Development Level

Tbio 83 | 11,445
Tdark 22 | 6,588
Tchem 18 | 1,598
Tclin 3 | 613

Collection

RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

decreased circulating glucose ... 126 | 126
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 83 | 11,493
osteosarcoma 68 | 7,950
psoriasis 58 | 6,694
ovarian cancer 53 | 8,520
medulloblastoma, large-cell 47 | 6,241
glioblastoma 46 | 5,792
atypical teratoid / rhabdoid tumor 33 | 5,112
lung cancer 33 | 4,740
group 3 medulloblastoma 32 | 4,104
ependymoma 31 | 4,679
adult high grade glioma 29 | 3,801
oligodendroglioma 28 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,955
malignant mesothelioma 26 | 3,232
Breast cancer 25 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
non-small cell lung cancer 25 | 2,890
Kidney cancer 24 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
astrocytic glioma 23 | 2,597
Astrocytoma, Pilocytic 22 | 3,081
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
Pick disease 18 | 1,894
invasive ductal carcinoma 18 | 2,951
lung carcinoma 18 | 2,843
Cancer 17 | 2,499
lung adenocarcinoma 17 | 2,716
primitive neuroectodermal tumor 16 | 3,035
tuberculosis 16 | 2,010
pituitary cancer 15 | 1,972
acute quadriplegic myopathy 14 | 1,158
subependymal giant cell astrocytoma 14 | 2,287
Rheumatoid arthritis 13 | 1,191
Autosomal recessive predisposition 12 | 1,442
esophageal adenocarcinoma 12 | 737
interstitial cystitis 12 | 2,312
ulcerative colitis 12 | 1,819
adrenocortical carcinoma 11 | 1,428
group 4 medulloblastoma 11 | 1,855
Schizophrenia 10 | 1,160
colon cancer 10 | 1,478
juvenile dermatomyositis 10 | 1,187
pancreatic cancer 10 | 2,398
pediatric high grade glioma 10 | 1,064
Liver Cirrhosis, Experimental 9 | 769
Neurodegenerative disease 9 | 414
active Crohn's disease 9 | 922
astrocytoma 9 | 1,146
diabetes mellitus 9 | 1,728
Alzheimer's disease 8 | 658
Atopic dermatitis 8 | 952
Intellectual disability 8 | 1,016
Seizures 8 | 596
ductal carcinoma in situ 8 | 1,745
non primary Sjogren syndrome sicca 8 | 891
spina bifida 8 | 1,074
Dull intelligence 7 | 645
Epilepsy 7 | 792
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
gastric carcinoma 7 | 807
nasopharyngeal carcinoma 7 | 1,058
progressive supranuclear palsy 7 | 676
Cleft Palate 6 | 271
Down syndrome 6 | 499
Duchenne muscular dystrophy 6 | 601
Endometriosis 6 | 540
Multiple Sclerosis 6 | 540
Obesity 6 | 678
Short stature 6 | 531
aldosterone-producing adenoma 6 | 665
breast carcinoma 6 | 1,638
cutaneous lupus erythematosus 6 | 1,057
hereditary spastic paraplegia 6 | 318
nephrosclerosis 6 | 333
posterior fossa group A ependymoma 6 | 468
Amyotrophic lateral sclerosis 5 | 451
Bipolar Disorder 5 | 666
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Muscle hypotonia 5 | 571
Prostatic Neoplasms 5 | 495
Sensorineural Hearing Loss (disorder) 5 | 284
Uranostaphyloschisis 5 | 167
active ulcerative colitis 5 | 764
cystic fibrosis 5 | 1,696
dermatomyositis 5 | 966
posterior fossa group B ependymoma 5 | 416
Arthritis, Rheumatoid 4 | 174
Cerebrovascular disease 4 | 238
Depressive disorder 4 | 409
Liver cancer 4 | 604
Multiple myeloma 4 | 1,332
Neuropathy 4 | 261
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
fibroadenoma 4 | 559
primary pancreatic ductal adenocarcinoma 4 | 1,109

Tissue

Endocrine System 126 | 18,159
Digestive Tract 123 | 17,369
Skin and soft tissues 123 | 17,230
Female tissues 121 | 17,400
Male tissues 121 | 17,142
Liver and Pancreas 120 | 16,750
Urinary Tract 120 | 16,678
Blood and immune system 119 | 16,909
Nervous System 117 | 16,725
Respiratory system 117 | 16,393
Cardiovascular System 109 | 15,192

Target Family

Non-IDG 67 | 12,091
Enzyme 31 | 4,145
Transcription Factor 9 | 1,400
Epigenetic 6 | 242
Kinase 5 | 634
Transporter 4 | 473
Ion Channel 2 | 344
GPCR 1 | 408
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bromodomain and PHD finger-containing protein 3 BRPF3 Tchem Epigenetic -0.46982 2.70 64
Long-chain-fatty-acid--CoA ligase 5 ACSL5 Tbio Enzyme -1.98202 97.3 170
F-box only protein 11 FBXO11 Tbio Non-IDG -1.53905 34.1 258
Harmonin USH1C Tbio Non-IDG -2.10689 124.7 188
Transmembrane glycoprotein NMB GPNMB Tbio Non-IDG -2.05817 130.8 293
ER membrane protein complex subunit 10 EMC10 Tbio Non-IDG -1.41680 25.5 60
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Proton-coupled folate transporter SLC46A1 Tchem Transporter -2.23182 177.1 76
Importin-11 IPO11 Tbio Non-IDG -0.74763 5.44 154
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376