Development Level

Tbio 55 | 11,445
Tchem 14 | 1,598
Tdark 10 | 6,588
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

decreased lymphocyte cell numb... 83 | 83
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 55 | 11,493
osteosarcoma 48 | 7,950
ovarian cancer 46 | 8,520
medulloblastoma, large-cell 42 | 6,241
glioblastoma 39 | 5,792
psoriasis 36 | 6,694
atypical teratoid / rhabdoid tumor 34 | 5,112
ependymoma 29 | 4,679
lung cancer 26 | 4,740
adult high grade glioma 23 | 3,801
Astrocytoma, Pilocytic 21 | 3,081
malignant mesothelioma 21 | 3,232
Kidney cancer 20 | 2,613
astrocytic glioma 20 | 2,597
interstitial cystitis 20 | 2,312
lung carcinoma 20 | 2,843
non-small cell lung cancer 20 | 2,890
primitive neuroectodermal tumor 20 | 3,035
group 3 medulloblastoma 19 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
Pick disease 18 | 1,894
invasive ductal carcinoma 18 | 2,951
oligodendroglioma 18 | 2,850
Cancer 17 | 2,499
group 4 medulloblastoma 17 | 1,855
Breast cancer 15 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
lung adenocarcinoma 15 | 2,716
pancreatic cancer 14 | 2,398
primary Sjogren syndrome 14 | 735
ulcerative colitis 14 | 1,819
Autosomal recessive predisposition 13 | 1,442
subependymal giant cell astrocytoma 13 | 2,287
cutaneous lupus erythematosus 12 | 1,057
pituitary cancer 12 | 1,972
tuberculosis 12 | 2,010
cystic fibrosis 11 | 1,696
Schizophrenia 10 | 1,160
periodontitis 10 | 293
colon cancer 9 | 1,478
diabetes mellitus 9 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Multiple myeloma 8 | 1,332
acute quadriplegic myopathy 8 | 1,158
adrenocortical carcinoma 8 | 1,428
ductal carcinoma in situ 8 | 1,745
hepatocellular carcinoma 8 | 547
nasopharyngeal carcinoma 8 | 1,058
progressive supranuclear palsy 8 | 676
Liver cancer 7 | 604
Melanoma 7 | 711
Rheumatoid arthritis 7 | 1,191
breast carcinoma 7 | 1,638
juvenile dermatomyositis 7 | 1,187
pancreatic carcinoma 7 | 562
spina bifida 7 | 1,074
Acquired metabolic disease 6 | 336
Asthma 6 | 385
Autistic Disorder 6 | 364
Bipolar Disorder 6 | 666
Gaucher disease type 1 6 | 180
Obesity 6 | 678
Chronic Lymphocytic Leukemia 5 | 262
Hypertension 5 | 396
Intellectual disability 5 | 1,016
Muscle hypotonia 5 | 571
Neurodegenerative disease 5 | 414
Systemic lupus erythematosus 5 | 194
active Crohn's disease 5 | 922
acute myeloid leukemia 5 | 783
chronic rhinosinusitis 5 | 512
esophageal adenocarcinoma 5 | 737
gastric carcinoma 5 | 807
medulloblastoma 5 | 720
sarcoidosis 5 | 370
Amyotrophic lateral sclerosis 4 | 451
Atopic dermatitis 4 | 952
Endometrial cancer 4 | 311
Epilepsy 4 | 792
Hypertensive disease 4 | 292
Inflammatory bowel disease 4 | 151
Liver Cirrhosis, Experimental 4 | 769
Skin cancer 4 | 469
active ulcerative colitis 4 | 764
astrocytoma 4 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
dermatomyositis 4 | 966
gastric cancer 4 | 459
pediatric high grade glioma 4 | 1,064
Allergic hypersensitivity disease 3 | 126
Anorexia nervosa 3 | 80
Arthritis, Rheumatoid 3 | 174
Mental Depression 3 | 333
Prostatic Neoplasms 3 | 495
Strabismus 3 | 270
Waldenstrons macroglobulinemia 3 | 765
fibroadenoma 3 | 559
mucosa-associated lymphoid tissue lymphoma 3 | 484
sonic hedgehog group medulloblastoma 3 | 467

Tissue

Endocrine System 82 | 18,159
Female tissues 82 | 17,400
Male tissues 82 | 17,142
Skin and soft tissues 82 | 17,230
Urinary Tract 82 | 16,678
Blood and immune system 81 | 16,909
Digestive Tract 81 | 17,369
Liver and Pancreas 80 | 16,750
Respiratory system 80 | 16,393
Nervous System 79 | 16,725
Cardiovascular System 75 | 15,192

Target Family

Non-IDG 43 | 12,091
Enzyme 19 | 4,145
Kinase 6 | 634
Transcription Factor 6 | 1,400
Transporter 4 | 473
Ion Channel 3 | 344
Epigenetic 1 | 242
GPCR 1 | 408

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neurexin-1 NRXN1 Tbio Non-IDG -1.88807 125.1 174
ER membrane protein complex subunit 10 EMC10 Tbio Non-IDG -1.41680 25.5 60
Poly(ADP-ribose) glycohydrolase PARG Tchem Enzyme -2.32776 229.4 126
Pre-mRNA-splicing factor CWC22 homolog CWC22 Tbio Non-IDG -3.08456 1172.8 103
Tyrosine-protein kinase TXK TXK Tchem Kinase -2.28365 191.1 194
Phospholipase ABHD3 ABHD3 Tbio Enzyme -0.41218 2.23 91
Cellular retinoic acid-binding protein 1 CRABP1 Tbio Non-IDG -2.48395 306.2 152
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha PDE6A Tclin Enzyme -1.29228 20.3 111
ETS domain-containing transcription factor ERF ERF Tbio Transcription Factor -2.42588 268.8 257
E3 ubiquitin-protein ligase TRIM37 TRIM37 Tbio Enzyme -3.25892 1754.8 177