Development Level

Tbio 176 | 11,445
Tchem 33 | 1,598
Tdark 22 | 6,588
Tclin 8 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

embryonic lethality prior to o... 239 | 239
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

ovarian cancer 158 | 8,520
Carcinoma 145 | 11,493
osteosarcoma 125 | 7,950
medulloblastoma, large-cell 81 | 6,241
psoriasis 76 | 6,694
lung cancer 73 | 4,740
glioblastoma 71 | 5,792
atypical teratoid / rhabdoid tumor 68 | 5,112
group 3 medulloblastoma 64 | 4,104
Breast cancer 55 | 3,578
malignant mesothelioma 47 | 3,232
Autosomal recessive predisposition 45 | 1,442
Cancer 45 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,291
primitive neuroectodermal tumor 43 | 3,035
ependymoma 42 | 4,679
Kidney cancer 41 | 2,613
Multiple myeloma 38 | 1,332
non-small cell lung cancer 36 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,955
lung adenocarcinoma 33 | 2,716
adult high grade glioma 32 | 3,801
Pick disease 31 | 1,894
astrocytic glioma 31 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,989
oligodendroglioma 31 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,962
invasive ductal carcinoma 30 | 2,951
diabetes mellitus 29 | 1,728
breast carcinoma 27 | 1,638
tuberculosis 27 | 2,010
pancreatic cancer 25 | 2,398
Cognitive delay 24 | 608
Global developmental delay 24 | 608
Mental and motor retardation 24 | 608
Intellectual disability 23 | 1,016
Waldenstrons macroglobulinemia 23 | 765
astrocytoma 23 | 1,146
Epilepsy 21 | 792
acute quadriplegic myopathy 21 | 1,158
adrenocortical carcinoma 21 | 1,428
dermatomyositis 21 | 966
group 4 medulloblastoma 20 | 1,855
ulcerative colitis 20 | 1,819
Astrocytoma, Pilocytic 19 | 3,081
Seizures 19 | 596
colon cancer 19 | 1,478
pituitary cancer 19 | 1,972
Muscle hypotonia 18 | 571
Schizophrenia 18 | 1,160
Failure to gain weight 17 | 365
Pediatric failure to thrive 17 | 365
acute myeloid leukemia 17 | 783
ductal carcinoma in situ 17 | 1,745
interstitial cystitis 17 | 2,312
Cerebellar Ataxia 16 | 304
Dull intelligence 16 | 645
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Poor school performance 16 | 645
non primary Sjogren syndrome sicca 16 | 891
subependymal giant cell astrocytoma 16 | 2,287
Neurodegenerative disease 15 | 414
Rheumatoid arthritis 15 | 1,191
pediatric high grade glioma 15 | 1,064
hepatocellular carcinoma 14 | 547
juvenile dermatomyositis 14 | 1,187
Breast Neoplasms 13 | 445
Nystagmus 13 | 317
Short stature 13 | 531
spina bifida 13 | 1,074
Endometriosis 12 | 540
Mammary Neoplasms 12 | 425
Strabismus 12 | 270
nasopharyngeal carcinoma 12 | 1,058
Dysarthria 11 | 192
Muscle Spasticity 11 | 195
Small head 11 | 374
cutaneous lupus erythematosus 11 | 1,057
lung carcinoma 11 | 2,843
Alzheimer's disease 10 | 658
Cerebral atrophy 10 | 178
Congenital disorder of glycosylation 10 | 54
Hepatomegaly 10 | 285
Optic Atrophy 10 | 242
Sensorineural Hearing Loss (disorder) 10 | 284
medulloblastoma 10 | 720
primary pancreatic ductal adenocarcinoma 10 | 1,109
Atrophy of cerebellum 9 | 103
Bipolar Disorder 9 | 666
Cerebellar degeneration 9 | 103
Cerebrovascular disease 9 | 238
Cryptorchidism 9 | 296
Hyperreflexia 9 | 209
Hypoplastic mandible condyle 9 | 275
Infratentorial atrophy 9 | 103
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
esophageal adenocarcinoma 9 | 737

Tissue

Endocrine System 238 | 18,159
Blood and immune system 237 | 16,909
Digestive Tract 237 | 17,369
Female tissues 237 | 17,400
Liver and Pancreas 237 | 16,750
Male tissues 237 | 17,142
Nervous System 237 | 16,725
Respiratory system 237 | 16,393
Skin and soft tissues 237 | 17,230
Urinary Tract 237 | 16,678
Cardiovascular System 235 | 15,192

Target Family

Non-IDG 108 | 12,091
Enzyme 100 | 4,145
Kinase 16 | 634
Transporter 5 | 473
Epigenetic 4 | 242
Transcription Factor 4 | 1,400
GPCR 2 | 408

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.13403 13.5 180
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit DDOST Tchem Enzyme -1.60313 44.1 140
Dolichol kinase DOLK Tbio Enzyme -1.89047 77.2 58
Pre-mRNA-splicing factor RBM22 RBM22 Tbio Non-IDG -0.84549 7.65 130
Pre-mRNA-splicing factor CWC22 homolog CWC22 Tbio Non-IDG -3.08456 1172.8 103
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
Spindle and kinetochore-associated protein 2 SKA2 Tbio Non-IDG -1.23206 10.2 108
Protein SGT1 homolog SUGT1 Tbio Non-IDG -0.79781 9.93 183
Translation initiation factor eIF-2B subunit delta EIF2B4 Tbio Non-IDG -1.06082 11.3 145
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC Tbio Enzyme -2.73791 419.9 129