Development Level

Tbio 149 | 11,651
Tdark 24 | 6,593
Tchem 22 | 1,388
Tclin 13 | 612

Collection

RFA-RM-18-021 6 | 328
GPCR: IDG Consortium (Targets) 2 | 126
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

decreased vertical activity 208 | 208
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 114 | 11,493
ovarian cancer 101 | 8,520
osteosarcoma 88 | 7,950
psoriasis 86 | 6,694
medulloblastoma, large-cell 81 | 6,241
glioblastoma 69 | 5,792
atypical teratoid / rhabdoid tumor 59 | 5,112
lung cancer 59 | 4,740
group 3 medulloblastoma 53 | 4,104
ependymoma 51 | 4,679
adult high grade glioma 48 | 3,801
lung carcinoma 48 | 2,843
non-small cell lung cancer 46 | 2,890
Breast cancer 45 | 3,578
lung adenocarcinoma 44 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,955
Cancer 41 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,291
oligodendroglioma 41 | 2,850
invasive ductal carcinoma 39 | 2,951
Astrocytoma, Pilocytic 36 | 3,081
malignant mesothelioma 36 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
interstitial cystitis 33 | 2,312
primitive neuroectodermal tumor 33 | 3,035
astrocytic glioma 31 | 2,597
breast carcinoma 29 | 1,638
pancreatic cancer 29 | 2,398
pituitary cancer 28 | 1,972
diabetes mellitus 25 | 1,728
ductal carcinoma in situ 25 | 1,745
cystic fibrosis 24 | 1,696
subependymal giant cell astrocytoma 24 | 2,287
tuberculosis 24 | 2,010
colon cancer 23 | 1,478
Kidney cancer 22 | 2,613
adrenocortical carcinoma 22 | 1,428
ulcerative colitis 21 | 1,819
Autosomal recessive predisposition 20 | 1,442
Atopic dermatitis 19 | 952
Pick disease 19 | 1,894
Obesity 18 | 678
cutaneous lupus erythematosus 17 | 1,057
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
Multiple myeloma 16 | 1,332
Schizophrenia 16 | 1,160
group 4 medulloblastoma 16 | 1,855
spina bifida 16 | 1,074
Rheumatoid arthritis 15 | 1,191
pediatric high grade glioma 15 | 1,064
primary pancreatic ductal adenocarcinoma 15 | 1,109
Alzheimer's disease 13 | 658
Epilepsy 13 | 792
active ulcerative colitis 13 | 764
fibroadenoma 13 | 559
Breast Neoplasms 12 | 445
Cerebrovascular disease 12 | 238
Mammary Neoplasms 12 | 425
Multiple Sclerosis 12 | 540
acute quadriplegic myopathy 12 | 1,158
astrocytoma 12 | 1,146
gastric carcinoma 12 | 807
medulloblastoma 12 | 720
Depressive disorder 11 | 409
active Crohn's disease 11 | 922
dermatomyositis 11 | 966
non primary Sjogren syndrome sicca 11 | 891
Bipolar Disorder 10 | 666
Liver Cirrhosis, Experimental 10 | 769
Prostatic Neoplasms 10 | 495
aldosterone-producing adenoma 10 | 665
juvenile dermatomyositis 10 | 1,187
Kidney disease 9 | 430
Seizures 9 | 596
posterior fossa group A ependymoma 9 | 468
Acquired metabolic disease 8 | 336
Asthma 8 | 385
Intellectual disability 8 | 1,016
Melanoma 8 | 711
Muscle hypotonia 8 | 571
chronic rhinosinusitis 8 | 512
mucosa-associated lymphoid tissue lymphoma 8 | 484
nasopharyngeal carcinoma 8 | 1,058
Atherosclerosis 7 | 291
Endometriosis 7 | 540
Heart disease 7 | 306
Mammary Neoplasms, Experimental 7 | 154
Mental Depression 7 | 333
Neurodegenerative disease 7 | 414
Polycystic ovary syndrome 7 | 360
Retinitis Pigmentosa 7 | 226
Short stature 7 | 531
chronic lymphosyte leukemia 7 | 204
hepatocellular carcinoma 7 | 547
pancreatic carcinoma 7 | 562
primary Sjogren syndrome 7 | 735
Attention deficit hyperactivity disorder 6 | 278
Crohn's disease 6 | 321
Duchenne muscular dystrophy 6 | 601
esophageal adenocarcinoma 6 | 737

Tissue

Endocrine System 196 | 18,159
Male tissues 193 | 17,142
Digestive Tract 191 | 17,369
Female tissues 191 | 17,400
Skin and soft tissues 189 | 17,230
Nervous System 187 | 16,725
Liver and Pancreas 186 | 16,750
Urinary Tract 186 | 16,678
Blood and immune system 180 | 16,909
Respiratory system 179 | 16,393
Cardiovascular System 163 | 15,192

Target Family

Non-IDG 114 | 12,091
Enzyme 40 | 4,145
Transcription Factor 17 | 1,400
GPCR 16 | 408
Kinase 8 | 634
Ion Channel 7 | 344
Epigenetic 2 | 242
Nuclear Receptor 2 | 48
Transporter 2 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
Sorting nexin-22 SNX22 Tdark Non-IDG -0.21085 1.62 25
Ephrin type-A receptor 6 EPHA6 Tchem Kinase -1.34848 21.8 266
Insulin-like peptide INSL5 INSL5 Tbio Non-IDG -1.42311 26.9 46
Leucine-rich repeat-containing protein 10 LRRC10 Tdark Non-IDG -0.93112 8.19 42
EF-hand calcium-binding domain-containing protein 4B CRACR2A Tchem Non-IDG -0.52797 3.72 130
Endophilin-A1 SH3GL2 Tbio Non-IDG -1.79540 59.9 248
Transcription factor AP-4 TFAP4 Tbio Transcription Factor -1.33384 19.4 276
Epidermal growth factor-like protein 8 EGFL8 Tdark Non-IDG -1.65003 39.7 50
G-protein-signaling modulator 3 GPSM3 Tbio Non-IDG -1.97857 92.6 35