Development Level

Tbio 10 | 11,445
Tdark 3 | 6,588
Tchem 2 | 1,598
Tclin 1 | 613

IMPC Phenotype

decreased lactate dehydrogenas... 16 | 16
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 13 | 11,493
ovarian cancer 11 | 8,520
atypical teratoid / rhabdoid tumor 9 | 5,112
medulloblastoma, large-cell 9 | 6,241
osteosarcoma 9 | 7,950
glioblastoma 7 | 5,792
Breast cancer 6 | 3,578
ependymoma 6 | 4,679
psoriasis 6 | 6,694
Astrocytoma, Pilocytic 5 | 3,081
lung cancer 5 | 4,740
oligodendroglioma 5 | 2,850
Cancer 4 | 2,499
Kidney cancer 4 | 2,613
Pick disease 4 | 1,894
Polycystic ovary syndrome 4 | 360
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
diabetes mellitus 4 | 1,728
subependymal giant cell astrocytoma 4 | 2,287
Alzheimer's disease 3 | 658
Cognitive delay 3 | 608
Global developmental delay 3 | 608
Mental and motor retardation 3 | 608
Obesity 3 | 678
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
invasive ductal carcinoma 3 | 2,951
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
pituitary cancer 3 | 1,972
tuberculosis 3 | 2,010
Alzheimer Disease 2 | 83
Autosomal recessive predisposition 2 | 1,442
Blepharoptosis 2 | 231
Breast Neoplasms 2 | 445
Dull intelligence 2 | 645
Hypertrichosis 2 | 46
Hypertrophic Cardiomyopathy 2 | 117
Immune system cancer 2 | 140
Impaired exercise tolerance 2 | 42
Increased serum lactate 2 | 60
Intellectual disability 2 | 1,016
Liver cancer 2 | 604
Low intelligence 2 | 645
Lymphoid leukemia 2 | 160
Mammary Neoplasms 2 | 425
Melanoma 2 | 711
Mental Depression 2 | 333
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Mood Disorders 2 | 184
Multiple myeloma 2 | 1,332
Muscle Weakness 2 | 170
Poor school performance 2 | 645
Rheumatoid arthritis 2 | 1,191
Type 2 diabetes mellitus 2 | 272
Waldenstrons macroglobulinemia 2 | 765
Weight Gain 2 | 100
astrocytoma 2 | 1,146
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
ductal carcinoma in situ 2 | 1,745
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung adenocarcinoma 2 | 2,716
medulloblastoma 2 | 720
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
spina bifida 2 | 1,074
Abnormal respiratory patterns 1 | 20
Birthmark 1 | 35
Cafe-au-Lait Spots 1 | 37
Decreased projection of midface 1 | 105
Defective enamel matrix 1 | 35
Dental Enamel Hypoplasia 1 | 43
Doyne honeycomb retinal dystrophy 1 | 9
Dysplasia of tooth enamel 1 | 35
Esophagitis 1 | 35
Fetal overgrowth 1 | 16
Fractures, Bone 1 | 13
Generalized overgrowth 1 | 16
Hepatocellular necrosis 1 | 14
Hyperglycemia 1 | 137
Hypotrophic midface 1 | 105
Leigh syndrome 1 | 28
Li-Fraumeni syndrome 1 | 13
Liposarcoma 1 | 20
Malignant peripheral nerve sheath tumor 1 | 12
Muscle Cramp 1 | 55
Muscle Rigidity 1 | 49
Neurofibromatosis 1 | 40
Overgrowth 1 | 16
Persistent generalized lymphadenopathy 1 | 15
Phaeochromocytoma 1 | 20
Pheochromocytoma 1 | 24
Relative macrocephaly 1 | 12
Scoliosis 1 | 44
Thin dental enamel 1 | 35

Tissue

Blood and immune system 16 | 16,909
Cardiovascular System 16 | 15,192
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678

Target Family

Non-IDG 9 | 12,091
Enzyme 6 | 4,145
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
Insulin-degrading enzyme IDE Tchem Enzyme -2.57779 392.8 331
Neurofibromin NF1 Tbio Non-IDG -3.60161 4054.2 355
Protein FAM110B FAM110B Tdark Non-IDG -0.03110 1.29 47
Alpha-ketoglutarate-dependent dioxygenase FTO FTO Tbio Enzyme -3.13021 1342.0 318
Conserved oligomeric Golgi complex subunit 2 COG2 Tbio Non-IDG -3.65712 4250.6 169
L-lactate dehydrogenase A chain LDHA Tchem Enzyme -3.03454 1030.5 577
Intraflagellar transport protein 20 homolog IFT20 Tbio Non-IDG -1.18376 15.2 90
Spectrin beta chain, non-erythrocytic 1 SPTBN1 Tbio Non-IDG -1.69564 46.5 98
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma AGPAT3 Tbio Enzyme -1.10226 13.9 108