Development Level

Tbio 58 | 11,445
Tdark 15 | 6,588
Tchem 7 | 1,598
Tclin 2 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

decreased circulating serum al... 82 | 82
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 52 | 11,493
ovarian cancer 44 | 8,520
osteosarcoma 37 | 7,950
atypical teratoid / rhabdoid tumor 32 | 5,112
psoriasis 32 | 6,694
medulloblastoma, large-cell 31 | 6,241
group 3 medulloblastoma 30 | 4,104
ependymoma 29 | 4,679
glioblastoma 26 | 5,792
lung cancer 25 | 4,740
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
malignant mesothelioma 21 | 3,232
Astrocytoma, Pilocytic 20 | 3,081
primitive neuroectodermal tumor 19 | 3,035
adult high grade glioma 18 | 3,801
oligodendroglioma 18 | 2,850
Breast cancer 17 | 3,578
Kidney cancer 17 | 2,613
Pick disease 17 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
subependymal giant cell astrocytoma 17 | 2,287
interstitial cystitis 14 | 2,312
lung carcinoma 14 | 2,843
pancreatic cancer 14 | 2,398
astrocytic glioma 12 | 2,597
invasive ductal carcinoma 12 | 2,951
lung adenocarcinoma 12 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
astrocytoma 10 | 1,146
group 4 medulloblastoma 10 | 1,855
primary pancreatic ductal adenocarcinoma 10 | 1,109
Intellectual disability 9 | 1,016
non-small cell lung cancer 9 | 2,890
tuberculosis 9 | 2,010
Cancer 8 | 2,499
Rheumatoid arthritis 8 | 1,191
Schizophrenia 8 | 1,160
adrenocortical carcinoma 8 | 1,428
pituitary cancer 8 | 1,972
progressive supranuclear palsy 8 | 676
breast carcinoma 7 | 1,638
esophageal adenocarcinoma 7 | 737
gastric carcinoma 7 | 807
juvenile dermatomyositis 7 | 1,187
non primary Sjogren syndrome sicca 7 | 891
spina bifida 7 | 1,074
Autosomal recessive predisposition 6 | 1,442
Down syndrome 6 | 499
Melanoma 6 | 711
Skin cancer 6 | 469
colon cancer 6 | 1,478
cutaneous lupus erythematosus 6 | 1,057
diabetes mellitus 6 | 1,728
ulcerative colitis 6 | 1,819
Autistic Disorder 5 | 364
Neurodegenerative disease 5 | 414
acute myeloid leukemia 5 | 783
aldosterone-producing adenoma 5 | 665
ductal carcinoma in situ 5 | 1,745
fibroadenoma 5 | 559
pediatric high grade glioma 5 | 1,064
Alzheimer's disease 4 | 658
Atopic dermatitis 4 | 952
Bipolar Disorder 4 | 666
Cognitive delay 4 | 608
Dementia 4 | 175
Epilepsy 4 | 792
Global developmental delay 4 | 608
Hepatomegaly 4 | 285
Liver cancer 4 | 604
Mental and motor retardation 4 | 608
Obesity 4 | 678
Parkinson's disease 4 | 392
Seizures 4 | 596
Waldenstrons macroglobulinemia 4 | 765
active Crohn's disease 4 | 922
acute quadriplegic myopathy 4 | 1,158
inflammatory breast cancer 4 | 286
nasopharyngeal carcinoma 4 | 1,058
Carcinoma, Hepatocellular 3 | 228
Concave bridge of nose 3 | 195
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Duchenne muscular dystrophy 3 | 601
Dull intelligence 3 | 645
Endometrial cancer 3 | 311
Failure to gain weight 3 | 365
Hyperreflexia 3 | 209
Kidney disease 3 | 430
Liver carcinoma 3 | 240
Pediatric failure to thrive 3 | 365
Polycystic ovary syndrome 3 | 360
Strabismus 3 | 270
active ulcerative colitis 3 | 764
atypical teratoid/rhabdoid tumor 3 | 357
cystic fibrosis 3 | 1,696
nephrosclerosis 3 | 333
posterior fossa group B ependymoma 3 | 416
primary Sjogren syndrome 3 | 735

Tissue

Endocrine System 82 | 18,159
Male tissues 82 | 17,142
Digestive Tract 81 | 17,369
Female tissues 81 | 17,400
Liver and Pancreas 80 | 16,750
Blood and immune system 79 | 16,909
Respiratory system 78 | 16,393
Skin and soft tissues 78 | 17,230
Urinary Tract 78 | 16,678
Nervous System 76 | 16,725
Cardiovascular System 73 | 15,192

Target Family

Non-IDG 44 | 12,091
Enzyme 19 | 4,145
Epigenetic 5 | 242
Transcription Factor 5 | 1,400
Kinase 3 | 634
Ion Channel 2 | 344
Transporter 2 | 473
GPCR 1 | 408
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ETS domain-containing protein Elk-4 ELK4 Tbio Transcription Factor -1.07328 11.4 100
ER membrane protein complex subunit 10 EMC10 Tbio Non-IDG -1.41680 25.5 60
N-acetyltransferase ESCO1 ESCO1 Tbio Enzyme -1.65145 44.6 49
Putative ADP-ribosylation factor-like protein 5C ARL5C Tdark Enzyme 0.00000 1.00 39
Ras-related protein Rab-36 RAB36 Tdark Enzyme -0.51688 3.97 90
Dysbindin domain-containing protein 2 DBNDD2 Tdark Non-IDG 0.23 0.66 28
Putative sodium-coupled neutral amino acid transporter 10 SLC38A10 Tdark Transporter -0.27712 1.71 25
Seizure 6-like protein SEZ6L Tbio Non-IDG -0.86297 6.90 49
Centromere protein J CENPJ Tbio Non-IDG -1.79588 59.0 102
Latent-transforming growth factor beta-binding protein 1 LTBP1 Tbio Non-IDG -1.97590 101.5 128