Development Level

Tbio 85 | 11,178
Tdark 19 | 6,569
Tchem 16 | 1,885
Tclin 6 | 612

Collection

GPCR: IDG Consortium (Targets) 3 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

decreased bone mineral density 126 | 126
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 92 | 11,192
ovarian cancer 68 | 8,297
psoriasis 56 | 6,514
glioblastoma 48 | 5,635
osteosarcoma 48 | 7,766
medulloblastoma, large-cell 47 | 6,086
atypical teratoid / rhabdoid tumor 40 | 4,971
ependymoma 36 | 4,559
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,204
lung cancer 34 | 4,607
group 3 medulloblastoma 33 | 4,002
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,902
Breast cancer 28 | 3,469
primitive neuroectodermal tumor 27 | 2,957
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,872
Cancer 24 | 2,388
Astrocytoma, Pilocytic 23 | 3,006
malignant mesothelioma 23 | 3,135
adult high grade glioma 21 | 3,701
astrocytic glioma 21 | 2,530
invasive ductal carcinoma 21 | 2,867
Kidney cancer 20 | 2,548
subependymal giant cell astrocytoma 20 | 2,230
non-small cell lung cancer 19 | 2,799
pituitary cancer 19 | 1,915
Autosomal recessive predisposition 18 | 1,407
Rheumatoid arthritis 18 | 1,156
oligodendroglioma 18 | 2,768
lung carcinoma 17 | 2,755
Pick disease 16 | 1,856
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,911
group 4 medulloblastoma 15 | 1,806
lung adenocarcinoma 15 | 2,627
pediatric high grade glioma 15 | 1,035
Intellectual disability 14 | 998
breast carcinoma 14 | 1,589
tuberculosis 14 | 1,963
ulcerative colitis 14 | 1,765
Obesity 13 | 655
spina bifida 13 | 1,053
Multiple myeloma 11 | 1,296
colon cancer 11 | 1,428
dermatomyositis 11 | 941
ductal carcinoma in situ 11 | 1,686
interstitial cystitis 11 | 2,237
pancreatic cancer 11 | 2,322
Short stature 10 | 514
acute myeloid leukemia 10 | 760
acute quadriplegic myopathy 10 | 1,133
diabetes mellitus 10 | 1,683
juvenile dermatomyositis 10 | 1,147
Muscle hypotonia 9 | 562
active ulcerative colitis 9 | 736
adrenocortical carcinoma 9 | 1,385
astrocytoma 9 | 1,113
primary pancreatic ductal adenocarcinoma 9 | 1,071
Dull intelligence 8 | 634
Epilepsy 8 | 775
Low intelligence 8 | 634
Mental Retardation 8 | 634
Mental deficiency 8 | 634
Poor school performance 8 | 634
active Crohn's disease 8 | 882
Atopic dermatitis 7 | 915
Down syndrome 7 | 480
Failure to gain weight 7 | 359
Osteoporosis 7 | 348
Pediatric failure to thrive 7 | 359
nephrosclerosis 7 | 314
primary Sjogren syndrome 7 | 710
Bipolar Disorder 6 | 646
Breast Neoplasms 6 | 423
Cognitive delay 6 | 596
Global developmental delay 6 | 596
Mammary Neoplasms 6 | 403
Mental and motor retardation 6 | 596
Multiple Sclerosis 6 | 527
Seizures 6 | 584
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 492
gastric carcinoma 6 | 781
nasopharyngeal carcinoma 6 | 1,024
non primary Sjogren syndrome sicca 6 | 861
tuberculosis and treatment for 6 months 6 | 399
urothelial carcinoma 6 | 303
Acquired metabolic disease 5 | 329
Hepatomegaly 5 | 280
Hypogonadism 5 | 169
Liver Cirrhosis, Experimental 5 | 733
Liver cancer 5 | 589
Liver carcinoma 5 | 229
Prostatic Neoplasms 5 | 472
chronic rhinosinusitis 5 | 505
cutaneous lupus erythematosus 5 | 1,016
esophageal adenocarcinoma 5 | 696
progressive supranuclear palsy 5 | 656
Curvature of spine 4 | 275
Endometriosis 4 | 521
Schizophrenia 4 | 1,136
fibroadenoma 4 | 538
hepatocellular carcinoma 4 | 536

Tissue

Endocrine System 124 | 18,159
Digestive Tract 122 | 17,369
Liver and Pancreas 121 | 16,750
Female tissues 120 | 17,400
Skin and soft tissues 120 | 17,230
Blood and immune system 119 | 16,909
Male tissues 119 | 17,142
Nervous System 118 | 16,725
Respiratory system 118 | 16,393
Urinary Tract 117 | 16,678
Cardiovascular System 111 | 15,192

Target Family

Non-IDG 51 | 12,091
Enzyme 44 | 4,145
Transcription Factor 10 | 1,400
GPCR 6 | 408
Transporter 6 | 473
Epigenetic 5 | 242
Kinase 2 | 634
Ion Channel 1 | 344
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase 2A KMT2A Tchem Epigenetic -2.88228 736.0 334
ATP-dependent Clp protease proteolytic subunit, mitochondrial CLPP Tbio Enzyme -2.67803 471.0 188
Probable G-protein coupled receptor 152 GPR152 Tbio GPCR -1.60692 41.8 107
Serine dehydratase-like SDSL Tbio Enzyme -2.81127 638.6 190
Ras GTPase-activating-like protein IQGAP1 IQGAP1 Tbio Enzyme -2.27732 224.8 291
Activity-dependent neuroprotector homeobox protein 2 ADNP2 Tdark Non-IDG -0.53148 2.71 58
DNA repair-scaffolding protein SPIDR Tbio Non-IDG -0.75333 5.57 24
Colorectal cancer-associated protein 2 COLCA2 Tdark Non-IDG -0.53285 3.32 0
Ubiquitin-protein ligase E3C UBE3C Tbio Enzyme -1.12526 14.1 101
Steroid 17-alpha-hydroxylase/17,20 lyase CYP17A1 Tclin Enzyme -3.09734 1226.2 369