Development Level

Tbio 61 | 11,445
Tchem 10 | 1,598
Tdark 9 | 6,588
Tclin 2 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

decreased prepulse inhibition 82 | 82
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 63 | 11,493
osteosarcoma 45 | 7,950
atypical teratoid / rhabdoid tumor 40 | 5,112
ovarian cancer 39 | 8,520
glioblastoma 38 | 5,792
psoriasis 35 | 6,694
medulloblastoma, large-cell 33 | 6,241
ependymoma 29 | 4,679
adult high grade glioma 28 | 3,801
lung cancer 28 | 4,740
group 3 medulloblastoma 26 | 4,104
primitive neuroectodermal tumor 26 | 3,035
invasive ductal carcinoma 24 | 2,951
Breast cancer 21 | 3,578
malignant mesothelioma 21 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
Pick disease 19 | 1,894
Astrocytoma, Pilocytic 18 | 3,081
ductal carcinoma in situ 18 | 1,745
Kidney cancer 17 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
non-small cell lung cancer 17 | 2,890
Cancer 16 | 2,499
astrocytic glioma 16 | 2,597
interstitial cystitis 15 | 2,312
pancreatic cancer 14 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Schizophrenia 12 | 1,160
lung adenocarcinoma 12 | 2,716
lung carcinoma 12 | 2,843
pediatric high grade glioma 12 | 1,064
pituitary cancer 12 | 1,972
spina bifida 12 | 1,074
adrenocortical carcinoma 11 | 1,428
group 4 medulloblastoma 11 | 1,855
oligodendroglioma 11 | 2,850
Epilepsy 10 | 792
breast carcinoma 10 | 1,638
cystic fibrosis 10 | 1,696
subependymal giant cell astrocytoma 10 | 2,287
ulcerative colitis 10 | 1,819
Autosomal recessive predisposition 9 | 1,442
colon cancer 9 | 1,478
tuberculosis 9 | 2,010
Atopic dermatitis 8 | 952
Intellectual disability 8 | 1,016
primary pancreatic ductal adenocarcinoma 8 | 1,109
Alzheimer's disease 7 | 658
dermatomyositis 7 | 966
Bipolar Disorder 6 | 666
Depressive disorder 6 | 409
Dull intelligence 6 | 645
Low intelligence 6 | 645
Melanoma 6 | 711
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Nonsyndromic deafness 6 | 142
Poor school performance 6 | 645
Seizures 6 | 596
Short stature 6 | 531
Skin cancer 6 | 469
acute quadriplegic myopathy 6 | 1,158
cutaneous lupus erythematosus 6 | 1,057
esophageal adenocarcinoma 6 | 737
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Hypertension 5 | 396
Liver cancer 5 | 604
Mental and motor retardation 5 | 608
Mood Disorders 5 | 184
astrocytoma 5 | 1,146
fibroadenoma 5 | 559
gastric carcinoma 5 | 807
juvenile dermatomyositis 5 | 1,187
posterior fossa group A ependymoma 5 | 468
primary Sjogren syndrome 5 | 735
progressive supranuclear palsy 5 | 676
sonic hedgehog group medulloblastoma 5 | 467
Breast Neoplasms 4 | 445
Down syndrome 4 | 499
Duchenne muscular dystrophy 4 | 601
Hypertensive disease 4 | 292
Mental Depression 4 | 333
Muscle hypotonia 4 | 571
Obesity 4 | 678
Osteoporosis 4 | 363
Parkinson's disease 4 | 392
Type 2 diabetes mellitus 4 | 272
acute myeloid leukemia 4 | 783
chronic rhinosinusitis 4 | 512
diabetes mellitus 4 | 1,728
facioscapulohumeral dystrophy 4 | 288
Chronic Lymphocytic Leukemia 3 | 262
Curvature of spine 3 | 282
Rheumatoid arthritis 3 | 1,191
Waldenstrons macroglobulinemia 3 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
hepatocellular carcinoma 3 | 547
urothelial carcinoma 3 | 318

Tissue

Endocrine System 81 | 18,159
Skin and soft tissues 81 | 17,230
Digestive Tract 79 | 17,369
Liver and Pancreas 79 | 16,750
Female tissues 78 | 17,400
Male tissues 78 | 17,142
Respiratory system 77 | 16,393
Nervous System 76 | 16,725
Urinary Tract 76 | 16,678
Blood and immune system 75 | 16,909
Cardiovascular System 72 | 15,192

Target Family

Non-IDG 44 | 12,091
Enzyme 13 | 4,145
Transcription Factor 6 | 1,400
Kinase 5 | 634
Transporter 5 | 473
Epigenetic 3 | 242
GPCR 3 | 408
Ion Channel 1 | 344
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
F-box only protein 11 FBXO11 Tbio Non-IDG -1.53905 34.1 258
Caskin-1 CASKIN1 Tdark Non-IDG -0.63111 5.31 22
G-protein coupled receptor 98 ADGRV1 Tbio GPCR -2.51228 316.6 64
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Beta/gamma crystallin domain-containing protein 1 CRYBG1 Tbio Non-IDG -1.13797 12.4 13
Lysosomal-associated transmembrane protein 4B LAPTM4B Tbio Non-IDG -1.90763 86.1 91
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Histone-lysine N-methyltransferase NSD3 NSD3 Tbio Epigenetic -1.36629 23.0 234