Development Level

Tbio 31 | 11,445
Tdark 8 | 6,588
Tchem 4 | 1,598
Tclin 3 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

decreased circulating alkaline... 46 | 46
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 35 | 11,493
osteosarcoma 27 | 7,950
ovarian cancer 24 | 8,520
psoriasis 21 | 6,694
medulloblastoma, large-cell 20 | 6,241
atypical teratoid / rhabdoid tumor 17 | 5,112
glioblastoma 17 | 5,792
Kidney cancer 14 | 2,613
adult high grade glioma 14 | 3,801
ependymoma 14 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
primitive neuroectodermal tumor 11 | 3,035
Astrocytoma, Pilocytic 10 | 3,081
Schizophrenia 10 | 1,160
lung cancer 10 | 4,740
non-small cell lung cancer 10 | 2,890
Cancer 9 | 2,499
Pick disease 9 | 1,894
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
subependymal giant cell astrocytoma 9 | 2,287
Bipolar Disorder 8 | 666
group 3 medulloblastoma 8 | 4,104
invasive ductal carcinoma 8 | 2,951
oligodendroglioma 8 | 2,850
Epilepsy 7 | 792
astrocytic glioma 7 | 2,597
group 4 medulloblastoma 7 | 1,855
interstitial cystitis 7 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pituitary cancer 7 | 1,972
spina bifida 7 | 1,074
Breast cancer 6 | 3,578
breast carcinoma 6 | 1,638
ductal carcinoma in situ 6 | 1,745
tuberculosis 6 | 2,010
Autosomal recessive predisposition 5 | 1,442
Depressive disorder 5 | 409
Endometrial cancer 5 | 311
Intellectual disability 5 | 1,016
Mental Depression 5 | 333
adrenocortical carcinoma 5 | 1,428
colon cancer 5 | 1,478
lung adenocarcinoma 5 | 2,716
pancreatic cancer 5 | 2,398
Alzheimer's disease 4 | 658
Kidney disease 4 | 430
Liver cancer 4 | 604
Obesity 4 | 678
Parkinson's disease 4 | 392
Rheumatoid arthritis 4 | 1,191
Seizures 4 | 596
astrocytoma 4 | 1,146
diabetes mellitus 4 | 1,728
lung carcinoma 4 | 2,843
malignant mesothelioma 4 | 3,232
nasopharyngeal carcinoma 4 | 1,058
Acquired metabolic disease 3 | 336
Autistic Disorder 3 | 364
Constipation 3 | 181
Dementia 3 | 175
Disease Models, Animal 3 | 155
Infantile onset 3 | 238
Large intestine cancer 3 | 126
Mood Disorders 3 | 184
active Crohn's disease 3 | 922
acute quadriplegic myopathy 3 | 1,158
cystic fibrosis 3 | 1,696
medulloblastoma 3 | 720
pediatric high grade glioma 3 | 1,064
Alzheimer Disease 2 | 83
Amyotrophic lateral sclerosis 2 | 451
Atopic dermatitis 2 | 952
Autism spectrum disorder 2 | 101
Creatine phosphokinase serum increased 2 | 110
Down syndrome 2 | 499
Elevated creatine kinase 2 | 110
Endometriosis 2 | 540
Huntington's disease 2 | 76
Hyperreflexia 2 | 209
Infertility 2 | 188
Kidney Failure 2 | 111
Major Depressive Disorder 2 | 301
Male infertility 2 | 206
Motor neuron disease 2 | 49
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Polycystic ovary syndrome 2 | 360
Prostatic Neoplasms 2 | 495
Renal Insufficiency 2 | 90
Renal failure in adulthood 2 | 76
Status Epilepticus 2 | 98
Toxic encephalopathy 2 | 141
Unipolar Depression 2 | 250
Vascular disease 2 | 319
atypical teratoid/rhabdoid tumor 2 | 357
esophageal adenocarcinoma 2 | 737
fibroadenoma 2 | 559
juvenile dermatomyositis 2 | 1,187
primary pancreatic ductal adenocarcinoma 2 | 1,109

Tissue

Digestive Tract 45 | 17,369
Endocrine System 45 | 18,159
Female tissues 45 | 17,400
Urinary Tract 45 | 16,678
Blood and immune system 44 | 16,909
Male tissues 44 | 17,142
Skin and soft tissues 44 | 17,230
Cardiovascular System 43 | 15,192
Liver and Pancreas 43 | 16,750
Nervous System 43 | 16,725
Respiratory system 43 | 16,393

Target Family

Non-IDG 24 | 12,091
Enzyme 11 | 4,145
Transporter 3 | 473
Ion Channel 2 | 344
Kinase 2 | 634
Transcription Factor 2 | 1,400
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RNA binding protein fox-1 homolog 3 RBFOX3 Tbio Non-IDG -3.23341 1462.9 208
Neurexin-1 NRXN1 Tbio Non-IDG -1.88807 125.1 174
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295
Putative sodium-coupled neutral amino acid transporter 10 SLC38A10 Tdark Transporter -0.27712 1.71 25
Syntaxin-8 STX8 Tbio Non-IDG -2.59234 391.5 134
STAGA complex 65 subunit gamma SUPT7L Tdark Non-IDG -0.46246 2.75 76
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Somatostatin SST Tbio Non-IDG -4.14886 13572.0 397
BTB/POZ domain-containing protein KCTD15 KCTD15 Tbio Non-IDG -1.04860 11.7 176