Development Level

Tbio 138 | 11,445
Tdark 32 | 6,588
Tchem 29 | 1,598
Tclin 8 | 613

Collection

RFA-RM-18-021 3 | 328
GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

decreased total body fat amoun... 207 | 207
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 143 | 11,493
ovarian cancer 123 | 8,520
osteosarcoma 121 | 7,950
medulloblastoma, large-cell 105 | 6,241
psoriasis 103 | 6,694
glioblastoma 101 | 5,792
atypical teratoid / rhabdoid tumor 90 | 5,112
ependymoma 80 | 4,679
lung cancer 76 | 4,740
group 3 medulloblastoma 66 | 4,104
malignant mesothelioma 57 | 3,232
Astrocytoma, Pilocytic 55 | 3,081
adult high grade glioma 54 | 3,801
primitive neuroectodermal tumor 53 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 48 | 3,291
oligodendroglioma 48 | 2,850
invasive ductal carcinoma 47 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,955
Kidney cancer 45 | 2,613
Pick disease 45 | 1,894
astrocytic glioma 44 | 2,597
Breast cancer 43 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,989
subependymal giant cell astrocytoma 41 | 2,287
lung carcinoma 40 | 2,843
non-small cell lung cancer 39 | 2,890
lung adenocarcinoma 38 | 2,716
pancreatic cancer 38 | 2,398
pituitary cancer 36 | 1,972
group 4 medulloblastoma 34 | 1,855
Cancer 31 | 2,499
interstitial cystitis 31 | 2,312
astrocytoma 30 | 1,146
ductal carcinoma in situ 29 | 1,745
Schizophrenia 27 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
pediatric high grade glioma 26 | 1,064
Autosomal recessive predisposition 24 | 1,442
ulcerative colitis 24 | 1,819
spina bifida 23 | 1,074
Bipolar Disorder 21 | 666
Rheumatoid arthritis 21 | 1,191
acute quadriplegic myopathy 21 | 1,158
breast carcinoma 21 | 1,638
colon cancer 21 | 1,478
juvenile dermatomyositis 20 | 1,187
Atopic dermatitis 19 | 952
tuberculosis 19 | 2,010
progressive supranuclear palsy 18 | 676
Multiple myeloma 17 | 1,332
active Crohn's disease 17 | 922
adrenocortical carcinoma 17 | 1,428
diabetes mellitus 17 | 1,728
cystic fibrosis 16 | 1,696
Down syndrome 15 | 499
Intellectual disability 15 | 1,016
active ulcerative colitis 15 | 764
cutaneous lupus erythematosus 15 | 1,057
pancreatic carcinoma 15 | 562
primary pancreatic ductal adenocarcinoma 15 | 1,109
Depressive disorder 14 | 409
non primary Sjogren syndrome sicca 14 | 891
dermatomyositis 13 | 966
esophageal adenocarcinoma 13 | 737
nasopharyngeal carcinoma 13 | 1,058
Epilepsy 12 | 792
Melanoma 12 | 711
Muscle hypotonia 12 | 571
Waldenstrons macroglobulinemia 12 | 765
aldosterone-producing adenoma 12 | 665
Cognitive delay 11 | 608
Global developmental delay 11 | 608
Mental and motor retardation 11 | 608
Obesity 11 | 678
Short stature 11 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
Liver Cirrhosis, Experimental 10 | 769
acute myeloid leukemia 10 | 783
chronic rhinosinusitis 10 | 512
Alzheimer's disease 9 | 658
Autistic Disorder 9 | 364
Duchenne muscular dystrophy 9 | 601
Dull intelligence 9 | 645
Endometriosis 9 | 540
Low intelligence 9 | 645
Mental Depression 9 | 333
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Neurodegenerative disease 9 | 414
Poor school performance 9 | 645
gastric carcinoma 9 | 807
primary Sjogren syndrome 9 | 735
sonic hedgehog group medulloblastoma 9 | 467
Amyotrophic lateral sclerosis 8 | 451
Major Depressive Disorder 8 | 301
Mood Disorders 8 | 184
Parkinson's disease 8 | 392
Type 2 diabetes mellitus 8 | 272
Vascular disease 8 | 319
gastric cancer 8 | 459

Tissue

Endocrine System 203 | 18,159
Female tissues 202 | 17,400
Digestive Tract 201 | 17,369
Male tissues 201 | 17,142
Urinary Tract 201 | 16,678
Skin and soft tissues 200 | 17,230
Liver and Pancreas 199 | 16,750
Nervous System 198 | 16,725
Blood and immune system 196 | 16,909
Respiratory system 195 | 16,393
Cardiovascular System 188 | 15,192

Target Family

Non-IDG 110 | 12,091
Enzyme 51 | 4,145
Transcription Factor 13 | 1,400
Epigenetic 8 | 242
Kinase 7 | 634
Transporter 7 | 473
GPCR 6 | 408
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38
Ion Channel 1 | 344

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Choline transporter-like protein 1 SLC44A1 Tbio Transporter -1.60796 43.9 212
TRAF2 and NCK-interacting protein kinase TNIK Tchem Kinase -1.33394 28.5 441
Transmembrane protein 248 TMEM248 Tdark Non-IDG 0.00000 47
Protocadherin-18 PCDH18 Tbio Non-IDG -0.69395 5.31 87
PR domain zinc finger protein 4 PRDM4 Tbio TF/Epigenetic -0.87918 7.84 221
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
CTD small phosphatase-like protein 2 CTDSPL2 Tdark Enzyme -0.57403 3.70 102
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Harmonin USH1C Tbio Non-IDG -2.10689 124.7 188
Cadherin-10 CDH10 Tbio Non-IDG -0.86821 9.34 155