Development Level

Tbio 44 | 11,445
Tchem 7 | 1,598
Tclin 4 | 613
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

edema 59 | 59
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 38 | 11,493
ovarian cancer 34 | 8,520
osteosarcoma 32 | 7,950
medulloblastoma, large-cell 22 | 6,241
psoriasis 21 | 6,694
glioblastoma 20 | 5,792
atypical teratoid / rhabdoid tumor 18 | 5,112
ependymoma 18 | 4,679
oligodendroglioma 18 | 2,850
lung cancer 17 | 4,740
astrocytic glioma 16 | 2,597
Breast cancer 14 | 3,578
group 3 medulloblastoma 14 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
non-small cell lung cancer 13 | 2,890
lung adenocarcinoma 12 | 2,716
primitive neuroectodermal tumor 12 | 3,035
Cancer 11 | 2,499
adult high grade glioma 11 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
adrenocortical carcinoma 10 | 1,428
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
invasive ductal carcinoma 10 | 2,951
pituitary cancer 10 | 1,972
acute quadriplegic myopathy 9 | 1,158
breast carcinoma 9 | 1,638
malignant mesothelioma 9 | 3,232
Astrocytoma, Pilocytic 8 | 3,081
Kidney cancer 8 | 2,613
Pick disease 8 | 1,894
ductal carcinoma in situ 8 | 1,745
group 4 medulloblastoma 8 | 1,855
lung carcinoma 8 | 2,843
pancreatic cancer 8 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
ulcerative colitis 8 | 1,819
colon cancer 7 | 1,478
primary pancreatic ductal adenocarcinoma 7 | 1,109
subependymal giant cell astrocytoma 7 | 2,287
Autosomal recessive predisposition 6 | 1,442
dermatomyositis 6 | 966
gastric carcinoma 6 | 807
juvenile dermatomyositis 6 | 1,187
medulloblastoma 6 | 720
Atopic dermatitis 5 | 952
Epilepsy 5 | 792
Liver Cirrhosis, Experimental 5 | 769
Multiple myeloma 5 | 1,332
Rheumatoid arthritis 5 | 1,191
Seizures 5 | 596
acute myeloid leukemia 5 | 783
astrocytoma 5 | 1,146
interstitial cystitis 5 | 2,312
primary Sjogren syndrome 5 | 735
tuberculosis 5 | 2,010
Amyotrophic lateral sclerosis 4 | 451
Bipolar Disorder 4 | 666
Melanoma 4 | 711
Parkinson's disease 4 | 392
Schizophrenia 4 | 1,160
aldosterone-producing adenoma 4 | 665
cystic fibrosis 4 | 1,696
nasopharyngeal carcinoma 4 | 1,058
pancreatic carcinoma 4 | 562
pediatric high grade glioma 4 | 1,064
Alzheimer's disease 3 | 658
Attention deficit hyperactivity disorder 3 | 278
Cardiomyopathy 3 | 116
Cleft Palate 3 | 271
Down syndrome 3 | 499
Hypertension 3 | 396
Hypertensive disease 3 | 292
Intellectual disability 3 | 1,016
Liver cancer 3 | 604
Obesity 3 | 678
chronic rhinosinusitis 3 | 512
cutaneous lupus erythematosus 3 | 1,057
posterior fossa group B ependymoma 3 | 416
tuberculosis and treatment for 3 months 3 | 179
Cardiomyopathy, Dilated 2 | 83
Cerebrovascular disease 2 | 238
Coronary artery disease 2 | 268
Depressive disorder 2 | 409
Essential Hypertension 2 | 94
Heart disease 2 | 306
Hepatomegaly 2 | 285
Major Depressive Disorder 2 | 301
Mental Depression 2 | 333
Micromelia 2 | 58
Neurodegenerative disease 2 | 414
Skin cancer 2 | 469
Toxic encephalopathy 2 | 141
Unipolar Depression 2 | 250
active ulcerative colitis 2 | 764
atypical teratoid/rhabdoid tumor 2 | 357
esophageal adenocarcinoma 2 | 737
fibroadenoma 2 | 559
head and neck cancer 2 | 271
hepatocellular carcinoma 2 | 547
spina bifida 2 | 1,074

Tissue

Endocrine System 58 | 18,159
Male tissues 58 | 17,142
Nervous System 58 | 16,725
Blood and immune system 57 | 16,909
Digestive Tract 57 | 17,369
Female tissues 57 | 17,400
Respiratory system 57 | 16,393
Skin and soft tissues 57 | 17,230
Urinary Tract 57 | 16,678
Liver and Pancreas 56 | 16,750
Cardiovascular System 55 | 15,192

Target Family

Non-IDG 35 | 12,091
Enzyme 12 | 4,145
Epigenetic 4 | 242
Kinase 3 | 634
Transporter 2 | 473
GPCR 1 | 408
Ion Channel 1 | 344
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
E3 ubiquitin-protein ligase UHRF2 UHRF2 Tbio Epigenetic -1.57250 40.4 202
Lysosomal-associated transmembrane protein 4B LAPTM4B Tbio Non-IDG -1.90763 86.1 91
Transmembrane protein 100 TMEM100 Tbio Non-IDG -0.92226 8.79 100
Biogenesis of lysosome-related organelles complex 1 subunit 2 BLOC1S2 Tbio Non-IDG -2.89123 759.6 79
Transmembrane protein 115 TMEM115 Tbio Non-IDG -1.77886 56.2 83
Volume-regulated anion channel subunit LRRC8A LRRC8A Tbio Non-IDG -1.55179 39.4 129
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
RNA-binding protein EWS EWSR1 Tbio Non-IDG -3.04399 1141.6 411
Methylmalonic aciduria and homocystinuria type C protein MMACHC Tbio Non-IDG -1.83573 76.5 233