Development Level

Tbio 28 | 11,445
Tdark 5 | 6,588
Tchem 3 | 1,598

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

decreased circulating calcium ... 36 | 36
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 24 | 11,493
osteosarcoma 24 | 7,950
psoriasis 19 | 6,694
ovarian cancer 18 | 8,520
ependymoma 16 | 4,679
glioblastoma 16 | 5,792
Astrocytoma, Pilocytic 15 | 3,081
atypical teratoid / rhabdoid tumor 15 | 5,112
medulloblastoma, large-cell 15 | 6,241
adult high grade glioma 13 | 3,801
Breast cancer 12 | 3,578
malignant mesothelioma 12 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
invasive ductal carcinoma 10 | 2,951
non-small cell lung cancer 10 | 2,890
oligodendroglioma 10 | 2,850
astrocytic glioma 9 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
lung cancer 9 | 4,740
primitive neuroectodermal tumor 9 | 3,035
Kidney cancer 8 | 2,613
Pick disease 8 | 1,894
group 3 medulloblastoma 8 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
Cancer 7 | 2,499
cystic fibrosis 7 | 1,696
lung carcinoma 7 | 2,843
ductal carcinoma in situ 6 | 1,745
group 4 medulloblastoma 6 | 1,855
pituitary cancer 6 | 1,972
tuberculosis 6 | 2,010
ulcerative colitis 6 | 1,819
adrenocortical carcinoma 5 | 1,428
colon cancer 5 | 1,478
pancreatic cancer 5 | 2,398
Autosomal recessive predisposition 4 | 1,442
Cataract 4 | 297
Hypophosphatemia 4 | 40
Obesity 4 | 678
Osteomalacia 4 | 35
Parkinson's disease 4 | 392
Rickets 4 | 49
active ulcerative colitis 4 | 764
astrocytoma 4 | 1,146
breast carcinoma 4 | 1,638
interstitial cystitis 4 | 2,312
non primary Sjogren syndrome sicca 4 | 891
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Atopic dermatitis 3 | 952
Cerebellar Ataxia 3 | 304
Epilepsy 3 | 792
Hyperparathyroidism 3 | 48
Hyperphosphatemia 3 | 32
Hypertension 3 | 396
Multiple myeloma 3 | 1,332
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
cutaneous lupus erythematosus 3 | 1,057
diabetes mellitus 3 | 1,728
gastric carcinoma 3 | 807
lung adenocarcinoma 3 | 2,716
medulloblastoma 3 | 720
nasopharyngeal carcinoma 3 | 1,058
progressive supranuclear palsy 3 | 676
Adenoma 2 | 167
Alkaline phosphatase serum increased 2 | 29
Alopecia 2 | 115
Amyotrophic lateral sclerosis 2 | 451
Barrett's esophagus 2 | 182
Bone pain 2 | 42
Colorectal Neoplasms 2 | 243
Coronary artery disease 2 | 268
Endometriosis 2 | 540
Frontal bossing 2 | 157
Genu varum 2 | 29
Glaucoma 2 | 239
Hypercalcemia 2 | 59
Liver disease 2 | 237
Melanoma 2 | 711
Multiple Sclerosis 2 | 540
Muscle Spasticity 2 | 195
Nephrocalcinosis 2 | 35
Peripheral Neuropathy 2 | 134
Personality change 2 | 23
Polycystic ovary syndrome 2 | 360
Progressive disorder 2 | 142
Psychotic Disorders 2 | 151
Renal Cell Carcinoma 2 | 214
Retinal Degeneration 2 | 106
Schizophrenia 2 | 1,160
Skin cancer 2 | 469
Tremor 2 | 113
Waldenstrons macroglobulinemia 2 | 765
acute myeloid leukemia 2 | 783
dermatomyositis 2 | 966
esophageal adenocarcinoma 2 | 737
juvenile dermatomyositis 2 | 1,187
pediatric high grade glioma 2 | 1,064
spina bifida 2 | 1,074
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Endocrine System 36 | 18,159
Male tissues 35 | 17,142
Female tissues 34 | 17,400
Liver and Pancreas 34 | 16,750
Digestive Tract 33 | 17,369
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678
Blood and immune system 32 | 16,909
Nervous System 32 | 16,725
Respiratory system 32 | 16,393
Cardiovascular System 29 | 15,192

Target Family

Non-IDG 15 | 12,091
Enzyme 13 | 4,145
Transcription Factor 3 | 1,400
Transporter 3 | 473
Ion Channel 1 | 344
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative ADP-ribosylation factor-like protein 5C ARL5C Tdark Enzyme 0.00000 1.00 39
Vacuolar protein sorting-associated protein 13A VPS13A Tbio Non-IDG -2.19966 172.3 22
Putative sodium-coupled neutral amino acid transporter 10 SLC38A10 Tdark Transporter -0.27712 1.71 25
Centromere protein J CENPJ Tbio Non-IDG -1.79588 59.0 102
Transcription factor GATA-5 GATA5 Tbio Transcription Factor -1.95925 86.1 183
TOX high mobility group box family member 3 TOX3 Tbio Transcription Factor -1.64481 43.3 156
Cytochrome b561 CYB561 Tbio Non-IDG -1.41422 21.1 62
Ribose-5-phosphate isomerase RPIA Tbio Enzyme -2.88100 771.5 118
Extracellular serine/threonine protein kinase FAM20C FAM20C Tbio Enzyme -2.32591 210.3 90
Dual specificity protein kinase CLK1 CLK1 Tchem Kinase -1.93720 87.9 156