Development Level

Tbio 83 | 10,625
Tdark 21 | 7,003
Tchem 14 | 1,890
Tclin 5 | 602

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

decreased grip strength 123 | 123
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 76 | 8,484
medulloblastoma, large-cell 70 | 6,234
osteosarcoma 61 | 7,933
psoriasis 58 | 6,685
atypical teratoid / rhabdoid tumor 48 | 4,369
glioblastoma 45 | 5,572
lung cancer 33 | 4,466
pilocytic astrocytoma 32 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,289
primitive neuroectodermal tumor 29 | 3,031
lung adenocarcinoma 27 | 2,713
lung carcinoma 27 | 2,844
malignant mesothelioma 27 | 3,162
oligodendroglioma 27 | 2,849
pediatric high grade glioma 26 | 2,712
Breast cancer 24 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,956
invasive ductal carcinoma 24 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,988
non-small cell lung cancer 23 | 2,798
adult high grade glioma 22 | 2,148
subependymal giant cell astrocytoma 22 | 2,287
Cancer 20 | 2,346
Carcinoma 20 | 2,147
astrocytoma 20 | 1,493
pancreatic cancer 20 | 2,300
ependymoma 19 | 2,514
Pick disease 17 | 1,893
group 3 medulloblastoma 17 | 2,254
group 4 medulloblastoma 17 | 1,875
medulloblastoma 17 | 1,524
pituitary cancer 17 | 1,972
astrocytic glioma 16 | 2,241
colon cancer 16 | 1,475
diabetes mellitus 15 | 1,663
interstitial cystitis 14 | 2,299
posterior fossa group A ependymoma 14 | 1,511
Intellectual disability 13 | 573
breast carcinoma 13 | 1,614
sonic hedgehog group medulloblastoma 13 | 1,482
Atopic dermatitis 12 | 944
adrenocortical carcinoma 12 | 1,427
ulcerative colitis 12 | 2,087
juvenile dermatomyositis 11 | 1,189
primary pancreatic ductal adenocarcinoma 11 | 1,271
Down syndrome 10 | 548
Rheumatoid Arthritis 10 | 1,160
aldosterone-producing adenoma 9 | 664
cutaneous lupus erythematosus 9 | 1,056
ductal carcinoma in situ 9 | 1,745
tuberculosis 9 | 1,557
Mammary Neoplasms 8 | 410
Obesity 8 | 616
Schizophrenia 8 | 501
acute quadriplegic myopathy 8 | 1,157
atypical teratoid/rhabdoid tumor 8 | 1,095
cystic fibrosis 8 | 1,665
dermatomyositis 8 | 933
gastric carcinoma 8 | 832
spina bifida 8 | 1,064
Alzheimer's disease 7 | 644
Autistic Disorder 7 | 320
Neurodegenerative disease 7 | 383
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 499
glioblastoma multiforme 7 | 347
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
posterior fossa group B ependymoma 7 | 1,530
Epilepsy 6 | 346
Multiple myeloma 6 | 1,327
primary Sjogren syndrome 6 | 789
sarcoidosis 6 | 358
Bipolar Disorder 5 | 266
Duchenne muscular dystrophy 5 | 602
Parkinson's disease 5 | 364
Prostatic Neoplasms 5 | 471
nephrosclerosis 5 | 329
progressive supranuclear palsy 5 | 674
urothelial carcinoma 5 | 318
Acquired metabolic disease 4 | 267
Amyotrophic Lateral Sclerosis 4 | 431
Brain Ischemia 4 | 87
Colorectal Neoplasms 4 | 217
Diabetes Mellitus, Non-Insulin-Dependent 4 | 157
Gilles de la Tourette syndrome 4 | 47
IGA Glomerulonephritis 4 | 454
Kidney disease 4 | 396
Peripheral Neuropathy 4 | 303
Polycystic Ovary Syndrome 4 | 332
Toxic encephalopathy 4 | 131
active Crohn's disease 4 | 918
active ulcerative colitis 4 | 477
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 557
head and neck cancer and chronic obstructive pulmonary disease 4 | 237
nasopharyngeal carcinoma 4 | 1,056
Becker muscular dystrophy 3 | 187
acute myeloid leukemia 3 | 780
mucosa-associated lymphoid tissue lymphoma 3 | 480
non diabetic and post-ischemic heart failure 3 | 200
pancreatic carcinoma 3 | 567

Tissue

Digestive Tract 122 | 18,473
Nervous System 122 | 18,561
Liver and Pancreas 121 | 18,136
Endocrine System 120 | 18,512
Female tissues 120 | 18,647
Male tissues 120 | 17,969
Urinary Tract 120 | 18,444
Skin and soft tissues 119 | 18,115
Blood and immune system 118 | 17,995
Cardiovascular System 118 | 17,958
Respiratory system 115 | 17,484

Target Family

Non-IDG 75 | 11,971
Enzyme 25 | 4,146
Transcription Factor 7 | 1,400
GPCR 4 | 406
Ion Channel 3 | 341
Kinase 3 | 634
Transporter 3 | 473
Epigenetic 2 | 242
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Amyloid beta A4 protein APP Tchem Non-IDG -3.60404 4118.9 2173
Poly [ADP-ribose] polymerase 1 PARP1 Tclin Enzyme -3.66184 4494.4 1272