Development Level

Tbio 19 | 11,445
Tchem 3 | 1,598
Tdark 3 | 6,588
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

impaired pupillary reflex 26 | 26
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 20 | 11,493
ovarian cancer 16 | 8,520
psoriasis 14 | 6,694
osteosarcoma 13 | 7,950
glioblastoma 11 | 5,792
medulloblastoma, large-cell 11 | 6,241
adult high grade glioma 8 | 3,801
atypical teratoid / rhabdoid tumor 8 | 5,112
lung cancer 8 | 4,740
primitive neuroectodermal tumor 8 | 3,035
ependymoma 7 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
oligodendroglioma 7 | 2,850
astrocytic glioma 6 | 2,597
group 3 medulloblastoma 6 | 4,104
group 4 medulloblastoma 6 | 1,855
Astrocytoma, Pilocytic 5 | 3,081
Breast cancer 5 | 3,578
Kidney cancer 5 | 2,613
Pick disease 5 | 1,894
Rheumatoid arthritis 5 | 1,191
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
lung adenocarcinoma 5 | 2,716
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
non primary Sjogren syndrome sicca 4 | 891
non-small cell lung cancer 4 | 2,890
Autosomal recessive predisposition 3 | 1,442
Craniosynostosis 3 | 74
Epilepsy 3 | 792
Liver cancer 3 | 604
colon cancer 3 | 1,478
pituitary cancer 3 | 1,972
Abnormality of retinal pigmentation 2 | 111
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Ankle clonus 2 | 6
Anteverted nostril 2 | 191
Atopic dermatitis 2 | 952
Bilateral fifth finger clinodactyly 2 | 110
Broad flat nasal bridge 2 | 236
Cancer 2 | 2,499
Cataract 2 | 297
Cleft Lip 2 | 141
Cleft Palate 2 | 271
Congenital hypoplasia of penis 2 | 176
Curvature of little finger 2 | 110
Curvature of spine 2 | 282
Difficulties with night vision 2 | 87
Down syndrome 2 | 499
Endometrial cancer 2 | 311
Intellectual disability 2 | 1,016
Lens Opacities 2 | 231
Liver Cirrhosis, Experimental 2 | 769
Lung disease 2 | 142
Matthew-Wood syndrome 2 | 11
Mental Depression 2 | 333
Multiple myeloma 2 | 1,332
Muscle hypotonia 2 | 571
Nasal bridge wide 2 | 236
Neurodegenerative disease 2 | 414
Night Blindness 2 | 101
Nystagmus 2 | 317
Optic Atrophy 2 | 242
Reduced visual acuity 2 | 63
Retinal Degeneration 2 | 106
Retinal pigment epithelial abnormality 2 | 111
Schizophrenia 2 | 1,160
Seizures 2 | 596
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
aldosterone-producing adenoma 2 | 665
breast carcinoma 2 | 1,638
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
ductal carcinoma in situ 2 | 1,745
facioscapulohumeral dystrophy 2 | 288
hereditary spastic paraplegia 2 | 318
interstitial cystitis 2 | 2,312
medulloblastoma 2 | 720
spina bifida 2 | 1,074
type II diabetes mellitus and post-ischemic heart failure 2 | 88
Adrenal Hyperplasia, Congenital 1 | 9
Arrhythmias, Cardiac 1 | 19
Chronic idiopathic constipation 1 | 3
Congenital hypoplasia of radius 1 | 23
Cortical visual impairment 1 | 24
Irritable bowel syndrome characterized by constipation 1 | 3
Nonepidermolytic palmoplantar keratoderma 1 | 12
Postnatal growth retardation 1 | 57
Postnatal microcephaly 1 | 24
Pylorospasm 1 | 1
Radial ray hypoplasia 1 | 23
Short ulnae 1 | 24
Treatment-resistant schizophrenia 1 | 6
ULNAR HYPOPLASIA 1 | 24
alcohol use disorder 1 | 12

Tissue

Digestive Tract 26 | 17,369
Endocrine System 26 | 18,159
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Nervous System 26 | 16,725
Skin and soft tissues 26 | 17,230
Blood and immune system 25 | 16,909
Male tissues 25 | 17,142
Respiratory system 25 | 16,393
Urinary Tract 23 | 16,678
Cardiovascular System 22 | 15,192

Target Family

Non-IDG 14 | 12,091
Enzyme 6 | 4,145
Epigenetic 3 | 242
GPCR 2 | 408
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
39S ribosomal protein L22, mitochondrial MRPL22 Tdark Non-IDG 0.70 0.21 64
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 ARAP3 Tbio Non-IDG -0.96067 13.8 85
5-hydroxytryptamine receptor 4 HTR4 Tclin GPCR -2.87235 796.4 248
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 Tbio Enzyme -1.13540 12.8 55
Unconventional myosin-X MYO10 Tbio Non-IDG -1.49855 36.4 47
Kinesin heavy chain isoform 5A KIF5A Tbio Non-IDG -1.69131 48.4 170
Ephrin-A4 EFNA4 Tbio Non-IDG -1.23647 17.4 213
Neurocalcin-delta NCALD Tbio Non-IDG -1.30940 20.7 102
Vesicular, overexpressed in cancer, prosurvival protein 1 VOPP1 Tbio Non-IDG -1.24852 17.6 85
Ras-related protein Rab-18 RAB18 Tbio Enzyme -1.62447 42.1 103