Development Level

Tbio 73 | 10,625
Tdark 30 | 7,003
Tchem 16 | 1,890
Tclin 2 | 602

Collection

Eligible Kinase Proteins 2 | 134
Eligible Ion Channel Proteins 1 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

decreased circulating glucose ... 121 | 121
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

osteosarcoma 65 | 7,933
psoriasis 55 | 6,685
ovarian cancer 54 | 8,484
glioblastoma 42 | 5,572
medulloblastoma, large-cell 42 | 6,234
atypical teratoid / rhabdoid tumor 29 | 4,369
lung cancer 29 | 4,466
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,289
non-small cell lung cancer 26 | 2,798
oligodendroglioma 25 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,988
pediatric high grade glioma 24 | 2,712
malignant mesothelioma 23 | 3,162
lung adenocarcinoma 21 | 2,713
lung carcinoma 20 | 2,844
pilocytic astrocytoma 20 | 3,086
Breast cancer 18 | 3,094
invasive ductal carcinoma 18 | 2,950
primitive neuroectodermal tumor 18 | 3,031
astrocytic glioma 17 | 2,241
group 3 medulloblastoma 17 | 2,254
Pick disease 16 | 1,893
ependymoma 16 | 2,514
Cancer 15 | 2,346
Carcinoma 15 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
pituitary cancer 14 | 1,972
subependymal giant cell astrocytoma 14 | 2,287
ulcerative colitis 14 | 2,087
esophageal adenocarcinoma 13 | 737
interstitial cystitis 13 | 2,299
Rheumatoid Arthritis 12 | 1,160
adrenocortical carcinoma 12 | 1,427
adult high grade glioma 12 | 2,148
astrocytoma 12 | 1,493
colon cancer 12 | 1,475
pancreatic cancer 12 | 2,300
posterior fossa group B ependymoma 12 | 1,530
tuberculosis 12 | 1,557
medulloblastoma 11 | 1,524
Alzheimer's disease 10 | 644
ductal carcinoma in situ 10 | 1,745
group 4 medulloblastoma 10 | 1,875
posterior fossa group A ependymoma 10 | 1,511
spina bifida 10 | 1,064
juvenile dermatomyositis 9 | 1,189
sonic hedgehog group medulloblastoma 9 | 1,482
Neurodegenerative disease 8 | 383
active Crohn's disease 8 | 918
acute quadriplegic myopathy 8 | 1,157
nasopharyngeal carcinoma 8 | 1,056
Atopic dermatitis 7 | 944
atypical teratoid/rhabdoid tumor 7 | 1,095
breast carcinoma 7 | 1,614
cutaneous lupus erythematosus 7 | 1,056
cystic fibrosis 7 | 1,665
gastric carcinoma 6 | 832
nephrosclerosis 6 | 329
primary pancreatic ductal adenocarcinoma 6 | 1,271
Amyotrophic Lateral Sclerosis 5 | 431
Intellectual disability 5 | 573
Multiple Sclerosis 5 | 498
active ulcerative colitis 5 | 477
aldosterone-producing adenoma 5 | 664
diabetes mellitus 5 | 1,663
hereditary spastic paraplegia 5 | 313
non primary Sjogren syndrome sicca 5 | 840
Cerebrovascular disease 4 | 231
Down syndrome 4 | 548
Duchenne muscular dystrophy 4 | 602
Endometriosis 4 | 535
IGA Glomerulonephritis 4 | 454
Lung Neoplasms 4 | 171
Neuropathy 4 | 210
dermatomyositis 4 | 933
head and neck cancer and chronic obstructive pulmonary disease 4 | 237
hepatocellular carcinoma 4 | 532
non diabetic and post-ischemic heart failure 4 | 200
non-small cell lung carcinoma 4 | 413
primary Sjogren syndrome 4 | 789
progressive supranuclear palsy 4 | 674
tuberculosis and treatment for 6 months 4 | 686
Anemia 3 | 252
Asthma 3 | 349
Celiac disease 3 | 112
Chronic obstructive pulmonary disease 3 | 146
Heart disease 3 | 279
Microcephaly 3 | 149
Multiple myeloma 3 | 1,327
Paraplegia 3 | 71
Spontaneous abortion 3 | 108
acute myeloid leukemia 3 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
gastric cancer 3 | 430
pancreatic carcinoma 3 | 567
Juvenile arthritis 2 | 124
Waldenstrons macroglobulinemia 2 | 765
inflammatory breast cancer 2 | 404
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 121 | 17,995
Cardiovascular System 121 | 17,958
Digestive Tract 121 | 18,473
Endocrine System 121 | 18,512
Female tissues 121 | 18,647
Nervous System 121 | 18,561
Skin and soft tissues 121 | 18,115
Urinary Tract 121 | 18,444
Liver and Pancreas 120 | 18,136
Male tissues 120 | 17,969
Respiratory system 119 | 17,484

Target Family

Non-IDG 69 | 11,971
Enzyme 30 | 4,146
Epigenetic 6 | 242
Transcription Factor 6 | 1,400
Kinase 4 | 634
GPCR 3 | 406
Transporter 2 | 473
Ion Channel 1 | 341

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Hyaluronidase-3 HYAL3 Tbio Enzyme -0.90097 7.70 99
NAC-alpha domain-containing protein 1 NACAD Tbio Non-IDG -0.89395 7.61 52
Vitamin D-binding protein GC Tchem Non-IDG -3.02965 1072.9 365
Complement C1q subcomponent subunit A C1QA Tbio Non-IDG -1.71898 50.3 208
Polypeptide N-acetylgalactosaminyltransferase 18 GALNT18 Tdark Enzyme -0.28065 3.03 33
Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 Tchem Ion Channel -1.00872 12.4 65
39S ribosomal protein L51, mitochondrial MRPL51 Tdark Non-IDG -0.21560 1.59 76
Neurocalcin-delta NCALD Tbio Non-IDG -1.29236 20.2 87
Serine/threonine-protein kinase Nek11 NEK11 Tbio Kinase -0.65413 5.37 127