Development Level

Tbio 99 | 11,651
Tdark 14 | 6,593
Tchem 13 | 1,388
Tclin 6 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

hypoactivity 132 | 132
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 94 | 11,493
ovarian cancer 84 | 8,520
osteosarcoma 63 | 7,950
psoriasis 61 | 6,694
glioblastoma 58 | 5,792
atypical teratoid / rhabdoid tumor 55 | 5,112
medulloblastoma, large-cell 55 | 6,241
ependymoma 50 | 4,679
group 3 medulloblastoma 47 | 4,104
lung cancer 44 | 4,740
adult high grade glioma 42 | 3,801
Breast cancer 40 | 3,578
oligodendroglioma 33 | 2,850
primitive neuroectodermal tumor 33 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,291
Astrocytoma, Pilocytic 30 | 3,081
Kidney cancer 30 | 2,613
invasive ductal carcinoma 30 | 2,951
malignant mesothelioma 28 | 3,232
astrocytic glioma 27 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
Pick disease 25 | 1,894
subependymal giant cell astrocytoma 25 | 2,287
pancreatic cancer 23 | 2,398
Autosomal recessive predisposition 22 | 1,442
interstitial cystitis 22 | 2,312
lung adenocarcinoma 22 | 2,716
lung carcinoma 22 | 2,843
non-small cell lung cancer 22 | 2,890
breast carcinoma 21 | 1,638
ductal carcinoma in situ 20 | 1,745
pituitary cancer 20 | 1,972
Cancer 19 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
cystic fibrosis 18 | 1,696
diabetes mellitus 18 | 1,728
Intellectual disability 17 | 1,016
adrenocortical carcinoma 15 | 1,428
juvenile dermatomyositis 15 | 1,187
tuberculosis 14 | 2,010
Rheumatoid arthritis 13 | 1,191
Schizophrenia 13 | 1,160
group 4 medulloblastoma 13 | 1,855
acute quadriplegic myopathy 12 | 1,158
primary pancreatic ductal adenocarcinoma 12 | 1,109
ulcerative colitis 12 | 1,819
Atopic dermatitis 11 | 952
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Multiple myeloma 11 | 1,332
Obesity 11 | 678
Poor school performance 11 | 645
colon cancer 11 | 1,478
dermatomyositis 11 | 966
Down syndrome 10 | 499
cutaneous lupus erythematosus 10 | 1,057
Acquired metabolic disease 9 | 336
Epilepsy 9 | 792
Seizures 9 | 596
gastric carcinoma 9 | 807
spina bifida 9 | 1,074
Muscle hypotonia 8 | 571
Neurodegenerative disease 8 | 414
Waldenstrons macroglobulinemia 8 | 765
astrocytoma 8 | 1,146
fibroadenoma 8 | 559
pediatric high grade glioma 8 | 1,064
Amyotrophic lateral sclerosis 7 | 451
Bipolar Disorder 7 | 666
Breast Neoplasms 7 | 445
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
Nystagmus 7 | 317
Parkinson's disease 7 | 392
acute myeloid leukemia 7 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
medulloblastoma 7 | 720
non-small cell lung carcinoma 7 | 317
Alzheimer's disease 6 | 658
Gaucher disease type 1 6 | 180
Hepatomegaly 6 | 285
Hypertension 6 | 396
Hypogonadism 6 | 173
Liver Cirrhosis, Experimental 6 | 769
Mammary Neoplasms 6 | 425
Prostatic Neoplasms 6 | 495
Sensorineural Hearing Loss (disorder) 6 | 284
active ulcerative colitis 6 | 764
aldosterone-producing adenoma 6 | 665
esophageal adenocarcinoma 6 | 737
primary Sjogren syndrome 6 | 735
urothelial carcinoma 6 | 318
Duchenne muscular dystrophy 5 | 601
Glaucoma 5 | 239
Retinitis Pigmentosa 5 | 226
Short stature 5 | 531

Tissue

Endocrine System 129 | 18,159
Female tissues 126 | 17,400
Skin and soft tissues 126 | 17,230
Digestive Tract 125 | 17,369
Blood and immune system 123 | 16,909
Liver and Pancreas 123 | 16,750
Nervous System 123 | 16,725
Male tissues 122 | 17,142
Respiratory system 119 | 16,393
Urinary Tract 117 | 16,678
Cardiovascular System 114 | 15,192

Target Family

Non-IDG 71 | 12,091
Enzyme 40 | 4,145
Transcription Factor 9 | 1,400
Epigenetic 5 | 242
GPCR 2 | 408
TF/Epigenetic 2 | 38
Transporter 2 | 473
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66
Vacuolar protein sorting-associated protein 37D VPS37D Tdark Non-IDG 0.51 0.16 8
DNA helicase INO80 INO80 Tbio Enzyme -2.54124 327.2 47
Transcription initiation factor IIB GTF2B Tbio Non-IDG -2.63302 410.1 286
Endophilin-A1 SH3GL2 Tbio Non-IDG -1.79540 59.9 248
E3 ubiquitin-protein ligase NEDD4-like NEDD4L Tbio Enzyme -2.52486 353.9 144
F-box only protein 9 FBXO9 Tbio Non-IDG -0.42429 2.33 122
Leucyl-cystinyl aminopeptidase LNPEP Tchem Enzyme -2.57244 394.0 103
Protein FAM49B FAM49B Tdark Non-IDG -1.38473 22.2 47
Orexin HCRT Tbio Non-IDG -3.27696 2001.9 203