Development Level

Tbio 28 | 11,445
Tdark 7 | 6,588
Tchem 5 | 1,598
Tclin 1 | 613

Collection

Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

decreased red blood cell distr... 41 | 41
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 25 | 11,493
ovarian cancer 20 | 8,520
osteosarcoma 18 | 7,950
atypical teratoid / rhabdoid tumor 14 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
Breast cancer 12 | 3,578
glioblastoma 12 | 5,792
psoriasis 12 | 6,694
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
medulloblastoma, large-cell 11 | 6,241
invasive ductal carcinoma 10 | 2,951
lung adenocarcinoma 10 | 2,716
Autosomal recessive predisposition 9 | 1,442
ependymoma 9 | 4,679
group 3 medulloblastoma 9 | 4,104
Cancer 8 | 2,499
Kidney cancer 8 | 2,613
adult high grade glioma 8 | 3,801
lung cancer 7 | 4,740
lung carcinoma 7 | 2,843
non-small cell lung cancer 7 | 2,890
primitive neuroectodermal tumor 7 | 3,035
Astrocytoma, Pilocytic 6 | 3,081
astrocytic glioma 6 | 2,597
group 4 medulloblastoma 6 | 1,855
interstitial cystitis 6 | 2,312
pancreatic cancer 6 | 2,398
subependymal giant cell astrocytoma 6 | 2,287
Multiple myeloma 5 | 1,332
Pick disease 5 | 1,894
Schizophrenia 5 | 1,160
active Crohn's disease 5 | 922
adrenocortical carcinoma 5 | 1,428
breast carcinoma 5 | 1,638
juvenile dermatomyositis 5 | 1,187
malignant mesothelioma 5 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
ulcerative colitis 5 | 1,819
Liver cancer 4 | 604
active ulcerative colitis 4 | 764
cutaneous lupus erythematosus 4 | 1,057
ductal carcinoma in situ 4 | 1,745
oligodendroglioma 4 | 2,850
Amyotrophic lateral sclerosis 3 | 451
Dysarthria 3 | 192
Liver Cirrhosis, Experimental 3 | 769
Melanoma 3 | 711
Muscle hypotonia 3 | 571
Neurodegenerative disease 3 | 414
Obesity 3 | 678
Skin cancer 3 | 469
acute quadriplegic myopathy 3 | 1,158
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
diabetes mellitus 3 | 1,728
hepatocellular carcinoma 3 | 547
nasopharyngeal carcinoma 3 | 1,058
tuberculosis 3 | 2,010
Arthritis, Juvenile 2 | 126
Atopic dermatitis 2 | 952
Autistic Disorder 2 | 364
Broad flat nasal bridge 2 | 236
Concave bridge of nose 2 | 195
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Dilated ventricles (finding) 2 | 121
Down syndrome 2 | 499
Duchenne muscular dystrophy 2 | 601
Endometriosis 2 | 540
Frontal bossing 2 | 157
Heart failure 2 | 162
Infantile onset 2 | 238
Joint hyperflexibility 2 | 78
Juvenile arthritis 2 | 126
Lung Neoplasms 2 | 232
Nasal bridge wide 2 | 236
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
Osteoporosis 2 | 363
Rheumatoid arthritis 2 | 1,191
Sensorineural Hearing Loss (disorder) 2 | 284
Skeletal muscle atrophy 2 | 139
Strabismus 2 | 270
Type 2 diabetes mellitus 2 | 272
Vascular disease 2 | 319
Waldenstrons macroglobulinemia 2 | 765
aldosterone-producing adenoma 2 | 665
astrocytoma 2 | 1,146
dermatomyositis 2 | 966
esophageal adenocarcinoma 2 | 737
fibroadenoma 2 | 559
medulloblastoma 2 | 720
muscle degeneration 2 | 139
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676
spina bifida 2 | 1,074
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 40 | 16,909
Endocrine System 40 | 18,159
Female tissues 40 | 17,400
Liver and Pancreas 40 | 16,750
Digestive Tract 39 | 17,369
Skin and soft tissues 39 | 17,230
Urinary Tract 39 | 16,678
Male tissues 38 | 17,142
Nervous System 38 | 16,725
Respiratory system 38 | 16,393
Cardiovascular System 37 | 15,192

Target Family

Non-IDG 20 | 12,091
Enzyme 12 | 4,145
Epigenetic 3 | 242
Ion Channel 2 | 344
Transporter 2 | 473
TF/Epigenetic 1 | 38
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
F-box/LRR-repeat protein 2 FBXL2 Tbio Non-IDG -0.89339 8.63 129
Vacuolar protein sorting-associated protein 13A VPS13A Tbio Non-IDG -2.19966 172.3 22
FXYD domain-containing ion transport regulator 3 FXYD3 Tbio Ion Channel -1.78093 58.4 76
Glycine amidinotransferase, mitochondrial GATM Tbio Enzyme -2.34742 219.1 219
E3 ubiquitin-protein ligase TRIM37 TRIM37 Tbio Enzyme -3.25892 1754.8 177
Centrosomal protein of 55 kDa CEP55 Tbio Non-IDG -1.49634 36.2 207
Atlastin-2 ATL2 Tbio Non-IDG -1.20941 15.1 91
Cytochrome b ascorbate-dependent protein 3 CYB561A3 Tdark Non-IDG 0.03 1.21 6
Integrator complex subunit 6-like INTS6L Tdark Non-IDG 0.39 0.32 28