Development Level

Tbio 118 | 10,625
Tdark 37 | 7,003
Tchem 27 | 1,890
Tclin 4 | 602

Collection

Eligible Kinase Proteins 2 | 134
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

decreased total body fat amoun... 186 | 186
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

osteosarcoma 111 | 7,933
ovarian cancer 111 | 8,484
medulloblastoma, large-cell 93 | 6,234
psoriasis 91 | 6,685
glioblastoma 82 | 5,572
atypical teratoid / rhabdoid tumor 64 | 4,369
lung cancer 63 | 4,466
pilocytic astrocytoma 52 | 3,086
primitive neuroectodermal tumor 51 | 3,031
malignant mesothelioma 49 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 44 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,289
pediatric high grade glioma 44 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 43 | 2,988
Pick disease 42 | 1,893
ependymoma 41 | 2,514
oligodendroglioma 41 | 2,849
subependymal giant cell astrocytoma 38 | 2,287
invasive ductal carcinoma 36 | 2,950
pancreatic cancer 35 | 2,300
group 4 medulloblastoma 34 | 1,875
non-small cell lung cancer 34 | 2,798
Breast cancer 33 | 3,094
lung carcinoma 33 | 2,844
Carcinoma 32 | 2,147
astrocytoma 31 | 1,493
lung adenocarcinoma 30 | 2,713
pituitary cancer 30 | 1,972
astrocytic glioma 29 | 2,241
ulcerative colitis 28 | 2,087
interstitial cystitis 25 | 2,299
Cancer 24 | 2,346
ductal carcinoma in situ 24 | 1,745
acute quadriplegic myopathy 23 | 1,157
adult high grade glioma 23 | 2,148
posterior fossa group A ependymoma 23 | 1,511
primary pancreatic ductal adenocarcinoma 22 | 1,271
breast carcinoma 21 | 1,614
cystic fibrosis 21 | 1,665
group 3 medulloblastoma 21 | 2,254
spina bifida 21 | 1,064
juvenile dermatomyositis 20 | 1,189
medulloblastoma 20 | 1,524
sonic hedgehog group medulloblastoma 20 | 1,482
adrenocortical carcinoma 19 | 1,427
Rheumatoid Arthritis 18 | 1,160
atypical teratoid/rhabdoid tumor 18 | 1,095
colon cancer 18 | 1,475
diabetes mellitus 17 | 1,663
tuberculosis 17 | 1,557
esophageal adenocarcinoma 16 | 737
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,795
Down syndrome 14 | 548
progressive supranuclear palsy 14 | 674
Atopic dermatitis 13 | 944
Multiple myeloma 13 | 1,327
dermatomyositis 13 | 933
non primary Sjogren syndrome sicca 13 | 840
aldosterone-producing adenoma 12 | 664
cutaneous lupus erythematosus 12 | 1,056
Alzheimer's disease 11 | 644
gastric carcinoma 11 | 832
nasopharyngeal carcinoma 11 | 1,056
pancreatic carcinoma 11 | 567
Intellectual disability 10 | 573
Neurodegenerative disease 10 | 383
Parkinson's disease 10 | 364
active Crohn's disease 10 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 499
posterior fossa group B ependymoma 10 | 1,530
Amyotrophic Lateral Sclerosis 9 | 431
Duchenne muscular dystrophy 9 | 602
Obesity 9 | 616
Schizophrenia 9 | 501
Waldenstrons macroglobulinemia 8 | 765
nephrosclerosis 8 | 329
non-inflammatory breast cancer 8 | 208
primary Sjogren syndrome 8 | 789
Endometriosis 7 | 535
Epilepsy 7 | 346
active ulcerative colitis 7 | 477
acute myeloid leukemia 7 | 780
hereditary spastic paraplegia 7 | 313
tuberculosis and treatment for 6 months 7 | 686
Bipolar Disorder 6 | 266
chronic rhinosinusitis 6 | 512
urothelial carcinoma 6 | 318
Acquired metabolic disease 5 | 267
Autistic Disorder 5 | 320
Gaucher disease type 1 5 | 171
Juvenile arthritis 5 | 124
Parkinson Disease 5 | 102
Prostatic Neoplasms 5 | 471
Vascular disease 5 | 281
fibroadenoma 5 | 557
gastric cancer 5 | 430
inflammatory breast cancer 5 | 404
interstitial lung disease 5 | 291
sarcoidosis 5 | 358
periodontitis 4 | 269

Tissue

Cardiovascular System 186 | 17,958
Blood and immune system 185 | 17,995
Endocrine System 185 | 18,512
Female tissues 185 | 18,647
Liver and Pancreas 185 | 18,136
Nervous System 185 | 18,561
Digestive Tract 184 | 18,473
Urinary Tract 184 | 18,444
Male tissues 183 | 17,969
Respiratory system 183 | 17,484
Skin and soft tissues 183 | 18,115

Target Family

Non-IDG 102 | 11,971
Enzyme 41 | 4,146
Epigenetic 11 | 242
Transporter 11 | 473
Transcription Factor 8 | 1,400
Kinase 7 | 634
GPCR 3 | 406
TF/Epigenetic 2 | 38
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Cytochrome b-245 light chain CYBA Tbio Non-IDG -2.56294 358.8 154
Sodium-dependent phosphate transporter 2 SLC20A2 Tbio Transporter -2.18737 165.3 97
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Insulin-degrading enzyme IDE Tchem Enzyme -2.54789 384.2 283
V-type proton ATPase 116 kDa subunit a isoform 1 ATP6V0A1 Tbio Enzyme -1.36455 23.7 59
Histone-lysine N-methyltransferase SETD1A SETD1A Tbio Epigenetic -2.53375 346.3 108
Cytochrome b5 domain-containing protein 1 CYB5D1 Tdark Non-IDG -0.09691 1.25 65
Neurocalcin-delta NCALD Tbio Non-IDG -1.29236 20.2 87