Development Level

Tbio 19 | 11,445
Tdark 9 | 6,588
Tchem 8 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

enlarged lymph nodes 37 | 37
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 28 | 11,493
ovarian cancer 21 | 8,520
lung cancer 17 | 4,740
osteosarcoma 17 | 7,950
glioblastoma 16 | 5,792
atypical teratoid / rhabdoid tumor 15 | 5,112
medulloblastoma, large-cell 15 | 6,241
astrocytic glioma 12 | 2,597
psoriasis 12 | 6,694
Astrocytoma, Pilocytic 11 | 3,081
Autosomal recessive predisposition 11 | 1,442
ependymoma 11 | 4,679
group 3 medulloblastoma 11 | 4,104
malignant mesothelioma 11 | 3,232
primitive neuroectodermal tumor 11 | 3,035
adult high grade glioma 10 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
lung adenocarcinoma 10 | 2,716
Breast cancer 9 | 3,578
invasive ductal carcinoma 9 | 2,951
Cancer 8 | 2,499
oligodendroglioma 8 | 2,850
acute quadriplegic myopathy 7 | 1,158
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Intellectual disability 6 | 1,016
Kidney cancer 6 | 2,613
Mental and motor retardation 6 | 608
ductal carcinoma in situ 6 | 1,745
group 4 medulloblastoma 6 | 1,855
interstitial cystitis 6 | 2,312
juvenile dermatomyositis 6 | 1,187
Epilepsy 5 | 792
Short stature 5 | 531
active ulcerative colitis 5 | 764
breast carcinoma 5 | 1,638
esophageal adenocarcinoma 5 | 737
lung carcinoma 5 | 2,843
pancreatic cancer 5 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
progressive supranuclear palsy 5 | 676
subependymal giant cell astrocytoma 5 | 2,287
Broad flat nasal bridge 4 | 236
Cleft Lip 4 | 141
Cleft Palate 4 | 271
Dull intelligence 4 | 645
Failure to gain weight 4 | 365
Hepatomegaly 4 | 285
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple Sclerosis 4 | 540
Multiple myeloma 4 | 1,332
Muscle hypotonia 4 | 571
Nasal bridge wide 4 | 236
Nystagmus 4 | 317
Pediatric failure to thrive 4 | 365
Poor school performance 4 | 645
Retinitis Pigmentosa 4 | 226
Seizures 4 | 596
Small head 4 | 374
colon cancer 4 | 1,478
cystic fibrosis 4 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
nasopharyngeal carcinoma 4 | 1,058
non-small cell lung cancer 4 | 2,890
pediatric high grade glioma 4 | 1,064
tuberculosis 4 | 2,010
Atopic dermatitis 3 | 952
Atrophy of cerebellum 3 | 103
Cerebellar degeneration 3 | 103
Cerebral atrophy 3 | 178
Delayed Puberty 3 | 97
Diarrhea 3 | 253
Downward slant of palpebral fissure 3 | 158
Generalized osteopenia 3 | 99
Highly variable clinical phenotype 3 | 150
Highly variable phenotype and severity 3 | 150
Highly variable phenotype, even within families 3 | 150
Hydrocephalus 3 | 152
Infratentorial atrophy 3 | 103
Kidney Failure 3 | 111
Liver Cirrhosis, Experimental 3 | 769
Long face 3 | 71
Osteopenia 3 | 99
Phenotypic variability 3 | 150
Pick disease 3 | 1,894
Proteinuria 3 | 144
Skin tag 3 | 14
Splenomegaly 3 | 190
Tooth agenesis 3 | 44
Uranostaphyloschisis 3 | 167
astrocytoma 3 | 1,146
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
non primary Sjogren syndrome sicca 3 | 891
primary Sjogren syndrome 3 | 735
spina bifida 3 | 1,074
hereditary spastic paraplegia 2 | 318

Tissue

Digestive Tract 35 | 17,369
Endocrine System 35 | 18,159
Male tissues 35 | 17,142
Skin and soft tissues 35 | 17,230
Blood and immune system 34 | 16,909
Female tissues 34 | 17,400
Liver and Pancreas 34 | 16,750
Respiratory system 34 | 16,393
Urinary Tract 34 | 16,678
Cardiovascular System 33 | 15,192
Nervous System 33 | 16,725

Target Family

Non-IDG 20 | 12,091
Enzyme 8 | 4,145
Kinase 4 | 634
Transcription Factor 2 | 1,400
Epigenetic 1 | 242
Ion Channel 1 | 344
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylmalonic aciduria and homocystinuria type C protein MMACHC Tbio Non-IDG -1.83573 76.5 233
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit DDOST Tchem Enzyme -1.60313 44.1 140
Cat eye syndrome critical region protein 2 CECR2 Tchem Epigenetic -2.17030 147.0 44
SKI/DACH domain-containing protein 1 SKIDA1 Tdark Non-IDG -0.23045 1.67 0
GTP-binding protein 2 GTPBP2 Tbio Non-IDG -0.72990 5.05 143
Leucine-rich repeat-containing protein 30 LRRC30 Tdark Non-IDG 0.00000 5
DNA-directed RNA polymerase III subunit RPC1 POLR3A Tbio Enzyme -2.25632 178.2 99
Transforming growth factor beta-3 TGFB3 Tbio Non-IDG -3.02749 1062.5 308
AMP deaminase 1 AMPD1 Tchem Enzyme -2.35602 227.5 148
Phosphomannomutase 2 PMM2 Tchem Enzyme -2.12990 128.2 153