Development Level

Tbio 9 | 11,445
Tdark 5 | 6,588
Tchem 4 | 1,598

IMPC Phenotype

decreased heart rate 18 | 18
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 13 | 11,493
ovarian cancer 9 | 8,520
group 3 medulloblastoma 7 | 4,104
medulloblastoma, large-cell 6 | 6,241
osteosarcoma 6 | 7,950
Autosomal recessive predisposition 5 | 1,442
atypical teratoid / rhabdoid tumor 5 | 5,112
Breast cancer 4 | 3,578
Cancer 4 | 2,499
Intellectual disability 4 | 1,016
Kidney cancer 4 | 2,613
Seizures 4 | 596
ependymoma 4 | 4,679
glioblastoma 4 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung cancer 4 | 4,740
primitive neuroectodermal tumor 4 | 3,035
Astrocytoma, Pilocytic 3 | 3,081
Cerebral atrophy 3 | 178
Congenital clubfoot 3 | 109
Contracture 3 | 96
Contracture of joint 3 | 93
Downward slant of palpebral fissure 3 | 158
Dull intelligence 3 | 645
Epilepsy 3 | 792
Flexion contracture 3 | 93
Flexion contractures of joints 3 | 93
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Poor school performance 3 | 645
Short stature 3 | 531
adult high grade glioma 3 | 3,801
breast carcinoma 3 | 1,638
invasive ductal carcinoma 3 | 2,951
lung carcinoma 3 | 2,843
oligodendroglioma 3 | 2,850
tuberculosis 3 | 2,010
Abdominal Pain 2 | 98
Anteverted nostril 2 | 191
Brachycephaly 2 | 88
Broad cranium shape 2 | 88
Broad flat nasal bridge 2 | 236
Byzanthine arch palate 2 | 194
Coarse facial features 2 | 108
Cognitive delay 2 | 608
Concave bridge of nose 2 | 195
Congenital hypoplasia of penis 2 | 176
Coronary artery disease 2 | 268
Decreased projection of midface 2 | 105
Dental caries 2 | 164
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Dilated ventricles (finding) 2 | 121
Global developmental delay 2 | 608
Heart disease 2 | 306
Hypertension 2 | 396
Hypoplasia of corpus callosum 2 | 90
Hypoplasia of scrotum 2 | 24
Hypoplastic labia minora 2 | 10
Hypotrophic malar bone 2 | 129
Hypotrophic midface 2 | 105
Kidney disease 2 | 430
Leukemia, Myelocytic, Acute 2 | 120
Malar flattening 2 | 129
Mental and motor retardation 2 | 608
Microcephaly 2 | 166
Midface retrusion 2 | 105
Muscle Weakness 2 | 170
Nasal bridge wide 2 | 236
Pointed chin 2 | 33
Postnatal growth retardation 2 | 57
Rheumatoid arthritis 2 | 1,191
Rotting teeth 2 | 73
Schizophrenia 2 | 1,160
Severe mental retardation (I.Q. 20-34) 2 | 99
Short nose 2 | 132
Short philtrum 2 | 53
Small head 2 | 374
Small labia majora 2 | 16
Small midface 2 | 105
Small nose 2 | 132
Thickened facial skin with coarse facial features 2 | 108
Wide skull shape 2 | 88
astrocytoma 2 | 1,146
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
gastric cancer 2 | 459
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung adenocarcinoma 2 | 2,716
pituitary cancer 2 | 1,972
psoriasis 2 | 6,694
ulcerative colitis 2 | 1,819
Abnormal dermatoglyphic pattern 1 | 24
Clitoral hypoplasia 1 | 11
Colitis, Ulcerative 1 | 59
Decreased muscle mass 1 | 28
Vertebrobasilar insufficiency 1 | 9
Xerostomia 1 | 42

Tissue

Blood and immune system 18 | 16,909
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Liver and Pancreas 17 | 16,750
Urinary Tract 17 | 16,678
Cardiovascular System 13 | 15,192

Target Family

Non-IDG 10 | 12,091
Enzyme 5 | 4,145
Epigenetic 1 | 242
GPCR 1 | 408
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase UHRF2 UHRF2 Tbio Epigenetic -1.57250 40.4 202
Scavenger receptor class B member 1 SCARB1 Tchem Non-IDG -2.93920 915.7 378
SET-binding protein SETBP1 Tbio Non-IDG -2.46805 281.6 98
5-oxoprolinase OPLAH Tdark Enzyme 0.00000 39
Pro-thyrotropin-releasing hormone TRH Tbio Non-IDG -3.25312 1828.2 102
Protein WFDC11 WFDC11 Tdark Non-IDG 0.30 0.25 11
AP-4 complex subunit epsilon-1 AP4E1 Tdark Non-IDG -0.66901 5.48 24
Kallikrein-4 KLK4 Tchem Enzyme -3.66176 4527.4 196
WD repeat and SOCS box-containing protein 2 WSB2 Tbio Non-IDG -1.13752 13.3 68
C-C chemokine receptor type 6 CCR6 Tchem GPCR -1.81445 63.7 519