Development Level

Tbio 79 | 11,178
Tchem 22 | 1,885
Tdark 22 | 6,569
Tclin 3 | 612

Collection

Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

decreased circulating glucose ... 126 | 126
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 82 | 11,192
osteosarcoma 65 | 7,766
psoriasis 57 | 6,514
ovarian cancer 51 | 8,297
glioblastoma 46 | 5,635
medulloblastoma, large-cell 46 | 6,086
atypical teratoid / rhabdoid tumor 33 | 4,971
lung cancer 32 | 4,607
ependymoma 31 | 4,559
group 3 medulloblastoma 31 | 4,002
adult high grade glioma 29 | 3,701
oligodendroglioma 28 | 2,768
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,872
Breast cancer 25 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,204
malignant mesothelioma 25 | 3,135
non-small cell lung cancer 25 | 2,799
Kidney cancer 24 | 2,548
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,902
astrocytic glioma 23 | 2,530
Astrocytoma, Pilocytic 22 | 3,006
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,911
Pick disease 18 | 1,856
invasive ductal carcinoma 18 | 2,867
lung carcinoma 18 | 2,755
Cancer 17 | 2,388
lung adenocarcinoma 17 | 2,627
primitive neuroectodermal tumor 16 | 2,957
pituitary cancer 15 | 1,915
tuberculosis 15 | 1,963
subependymal giant cell astrocytoma 14 | 2,230
Rheumatoid arthritis 13 | 1,156
acute quadriplegic myopathy 13 | 1,133
Autosomal recessive predisposition 12 | 1,407
esophageal adenocarcinoma 12 | 696
interstitial cystitis 12 | 2,237
ulcerative colitis 12 | 1,765
adrenocortical carcinoma 11 | 1,385
group 4 medulloblastoma 11 | 1,806
Schizophrenia 10 | 1,136
colon cancer 10 | 1,428
juvenile dermatomyositis 10 | 1,147
pancreatic cancer 10 | 2,322
pediatric high grade glioma 10 | 1,035
Liver Cirrhosis, Experimental 9 | 733
Neurodegenerative disease 9 | 402
active Crohn's disease 9 | 882
astrocytoma 9 | 1,113
diabetes mellitus 9 | 1,683
Alzheimer's disease 8 | 640
Atopic dermatitis 8 | 915
Intellectual disability 8 | 998
Seizures 8 | 584
ductal carcinoma in situ 8 | 1,686
non primary Sjogren syndrome sicca 8 | 861
spina bifida 8 | 1,053
Dull intelligence 7 | 634
Epilepsy 7 | 775
Low intelligence 7 | 634
Mental Retardation 7 | 634
Mental deficiency 7 | 634
Poor school performance 7 | 634
gastric carcinoma 7 | 781
nasopharyngeal carcinoma 7 | 1,024
progressive supranuclear palsy 7 | 656
Cleft Palate 6 | 265
Down syndrome 6 | 480
Duchenne muscular dystrophy 6 | 587
Endometriosis 6 | 521
Multiple Sclerosis 6 | 527
Obesity 6 | 655
Short stature 6 | 514
aldosterone-producing adenoma 6 | 646
breast carcinoma 6 | 1,589
cutaneous lupus erythematosus 6 | 1,016
hereditary spastic paraplegia 6 | 313
nephrosclerosis 6 | 314
posterior fossa group A ependymoma 6 | 456
Amyotrophic lateral sclerosis 5 | 437
Bipolar Disorder 5 | 646
Cognitive delay 5 | 596
Global developmental delay 5 | 596
Mental and motor retardation 5 | 596
Muscle hypotonia 5 | 562
Prostatic Neoplasms 5 | 472
Sensorineural Hearing Loss (disorder) 5 | 281
Uranostaphyloschisis 5 | 162
active ulcerative colitis 5 | 736
cystic fibrosis 5 | 1,629
dermatomyositis 5 | 941
posterior fossa group B ependymoma 5 | 406
Arthritis, Rheumatoid 4 | 169
Cerebrovascular disease 4 | 223
Depressive disorder 4 | 401
Liver cancer 4 | 589
Multiple myeloma 4 | 1,296
Neuropathy 4 | 254
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 492
fibroadenoma 4 | 538
primary pancreatic ductal adenocarcinoma 4 | 1,071

Tissue

Endocrine System 126 | 18,159
Digestive Tract 123 | 17,369
Skin and soft tissues 123 | 17,230
Female tissues 121 | 17,400
Male tissues 121 | 17,142
Liver and Pancreas 120 | 16,750
Urinary Tract 120 | 16,678
Blood and immune system 119 | 16,909
Nervous System 117 | 16,725
Respiratory system 117 | 16,393
Cardiovascular System 109 | 15,192

Target Family

Non-IDG 67 | 12,091
Enzyme 31 | 4,145
Transcription Factor 9 | 1,400
Epigenetic 6 | 242
Kinase 5 | 634
Transporter 4 | 473
Ion Channel 2 | 344
GPCR 1 | 408
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphatidylinositol-glycan-specific phospholipase D GPLD1 Tbio Enzyme -2.08209 126.8 222
Alkaline ceramidase 1 ACER1 Tbio Enzyme -0.89946 7.07 114
Mesoderm induction early response protein 1 MIER1 Tbio Non-IDG -2.21641 165.6 93
ATP-dependent Clp protease proteolytic subunit, mitochondrial CLPP Tbio Enzyme -2.67803 471.0 188
Serine/threonine-protein kinase Nek7 NEK7 Tchem Kinase -1.31475 20.8 261
Serine/threonine-protein phosphatase PGAM5, mitochondrial PGAM5 Tbio Enzyme -1.40119 21.5 27
T-box brain protein 1 TBR1 Tbio Transcription Factor -1.86637 67.2 146
SH3 domain and tetratricopeptide repeat-containing protein 2 SH3TC2 Tbio Non-IDG -2.27646 182.7 36
Tubulin--tyrosine ligase-like protein 12 TTLL12 Tbio Enzyme -0.67312 5.81 112
Nuclear export mediator factor NEMF NEMF Tbio Non-IDG -0.93499 7.71 157