcinoma 10 | 2,716
Breast cancer 9 | 3,578
ependymoma 9 | 4,679
glioblastoma 9 | 5,792
adult high grade glioma 8 | 3,801
malignant mesothelioma 8 | 3,232
non-small cell lung cancer 8 | 2,890
subependymal giant cell astrocytoma 8 | 2,287
Cancer 7 | 2,499
Kidney cancer 7 | 2,613
Pick disease 7 | 1,894
pancreatic cancer 7 | 2,398
astrocytic glioma 6 | 2,597
colon cancer 6 | 1,478
interstitial cystitis 6 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
invasive ductal carcinoma 6 | 2,951
Astrocytoma, Pilocytic 5 | 3,081
cystic fibrosis 5 | 1,696
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung carcinoma 5 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,109
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
Neurodegenerative disease 4 | 414
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
adrenocortical carcinoma 4 | 1,428
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
juvenile dermatomyositis 4 | 1,187
primitive neuroectodermal tumor 4 | 3,035
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Acquired metabolic disease 3 | 336
Cerebral atrophy 3 | 178
Decreased tendon reflex 3 | 122
Epilepsy 3 | 792
Hyperreflexia 3 | 209
Intellectual disability 3 | 1,016
Multiple myeloma 3 | 1,332
Muscle hypotonia 3 | 571
active Crohn's disease 3 | 922
aldosterone-producing adenoma 3 | 665
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
cutaneous lupus erythematosus 3 | 1,057
esophageal adenocarcinoma 3 | 737
medulloblastoma 3 | 720
oligodendroglioma 3 | 2,850
progressive supranuclear palsy 3 | 676
Adenocarcinoma of lung 2 | 142
Alzheimer's disease 2 | 658
Amyotrophic lateral sclerosis 2 | 451
Arthritis, Juvenile 2 | 126
Atrophy of cerebellum 2 | 103
Babinski Reflex 2 | 100
Carcinoma, Hepatocellular 2 | 228
Cerebellar degeneration 2 | 103
Coarse facial features 2 | 108
Duchenne muscular dystrophy 2 | 601
Dysarthria 2 | 192
Glaucoma 2 | 239
Hypothyroidism 2 | 122
Infratentorial atrophy 2 | 103
Juvenile arthritis 2 | 126
Liver Cirrhosis, Experimental 2 | 769
Liver carcinoma 2 | 240
Melanoma 2 | 711
Microcephaly 2 | 166
Multiple Sclerosis 2 | 540
Prostate cancer 2 | 175
Prostatic Neoplasms 2 | 495
Slow progression 2 | 89
Vascular disease 2 | 319
Waldenstrons macroglobulinemia 2 | 765
active ulcerative colitis 2 | 764
acute myeloid leukemia 2 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
hepatocellular carcinoma 2 | 547
nasopharyngeal carcinoma 2 | 1,058
pancreatic carcinoma 2 | 562
primary Sjogren syndrome 2 | 735
spina bifida 2 | 1,074
tuberculosis and treatment for 3 months 2 | 179
urothelial carcinoma 2 | 318

Tissue

Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Blood and immune system 31 | 16,909
Cardiovascular System 31 | 15,192
Female tissues 31 | 17,400
Nervous System 31 | 16,725
Urinary Tract 31 | 16,678

Target Family

Non-IDG 13 | 12,091
Enzyme 8 | 4,145
Kinase 3 | 634
Epigenetic 2 | 242
Transcription Factor 2 | 1,400
Transporter 2 | 473
Ion Channel 1 | 344
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein BEX4 BEX4 Tbio Non-IDG -0.42070 1.71 90
Potassium voltage-gated channel subfamily D member 3 KCND3 Tclin Ion Channel -2.34610 217.9 162
Biogenesis of lysosome-related organelles complex 1 subunit 2 BLOC1S2 Tbio Non-IDG -2.89123 759.6 79
Ethanolamine kinase 1 ETNK1 Tbio Kinase -1.59702 38.8 152
Lysyl oxidase homolog 1 LOXL1 Tbio Enzyme -2.55611 364.6 174
Heat shock protein beta-1 HSPB1 Tchem Non-IDG -2.97780 974.9 1992
Rho GTPase-activating protein 18 ARHGAP18 Tbio Enzyme -1.88387 75.8 122
Lysine-specific demethylase 2B KDM2B Tchem Epigenetic -1.56328 41.7 248
Metalloreductase STEAP2 STEAP2 Tbio Enzyme -1.78852 56.5 154
Fibroblast growth factor receptor 4 FGFR4 Tclin Kinase -2.44255 276.4 502