Development Level

Tbio 31 | 11,651
Tdark 11 | 6,593
Tchem 2 | 1,388
Tclin 2 | 612

Collection

RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

decreased hematocrit 46 | 46
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 30 | 11,493
osteosarcoma 25 | 7,950
ovarian cancer 23 | 8,520
medulloblastoma, large-cell 22 | 6,241
psoriasis 20 | 6,694
glioblastoma 19 | 5,792
atypical teratoid / rhabdoid tumor 18 | 5,112
lung cancer 16 | 4,740
ependymoma 15 | 4,679
Astrocytoma, Pilocytic 13 | 3,081
adult high grade glioma 13 | 3,801
Cancer 12 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
astrocytic glioma 10 | 2,597
lung adenocarcinoma 10 | 2,716
ulcerative colitis 10 | 1,819
Pick disease 9 | 1,894
group 3 medulloblastoma 9 | 4,104
non-small cell lung cancer 9 | 2,890
primitive neuroectodermal tumor 9 | 3,035
Breast cancer 8 | 3,578
interstitial cystitis 8 | 2,312
lung carcinoma 8 | 2,843
malignant mesothelioma 8 | 3,232
Kidney cancer 7 | 2,613
group 4 medulloblastoma 7 | 1,855
invasive ductal carcinoma 7 | 2,951
subependymal giant cell astrocytoma 7 | 2,287
primary Sjogren syndrome 6 | 735
tuberculosis 6 | 2,010
Melanoma 5 | 711
colon cancer 5 | 1,478
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
medulloblastoma 5 | 720
oligodendroglioma 5 | 2,850
pediatric high grade glioma 5 | 1,064
pituitary cancer 5 | 1,972
progressive supranuclear palsy 5 | 676
Skin cancer 4 | 469
astrocytoma 4 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
juvenile dermatomyositis 4 | 1,187
spina bifida 4 | 1,074
tuberculosis and treatment for 6 months 4 | 409
Autosomal recessive predisposition 3 | 1,442
Endometriosis 3 | 540
Liver Cirrhosis, Experimental 3 | 769
Osteoporosis 3 | 363
Rheumatoid arthritis 3 | 1,191
Schizophrenia 3 | 1,160
active Crohn's disease 3 | 922
acute myeloid leukemia 3 | 783
adrenocortical carcinoma 3 | 1,428
cutaneous lupus erythematosus 3 | 1,057
cystic fibrosis 3 | 1,696
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
gastric cancer 3 | 459
hepatocellular carcinoma 3 | 547
hereditary spastic paraplegia 3 | 318
nasopharyngeal carcinoma 3 | 1,058
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
sarcoidosis 3 | 370
Alzheimer's disease 2 | 658
Arthritis, Rheumatoid 2 | 174
Autosomal recessive polycystic kidney disease 2 | 41
Bipolar Disorder 2 | 666
Colonic Neoplasms 2 | 142
Depressive disorder 2 | 409
Down syndrome 2 | 499
Dysarthria 2 | 192
Extrapyramidal Disorders 2 | 29
Extrapyramidal sign 2 | 29
Gamma chain deficiency 2 | 7
Hypertension 2 | 396
Infantile onset 2 | 238
Leukemia 2 | 104
Lymphoid leukemia 2 | 160
MYELODYSPLASTIC SYNDROME 2 | 53
Multiple Sclerosis 2 | 540
Multiple myeloma 2 | 1,332
Neurodegenerative disease 2 | 414
Radioulnar synostosis 2 | 35
Recurrent infections 2 | 48
Tremor 2 | 113
Vitiligo 2 | 73
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
breast carcinoma 2 | 1,638
chronic rhinosinusitis 2 | 512
esophageal adenocarcinoma 2 | 737
facioscapulohumeral dystrophy 2 | 288
head and neck cancer and chronic obstructive pulmonary disease 2 | 239
mucosa-associated lymphoid tissue lymphoma 2 | 484
non primary Sjogren syndrome sicca 2 | 891
posterior fossa group B ependymoma 2 | 416
primary pancreatic ductal adenocarcinoma 2 | 1,109
urothelial carcinoma 2 | 318

Tissue

Endocrine System 45 | 18,159
Digestive Tract 44 | 17,369
Female tissues 44 | 17,400
Skin and soft tissues 44 | 17,230
Blood and immune system 43 | 16,909
Liver and Pancreas 43 | 16,750
Male tissues 43 | 17,142
Nervous System 43 | 16,725
Cardiovascular System 42 | 15,192
Urinary Tract 42 | 16,678
Respiratory system 41 | 16,393

Target Family

Non-IDG 26 | 12,091
Enzyme 6 | 4,145
Kinase 5 | 634
Transcription Factor 3 | 1,400
Transporter 2 | 473
Epigenetic 1 | 242
GPCR 1 | 408
Ion Channel 1 | 344
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphatase and actin regulator 1 PHACTR1 Tbio Enzyme -1.79171 63.2 41
Dynactin subunit 5 DCTN5 Tdark Non-IDG -0.32495 0.71 53
5'-AMP-activated protein kinase subunit beta-1 PRKAB1 Tbio Kinase -1.52519 32.5 532
StAR-related lipid transfer protein 13 STARD13 Tbio Non-IDG -2.03717 75.4 82
Diphthine--ammonia ligase DPH6 Tbio Enzyme -0.46524 3.27 31
F-box only protein 7 FBXO7 Tbio Non-IDG -2.07231 118.6 100
Caskin-1 CASKIN1 Tdark Non-IDG -0.63111 5.31 22
Ceruloplasmin CP Tbio Non-IDG -2.88089 683.9 251
Oncostatin-M OSM Tbio Non-IDG -2.54044 421.5 433
Histone H2A deubiquitinase MYSM1 MYSM1 Tbio Transcription Factor -1.76987 62.1 184