Development Level

Tbio 87 | 10,625
Tchem 17 | 1,890
Tdark 15 | 7,003
Tclin 7 | 602

Collection

Eligible non-olfactory GPCR Proteins 4 | 143
Eligible Ion Channel Proteins 1 | 117

IMPC Term

decreased bone mineral density 126 | 126
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 65 | 8,484
osteosarcoma 60 | 7,933
psoriasis 59 | 6,685
glioblastoma 50 | 5,572
medulloblastoma, large-cell 50 | 6,234
atypical teratoid / rhabdoid tumor 42 | 4,369
lung cancer 37 | 4,466
primitive neuroectodermal tumor 34 | 3,031
Breast cancer 30 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,289
pilocytic astrocytoma 29 | 3,086
oligodendroglioma 27 | 2,849
pediatric high grade glioma 27 | 2,712
subependymal giant cell astrocytoma 25 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,988
invasive ductal carcinoma 23 | 2,950
Cancer 22 | 2,346
Carcinoma 21 | 2,147
lung adenocarcinoma 21 | 2,713
lung carcinoma 21 | 2,844
malignant mesothelioma 21 | 3,162
non-small cell lung cancer 21 | 2,798
ependymoma 20 | 2,514
posterior fossa group A ependymoma 20 | 1,511
Pick disease 19 | 1,893
astrocytoma 19 | 1,493
adult high grade glioma 17 | 2,148
astrocytic glioma 17 | 2,241
group 4 medulloblastoma 17 | 1,875
ulcerative colitis 17 | 2,087
pancreatic cancer 16 | 2,300
pituitary cancer 16 | 1,972
primary pancreatic ductal adenocarcinoma 16 | 1,271
spina bifida 16 | 1,064
breast carcinoma 15 | 1,614
ductal carcinoma in situ 15 | 1,745
sonic hedgehog group medulloblastoma 15 | 1,482
interstitial cystitis 14 | 2,299
medulloblastoma 14 | 1,524
acute myeloid leukemia 13 | 780
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
group 3 medulloblastoma 12 | 2,254
Obesity 11 | 616
acute quadriplegic myopathy 11 | 1,157
colon cancer 11 | 1,475
diabetes mellitus 11 | 1,663
Rheumatoid Arthritis 10 | 1,160
adrenocortical carcinoma 10 | 1,427
primary Sjogren syndrome 10 | 789
Atopic dermatitis 9 | 944
Multiple myeloma 9 | 1,327
aldosterone-producing adenoma 9 | 664
esophageal adenocarcinoma 9 | 737
juvenile dermatomyositis 9 | 1,189
nasopharyngeal carcinoma 9 | 1,056
Intellectual disability 8 | 573
cystic fibrosis 8 | 1,665
nephrosclerosis 8 | 329
tuberculosis 8 | 1,557
Down syndrome 7 | 548
cutaneous lupus erythematosus 7 | 1,056
dermatomyositis 7 | 933
posterior fossa group B ependymoma 7 | 1,530
tuberculosis and treatment for 6 months 7 | 686
Duchenne muscular dystrophy 6 | 602
active Crohn's disease 6 | 918
atypical teratoid/rhabdoid tumor 6 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
chronic rhinosinusitis 6 | 512
gastric carcinoma 6 | 832
non primary Sjogren syndrome sicca 6 | 840
Colorectal Neoplasms 5 | 217
Hypertension 5 | 287
Mammary Neoplasms 5 | 410
active ulcerative colitis 5 | 477
Acquired metabolic disease 4 | 267
Alzheimer's disease 4 | 644
Infertility 4 | 163
Multiple Sclerosis 4 | 498
Osteoporosis 4 | 257
Parkinson's disease 4 | 364
Polycystic Ovary Syndrome 4 | 332
Premature ovarian failure 4 | 64
Stomach Neoplasms 4 | 282
fibroadenoma 4 | 557
glioblastoma multiforme 4 | 347
interstitial lung disease 4 | 291
non diabetic and post-ischemic heart failure 4 | 200
progressive supranuclear palsy 4 | 674
urothelial carcinoma 4 | 318
Inflammatory Bowel Diseases 3 | 87
Kidney disease 3 | 396
Male infertility 3 | 170
Peripheral Neuropathy 3 | 303
Prostatic Neoplasms 3 | 471
Vascular disease 3 | 281
hepatocellular carcinoma 3 | 532
pancreatic carcinoma 3 | 567
type II diabetes mellitus and post-ischemic heart failure 3 | 89

Tissue

Digestive Tract 125 | 18,473
Nervous System 125 | 18,561
Endocrine System 124 | 18,512
Female tissues 124 | 18,647
Liver and Pancreas 124 | 18,136
Urinary Tract 124 | 18,444
Cardiovascular System 123 | 17,958
Skin and soft tissues 123 | 18,115
Blood and immune system 122 | 17,995
Male tissues 122 | 17,969
Respiratory system 122 | 17,484

Target Family

Non-IDG 61 | 11,971
Enzyme 35 | 4,146
Transcription Factor 7 | 1,400
GPCR 6 | 406
Transporter 6 | 473
Epigenetic 5 | 242
Ion Channel 3 | 341
Kinase 2 | 634
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
mRNA decay activator protein ZFP36 ZFP36 Tbio Non-IDG -2.38153 220.3 0
Sodium/hydrogen exchanger 4 SLC9A4 Tdark Transporter -1.25841 17.4 6
Sodium-dependent phosphate transporter 2 SLC20A2 Tbio Transporter -2.18737 165.3 97
F-box only protein 27 FBXO27 Tbio Non-IDG -0.17724 1.07 68
Cytochrome b5 domain-containing protein 1 CYB5D1 Tdark Non-IDG -0.09691 1.25 65
Neurocalcin-delta NCALD Tbio Non-IDG -1.29236 20.2 87
Adhesion G protein-coupled receptor F5 ADGRF5 Tbio GPCR -0.84160 8.64 151
Leptin receptor LEPR Tclin Non-IDG -2.98449 751.7 530
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.65191 464.3 66
Spermatogenesis-associated protein 22 SPATA22 Tdark Non-IDG -0.69062 3.03 31