Development Level

Tbio 56 | 10,625
Tdark 14 | 7,003
Tchem 6 | 1,890
Tclin 3 | 602

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

decreased circulating serum al... 79 | 79
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 43 | 8,484
osteosarcoma 33 | 7,933
psoriasis 33 | 6,685
medulloblastoma, large-cell 31 | 6,234
atypical teratoid / rhabdoid tumor 28 | 4,369
glioblastoma 26 | 5,572
lung cancer 24 | 4,466
malignant mesothelioma 21 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
pilocytic astrocytoma 18 | 3,086
primitive neuroectodermal tumor 18 | 3,031
subependymal giant cell astrocytoma 18 | 2,287
Breast cancer 17 | 3,094
ependymoma 17 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,988
oligodendroglioma 17 | 2,849
Carcinoma 16 | 2,147
lung carcinoma 15 | 2,844
pancreatic cancer 15 | 2,300
primary pancreatic ductal adenocarcinoma 15 | 1,271
interstitial cystitis 14 | 2,299
invasive ductal carcinoma 14 | 2,950
Pick disease 13 | 1,893
astrocytoma 13 | 1,493
medulloblastoma 12 | 1,524
pediatric high grade glioma 12 | 2,712
group 3 medulloblastoma 11 | 2,254
lung adenocarcinoma 11 | 2,713
breast carcinoma 10 | 1,614
juvenile dermatomyositis 10 | 1,189
adult high grade glioma 9 | 2,148
posterior fossa group B ependymoma 9 | 1,530
Cancer 8 | 2,346
adrenocortical carcinoma 8 | 1,427
group 4 medulloblastoma 8 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
pituitary cancer 8 | 1,972
progressive supranuclear palsy 8 | 674
Alzheimer's disease 7 | 644
Down syndrome 7 | 548
Rheumatoid Arthritis 7 | 1,160
astrocytic glioma 7 | 2,241
atypical teratoid/rhabdoid tumor 7 | 1,095
colon cancer 7 | 1,475
cutaneous lupus erythematosus 7 | 1,056
ductal carcinoma in situ 7 | 1,745
esophageal adenocarcinoma 7 | 737
sonic hedgehog group medulloblastoma 7 | 1,482
spina bifida 7 | 1,064
tuberculosis 7 | 1,557
Intellectual disability 6 | 573
acute quadriplegic myopathy 6 | 1,157
non primary Sjogren syndrome sicca 6 | 840
ulcerative colitis 6 | 2,087
fibroadenoma 5 | 557
gastric carcinoma 5 | 832
non-small cell lung cancer 5 | 2,798
posterior fossa group A ependymoma 5 | 1,511
primary Sjogren syndrome 5 | 789
Atopic dermatitis 4 | 944
Duchenne muscular dystrophy 4 | 602
Neurodegenerative disease 4 | 383
Waldenstrons macroglobulinemia 4 | 765
acute myeloid leukemia 4 | 780
aldosterone-producing adenoma 4 | 664
diabetes mellitus 4 | 1,663
inflammatory breast cancer 4 | 404
interstitial lung disease 4 | 291
Autistic Disorder 3 | 320
Kidney disease 3 | 396
Obesity 3 | 616
Parkinson's disease 3 | 364
Polycystic Ovary Syndrome 3 | 332
active Crohn's disease 3 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
chronic rhinosinusitis 3 | 512
cystic fibrosis 3 | 1,665
glioblastoma multiforme 3 | 347
nasopharyngeal carcinoma 3 | 1,056
nephrosclerosis 3 | 329
non-small cell lung carcinoma 3 | 413
tuberculosis and treatment for 6 months 3 | 686
Amyotrophic Lateral Sclerosis 2 | 431
Becker muscular dystrophy 2 | 187
Dementia 2 | 129
Hypertension 2 | 287
IGA Glomerulonephritis 2 | 454
Liver carcinoma 2 | 217
Metabolic syndrome X 2 | 155
Microcephaly 2 | 149
Mucopolysaccharidosis 2 | 24
Multiple Sclerosis 2 | 498
Multiple myeloma 2 | 1,327
Schizophrenia 2 | 501
chronic lymphosyte leukemia 2 | 232
hereditary spastic paraplegia 2 | 313
mucosa-associated lymphoid tissue lymphoma 2 | 480
pancreatic carcinoma 2 | 567
tuberculosis and treatment for 3 months 2 | 327

Tissue

Digestive Tract 79 | 18,473
Respiratory system 79 | 17,484
Blood and immune system 78 | 17,995
Cardiovascular System 78 | 17,958
Endocrine System 78 | 18,512
Female tissues 78 | 18,647
Liver and Pancreas 78 | 18,136
Male tissues 78 | 17,969
Nervous System 78 | 18,561
Skin and soft tissues 78 | 18,115
Urinary Tract 78 | 18,444

Target Family

Non-IDG 42 | 11,971
Enzyme 18 | 4,146
Epigenetic 5 | 242
Transcription Factor 5 | 1,400
Kinase 4 | 634
Transporter 3 | 473
Ion Channel 1 | 341
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788