Development Level

Tbio 23 | 11,445
Tchem 10 | 1,598
Tdark 6 | 6,588
Tclin 3 | 613

IMPC Phenotype

decreased neutrophil cell numb... 42 | 42
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 29 | 11,493
ovarian cancer 21 | 8,520
medulloblastoma, large-cell 19 | 6,241
psoriasis 19 | 6,694
glioblastoma 18 | 5,792
osteosarcoma 18 | 7,950
atypical teratoid / rhabdoid tumor 17 | 5,112
ependymoma 15 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
Cancer 13 | 2,499
astrocytic glioma 11 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
oligodendroglioma 11 | 2,850
Pick disease 10 | 1,894
adult high grade glioma 10 | 3,801
malignant mesothelioma 10 | 3,232
Autosomal recessive predisposition 9 | 1,442
group 3 medulloblastoma 9 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
lung cancer 9 | 4,740
Breast cancer 8 | 3,578
invasive ductal carcinoma 8 | 2,951
lung carcinoma 8 | 2,843
Astrocytoma, Pilocytic 7 | 3,081
Kidney cancer 7 | 2,613
Schizophrenia 7 | 1,160
group 4 medulloblastoma 7 | 1,855
non-small cell lung cancer 7 | 2,890
primitive neuroectodermal tumor 7 | 3,035
subependymal giant cell astrocytoma 7 | 2,287
tuberculosis 7 | 2,010
Multiple myeloma 6 | 1,332
juvenile dermatomyositis 6 | 1,187
progressive supranuclear palsy 6 | 676
ulcerative colitis 6 | 1,819
Breast Neoplasms 5 | 445
Mammary Neoplasms 5 | 425
acute quadriplegic myopathy 5 | 1,158
breast carcinoma 5 | 1,638
dermatomyositis 5 | 966
diabetes mellitus 5 | 1,728
lung adenocarcinoma 5 | 2,716
pancreatic cancer 5 | 2,398
pituitary cancer 5 | 1,972
Atopic dermatitis 4 | 952
Intellectual disability 4 | 1,016
active Crohn's disease 4 | 922
adrenocortical carcinoma 4 | 1,428
astrocytoma 4 | 1,146
ductal carcinoma in situ 4 | 1,745
nasopharyngeal carcinoma 4 | 1,058
primary pancreatic ductal adenocarcinoma 4 | 1,109
Alzheimer's disease 3 | 658
Amyotrophic lateral sclerosis 3 | 451
Bipolar Disorder 3 | 666
Down syndrome 3 | 499
Dull intelligence 3 | 645
Dysarthria 3 | 192
Hypoplastic mandible condyle 3 | 275
Low intelligence 3 | 645
Mandibular hypoplasia 3 | 275
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Micrognathism 3 | 275
Myopathy 3 | 185
Orbital separation excessive 3 | 244
Parkinson's disease 3 | 392
Poor school performance 3 | 645
Rheumatoid arthritis 3 | 1,191
Short nose 3 | 132
Short stature 3 | 531
Small nose 3 | 132
Waldenstrons macroglobulinemia 3 | 765
acute myeloid leukemia 3 | 783
aldosterone-producing adenoma 3 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
colon cancer 3 | 1,478
fibroadenoma 3 | 559
interstitial cystitis 3 | 2,312
non primary Sjogren syndrome sicca 3 | 891
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
tuberculosis and treatment for 6 months 3 | 409
Acquired scoliosis 2 | 281
Broad flat nasal bridge 2 | 236
Concave bridge of nose 2 | 195
Coronary artery disease 2 | 268
Curvature of spine 2 | 282
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Endometriosis 2 | 540
Epilepsy 2 | 792
Inflammatory bowel disease 2 | 151
Lung disease 2 | 142
Malaria 2 | 160
Nasal bridge wide 2 | 236
Strabismus 2 | 270
Unipolar Depression 2 | 250
cystic fibrosis 2 | 1,696
medulloblastoma 2 | 720
pediatric high grade glioma 2 | 1,064

Tissue

Blood and immune system 42 | 16,909
Skin and soft tissues 42 | 17,230
Digestive Tract 41 | 17,369
Endocrine System 41 | 18,159
Female tissues 41 | 17,400
Liver and Pancreas 41 | 16,750
Cardiovascular System 40 | 15,192
Male tissues 39 | 17,142
Nervous System 39 | 16,725
Respiratory system 39 | 16,393
Urinary Tract 39 | 16,678

Target Family

Non-IDG 21 | 12,091
Enzyme 11 | 4,145
Kinase 4 | 634
Ion Channel 2 | 344
Epigenetic 1 | 242
GPCR 1 | 408
Nuclear Receptor 1 | 48
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Melanocyte-stimulating hormone receptor MC1R Tclin GPCR -2.90014 829.2 194
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Carboxypeptidase A1 CPA1 Tchem Enzyme -1.95541 84.1 265
E3 ubiquitin-protein ligase TRIM37 TRIM37 Tbio Enzyme -3.25892 1754.8 177
Synaptojanin-1 SYNJ1 Tbio Non-IDG -1.76329 62.0 93
Basal body-orientation factor 1 BBOF1 Tdark Non-IDG 0.30 0.89 26
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.24422 170.7 75
Atlastin-2 ATL2 Tbio Non-IDG -1.20941 15.1 91
Integrin alpha-E ITGAE Tbio Non-IDG -2.61450 414.3 758
Matrix-remodeling-associated protein 7 MXRA7 Tdark Non-IDG -0.42325 2.23 23