Development Level

Tbio 42 | 11,445
Tdark 13 | 6,588
Tclin 3 | 613
Tchem 2 | 1,598

Collection

RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

female infertility 60 | 60
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 39 | 11,493
ovarian cancer 33 | 8,520
osteosarcoma 26 | 7,950
glioblastoma 20 | 5,792
medulloblastoma, large-cell 20 | 6,241
psoriasis 20 | 6,694
ependymoma 18 | 4,679
atypical teratoid / rhabdoid tumor 17 | 5,112
group 3 medulloblastoma 14 | 4,104
lung cancer 14 | 4,740
primitive neuroectodermal tumor 14 | 3,035
malignant mesothelioma 13 | 3,232
adult high grade glioma 12 | 3,801
Cancer 11 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
invasive ductal carcinoma 11 | 2,951
Astrocytoma, Pilocytic 10 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
Breast cancer 9 | 3,578
colon cancer 9 | 1,478
lung adenocarcinoma 9 | 2,716
non-small cell lung cancer 9 | 2,890
astrocytic glioma 8 | 2,597
pancreatic cancer 8 | 2,398
pituitary cancer 8 | 1,972
ulcerative colitis 8 | 1,819
astrocytoma 7 | 1,146
group 4 medulloblastoma 7 | 1,855
oligodendroglioma 7 | 2,850
Kidney cancer 6 | 2,613
Rheumatoid arthritis 6 | 1,191
breast carcinoma 6 | 1,638
cutaneous lupus erythematosus 6 | 1,057
ductal carcinoma in situ 6 | 1,745
interstitial cystitis 6 | 2,312
lung carcinoma 6 | 2,843
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis 6 | 2,010
Atopic dermatitis 5 | 952
Infertility 5 | 188
Male infertility 5 | 206
Multiple myeloma 5 | 1,332
Pick disease 5 | 1,894
adrenocortical carcinoma 5 | 1,428
nasopharyngeal carcinoma 5 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
primary pancreatic ductal adenocarcinoma 5 | 1,109
Autosomal recessive predisposition 4 | 1,442
acute myeloid leukemia 4 | 783
medulloblastoma 4 | 720
spina bifida 4 | 1,074
Asthma 3 | 385
Down syndrome 3 | 499
Waldenstrons macroglobulinemia 3 | 765
active Crohn's disease 3 | 922
dermatomyositis 3 | 966
fibroadenoma 3 | 559
gastric cancer 3 | 459
gastric carcinoma 3 | 807
hepatocellular carcinoma 3 | 547
hereditary spastic paraplegia 3 | 318
non primary Sjogren syndrome sicca 3 | 891
posterior fossa group B ependymoma 3 | 416
primary Sjogren syndrome 3 | 735
Azoospermia 2 | 110
Big calvaria 2 | 147
Bipolar Disorder 2 | 666
Carcinoma, Hepatocellular 2 | 228
Cholestasis 2 | 155
Gaucher disease type 1 2 | 180
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Liver cancer 2 | 604
Liver carcinoma 2 | 240
Melanocytic nevus 2 | 43
Melanoma 2 | 711
Microcephaly 2 | 166
Muscle hypotonia 2 | 571
Neutropenia 2 | 72
Nevus 2 | 19
Premature Menopause 2 | 31
Premature ovarian failure 2 | 65
Relapsing remitting multiple sclerosis 2 | 14
Schizophrenia 2 | 1,160
Sertoli cell-only syndrome 2 | 37
Stomach Neoplasms 2 | 300
Thrombocytopenia 2 | 197
Triangular face 2 | 58
atypical teratoid/rhabdoid tumor 2 | 357
chronic rhinosinusitis 2 | 512
inflammatory breast cancer 2 | 286
juvenile dermatomyositis 2 | 1,187
mucosa-associated lymphoid tissue lymphoma 2 | 484
nephrosclerosis 2 | 333
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
posterior fossa group A ependymoma 2 | 468
progressive supranuclear palsy 2 | 676

Tissue

Endocrine System 57 | 18,159
Male tissues 56 | 17,142
Digestive Tract 55 | 17,369
Blood and immune system 54 | 16,909
Skin and soft tissues 53 | 17,230
Female tissues 52 | 17,400
Nervous System 52 | 16,725
Liver and Pancreas 51 | 16,750
Respiratory system 50 | 16,393
Urinary Tract 50 | 16,678
Cardiovascular System 49 | 15,192

Target Family

Non-IDG 31 | 12,091
Enzyme 13 | 4,145
Transcription Factor 6 | 1,400
Epigenetic 4 | 242
GPCR 3 | 408
Ion Channel 1 | 344
Kinase 1 | 634
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methyl-CpG-binding domain protein 1 MBD1 Tbio Transcription Factor -2.23809 171.1 297
Transmembrane protein 248 TMEM248 Tdark Non-IDG 0.00000 47
Embryonic polyadenylate-binding protein 2 PABPN1L Tdark Non-IDG -0.16137 1.83 53
E3 ubiquitin-protein ligase UHRF2 UHRF2 Tbio Epigenetic -1.57250 40.4 202
Cohesin subunit SA-3 STAG3 Tbio Non-IDG -1.30055 20.0 104
Ubiquitin carboxyl-terminal hydrolase 15 USP15 Tbio Enzyme -1.64742 41.6 242
Spermatogenesis-associated protein 16 SPATA16 Tbio Non-IDG -0.85496 7.02 48
Sperm-egg fusion protein Juno IZUMO1R Tbio Non-IDG -1.78804 57.0 212
E3 ubiquitin-protein ligase TRIM37 TRIM37 Tbio Enzyme -3.25892 1754.8 177
Glutamine-dependent NAD(+) synthetase NADSYN1 Tbio Enzyme -1.21917 15.2 60