Development Level

Tbio 11 | 11,651
Tchem 2 | 1,388
Tclin 2 | 612
Tdark 2 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

decreased total retina thickne... 17 | 17
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

ovarian cancer 13 | 8,520
Carcinoma 8 | 11,493
medulloblastoma, large-cell 7 | 6,241
osteosarcoma 6 | 7,950
psoriasis 6 | 6,694
lung cancer 5 | 4,740
glioblastoma 4 | 5,792
group 4 medulloblastoma 4 | 1,855
lung adenocarcinoma 4 | 2,716
spina bifida 4 | 1,074
Breast cancer 3 | 3,578
Cancer 3 | 2,499
Intellectual disability 3 | 1,016
Kidney cancer 3 | 2,613
adult high grade glioma 3 | 3,801
atypical teratoid / rhabdoid tumor 3 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
malignant mesothelioma 3 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Chronic obstructive pulmonary disease 2 | 184
Colorectal Neoplasms 2 | 243
Kidney Diseases 2 | 114
Multiple myeloma 2 | 1,332
Rheumatoid arthritis 2 | 1,191
Waldenstrons macroglobulinemia 2 | 765
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
dermatomyositis 2 | 966
ependymoma 2 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
lung carcinoma 2 | 2,843
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819
Adenoid Cystic Carcinoma 1 | 99
Alopecia 1 | 115
Alzheimer's disease 1 | 658
Amyotrophic lateral sclerosis type 3 1 | 17
Anemia 1 | 365
Arts syndrome 1 | 26
Atherosclerosis 1 | 291
Atopic dermatitis 1 | 952
Brain Injuries 1 | 65
Brain Ischemia 1 | 110
Breast Neoplasms 1 | 445
Carcinoma in situ of fallopian tube 1 | 4
Carcinoma, Adenoid Cystic 1 | 99
Cardiomyopathies 1 | 110
Cerebrovascular disease 1 | 238
Cholera 1 | 34
Chromosome 15q24 deletion syndrome 1 | 12
Craniofacial Abnormalities 1 | 151
Delayed speech and language development 1 | 112
Dementia 1 | 175
Dermatitis 1 | 157
Diabetes mellitus type 2 1 | 69
Diphtheria 1 | 40
Epithelial tumor of ovary 1 | 3
Gilles de la Tourette syndrome 1 | 47
Gross motor development delay 1 | 21
Hermansky-Pudlak syndrome 1 | 42
Hypersplenism 1 | 10
Inflammation 1 | 120
Kleefstra syndrome 1 | 12
Koolen de Vries syndrome 1 | 18
Language Delay 1 | 112
Leigh disease 1 | 100
Listeriosis 1 | 18
Liver Cirrhosis, Experimental 1 | 769
Liver cancer 1 | 604
Malignant epithelial tumor of ovary 1 | 5
Malignant tumor of ovary 1 | 25
Malignant tumor of peritoneum 1 | 6
Mammary Neoplasms 1 | 425
Melanoma 1 | 711
Mesothelioma, Malignant 1 | 105
Mitral valve insufficiency 1 | 49
Neoplasm Metastasis 1 | 168
Neurodegenerative disease 1 | 414
Palmoplantar keratosis 1 | 74
Parkinson's disease 1 | 392
Parkinsonian Disorders 1 | 56
Pertussis 1 | 20
Pitt-Hopkins syndrome 1 | 20
Pneumonia 1 | 174
Pulmonary Fibrosis 1 | 106
Speech Delay 1 | 112
Speech impairment 1 | 112
Stevens-Johnson syndrome 1 | 92
Toxic encephalopathy 1 | 141
Treatment Refractory Type 2 Diabetes Mellitus 1 | 53
Williams-Beuren syndrome 1 | 50
cystic fibrosis 1 | 1,696
fascioscapulohumeral muscular dystrophy 1 | 100
fibroadenoma 1 | 559
hepatocellular carcinoma 1 | 547
inflammatory breast cancer 1 | 286
pediatric high grade glioma 1 | 1,064

Tissue

Blood and immune system 17 | 16,909
Cardiovascular System 17 | 15,192
Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Female tissues 17 | 17,400
Liver and Pancreas 17 | 16,750
Male tissues 17 | 17,142
Nervous System 17 | 16,725
Respiratory system 17 | 16,393
Skin and soft tissues 17 | 17,230
Urinary Tract 17 | 16,678

Target Family

Non-IDG 9 | 12,091
Enzyme 6 | 4,145
GPCR 1 | 408
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase FTSJ1 Tbio Enzyme -1.64419 45.9 108
Vacuolar protein sorting-associated protein 37D VPS37D Tdark Non-IDG 0.51 0.16 8
Atypical chemokine receptor 3 ACKR3 Tchem GPCR -1.91187 99.0 476
WD repeat and SOCS box-containing protein 2 WSB2 Tbio Non-IDG -1.13752 13.3 68
KAT8 regulatory NSL complex subunit 1 KANSL1 Tbio Non-IDG -1.27149 17.9 36
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 Tclin Enzyme -0.99819 10.3 149
R-spondin-1 RSPO1 Tbio Non-IDG -2.26774 188.7 164
Poly [ADP-ribose] polymerase 1 PARP1 Tclin Enzyme -3.72278 4886.5 1453
Bromo adjacent homology domain-containing 1 protein BAHD1 Tbio Non-IDG -0.70852 6.49 66
E3 ubiquitin-protein ligase RNF144B RNF144B Tbio Enzyme -1.43635 26.6 245