Development Level

Tbio 11 | 11,445
Tdark 5 | 6,588
Tchem 2 | 1,598
Tclin 1 | 613

IMPC Phenotype

increased anti-nuclear antigen... 19 | 19
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 11 | 11,493
osteosarcoma 9 | 7,950
medulloblastoma, large-cell 8 | 6,241
ovarian cancer 8 | 8,520
psoriasis 7 | 6,694
glioblastoma 6 | 5,792
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
Kidney cancer 4 | 2,613
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung cancer 4 | 4,740
Intellectual disability 3 | 1,016
Pick disease 3 | 1,894
adult high grade glioma 3 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung carcinoma 3 | 2,843
non-small cell lung cancer 3 | 2,890
pituitary cancer 3 | 1,972
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287
Acquired metabolic disease 2 | 336
Astrocytoma, Pilocytic 2 | 3,081
Breast cancer 2 | 3,578
Cancer 2 | 2,499
Down syndrome 2 | 499
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
gastric carcinoma 2 | 807
hepatocellular carcinoma 2 | 547
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primary Sjogren syndrome 2 | 735
tuberculosis 2 | 2,010
Abnormality of the fingernails 1 | 51
Abnormality of the hip bone 1 | 16
Absence of secondary sex characteristics 1 | 22
Addison's disease 1 | 31
Adrenocorticotropic hormone excess 1 | 5
Anovulation 1 | 21
Autoimmune polyendocrine syndrome 1 | 6
Bacterial vaginosis 1 | 15
Biotinidase deficiency 1 | 14
Blastic phase chronic myeloid leukemia 1 | 58
Borderline personality disorder 1 | 11
CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIl 1 | 1
Celiac disease 1 | 116
Chromosome 1q41-q42 deletion syndrome 1 | 4
Chronic Myelocytic Leukemia Accelerated Phase 1 | 59
Chronic lung disease 1 | 6
Chronic phase chronic myeloid leukemia 1 | 45
Congenital disorder of glycosylation type 2L 1 | 1
Convex nasal ridge 1 | 37
Decreased fertility 1 | 33
Dehydration 1 | 40
Delayed Puberty 1 | 97
Dentinogenesis imperfecta 1 | 25
Elevated follicle stimulating hormone 1 | 15
Elevated luteinizing hormone 1 | 14
Elevated plasma renin 1 | 9
Erythema 1 | 58
Female external genitalia in males 1 | 13
Flushing 1 | 60
Gestational choriocarcinoma 1 | 5
Griscelli syndrome 1 | 24
Gynecomastia 1 | 64
Hemophagocytic lymphohistiocytosis 1 | 30
Hyperkalemia 1 | 17
Hypotension 1 | 82
Infectious disease of lung 1 | 29
Iron metabolism disease 1 | 20
Leigh disease 1 | 100
Low maternal serum estriol 1 | 2
Lung adenoma 1 | 8
Multiple pulmonary infections 1 | 29
Organophosphate poisoning 1 | 4
Ovarian dysfunction 1 | 18
Papule 1 | 43
Petechiae 1 | 13
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 1 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 1 | 47
Photosensitive trichothiodystrophy 1 | 30
Photosensitivity of skin 1 | 51
Posterior amorphous corneal dystrophy 1 | 9
Premature ovarian failure 1 | 65
Recurrent pneumonia 1 | 29
Recurrent pulmonary infections 1 | 29
Renal salt wasting 1 | 18
Rotting teeth 1 | 73
SHAHEEN SYNDROME 1 | 1
Secondary malignant neoplasm of female breast 1 | 3
Sex reversal 1 | 10
Skin Ulcer 1 | 48
Small testicle 1 | 75
Stomach disease 1 | 8
Urogenital sinus anomaly 1 | 15
Wolman disease 1 | 6
cocaine use 1 | 11

Tissue

Endocrine System 19 | 18,159
Blood and immune system 18 | 16,909
Digestive Tract 17 | 17,369
Female tissues 17 | 17,400
Liver and Pancreas 17 | 16,750
Nervous System 17 | 16,725
Skin and soft tissues 17 | 17,230
Urinary Tract 17 | 16,678
Cardiovascular System 16 | 15,192
Male tissues 16 | 17,142
Respiratory system 15 | 16,393

Target Family

Non-IDG 10 | 12,091
Enzyme 7 | 4,145
Kinase 1 | 634
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cardiolipin synthase (CMP-forming) CRLS1 Tbio Enzyme -0.87118 6.24 100
Serine/threonine-protein kinase SIK3 SIK3 Tchem Kinase -1.18286 18.2 0
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -1.32757 20.2 148
Lymphoid-restricted membrane protein LRMP Tbio Non-IDG -1.19402 16.8 65
Uromodulin-like 1 UMODL1 Tdark Non-IDG -0.59014 4.62 22
Xaa-Pro dipeptidase PEPD Tchem Enzyme -2.97538 963.8 157
Placenta-expressed transcript 1 protein PLET1 Tbio Non-IDG -0.95863 9.75 52
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 PDZK1 Tbio Non-IDG -1.84451 68.6 301
Transmembrane and coiled-coil domain-containing protein 2 TMCO2 Tdark Non-IDG 0.00000 1.00 3
Probable E3 ubiquitin-protein ligase HERC1 HERC1 Tbio Enzyme -1.02371 5.75 39