Development Level

Tbio 107 | 11,651
Tdark 18 | 6,593
Tchem 15 | 1,388
Tclin 11 | 612

Collection

RFA-RM-18-021 3 | 328
GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

decreased bone mineral content 151 | 151
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 103 | 11,493
ovarian cancer 84 | 8,520
osteosarcoma 71 | 7,950
glioblastoma 69 | 5,792
psoriasis 59 | 6,694
medulloblastoma, large-cell 58 | 6,241
atypical teratoid / rhabdoid tumor 55 | 5,112
ependymoma 52 | 4,679
group 3 medulloblastoma 42 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,291
adult high grade glioma 39 | 3,801
Breast cancer 34 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
lung cancer 32 | 4,740
primitive neuroectodermal tumor 32 | 3,035
Astrocytoma, Pilocytic 31 | 3,081
malignant mesothelioma 30 | 3,232
Pick disease 29 | 1,894
astrocytic glioma 27 | 2,597
oligodendroglioma 27 | 2,850
subependymal giant cell astrocytoma 27 | 2,287
Kidney cancer 26 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,989
invasive ductal carcinoma 26 | 2,951
non-small cell lung cancer 26 | 2,890
Cancer 25 | 2,499
group 4 medulloblastoma 22 | 1,855
Autosomal recessive predisposition 21 | 1,442
pancreatic cancer 21 | 2,398
pituitary cancer 21 | 1,972
lung carcinoma 20 | 2,843
Rheumatoid arthritis 19 | 1,191
adrenocortical carcinoma 19 | 1,428
tuberculosis 18 | 2,010
interstitial cystitis 17 | 2,312
Intellectual disability 16 | 1,016
diabetes mellitus 15 | 1,728
ductal carcinoma in situ 15 | 1,745
lung adenocarcinoma 15 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
astrocytoma 14 | 1,146
breast carcinoma 14 | 1,638
juvenile dermatomyositis 14 | 1,187
ulcerative colitis 14 | 1,819
Obesity 13 | 678
Schizophrenia 13 | 1,160
colon cancer 13 | 1,478
pediatric high grade glioma 13 | 1,064
Multiple myeloma 12 | 1,332
primary pancreatic ductal adenocarcinoma 12 | 1,109
Epilepsy 11 | 792
Short stature 11 | 531
active Crohn's disease 11 | 922
cystic fibrosis 11 | 1,696
Atopic dermatitis 10 | 952
Down syndrome 10 | 499
Parkinson's disease 9 | 392
active ulcerative colitis 9 | 764
acute myeloid leukemia 9 | 783
acute quadriplegic myopathy 9 | 1,158
esophageal adenocarcinoma 9 | 737
Thrombocytopenia 8 | 197
cutaneous lupus erythematosus 8 | 1,057
progressive supranuclear palsy 8 | 676
spina bifida 8 | 1,074
Breast Neoplasms 7 | 445
Dull intelligence 7 | 645
Dysarthria 7 | 192
Endometriosis 7 | 540
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Osteoporosis 7 | 363
Poor school performance 7 | 645
Prostatic Neoplasms 7 | 495
dermatomyositis 7 | 966
Acquired metabolic disease 6 | 336
Anemia 6 | 365
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Hypogonadism 6 | 173
Infertility 6 | 188
Liver Cirrhosis, Experimental 6 | 769
Liver cancer 6 | 604
Mammary Neoplasms 6 | 425
Mental and motor retardation 6 | 608
Seizures 6 | 596
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
nasopharyngeal carcinoma 6 | 1,058
pancreatic carcinoma 6 | 562
primary Sjogren syndrome 6 | 735
Alzheimer's disease 5 | 658
Bipolar Disorder 5 | 666
Cerebellar Ataxia 5 | 304
Delayed bone age 5 | 136
Duchenne muscular dystrophy 5 | 601
Muscle hypotonia 5 | 571
aldosterone-producing adenoma 5 | 665
gastric carcinoma 5 | 807
sonic hedgehog group medulloblastoma 5 | 467

Tissue

Endocrine System 150 | 18,159
Digestive Tract 146 | 17,369
Female tissues 146 | 17,400
Male tissues 143 | 17,142
Blood and immune system 142 | 16,909
Liver and Pancreas 142 | 16,750
Nervous System 142 | 16,725
Skin and soft tissues 142 | 17,230
Urinary Tract 142 | 16,678
Respiratory system 139 | 16,393
Cardiovascular System 137 | 15,192

Target Family

Non-IDG 74 | 12,091
Enzyme 47 | 4,145
Transcription Factor 7 | 1,400
GPCR 6 | 408
Kinase 6 | 634
Transporter 6 | 473
Epigenetic 2 | 242
Ion Channel 1 | 344
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
DNA (cytosine-5)-methyltransferase 3A DNMT3A Tclin Epigenetic -2.91291 722.8 693
Endophilin-A1 SH3GL2 Tbio Non-IDG -1.79540 59.9 248
Transcriptional enhancer factor TEF-1 TEAD1 Tbio Transcription Factor -1.71108 45.2 164
HBS1-like protein HBS1L Tbio Non-IDG -2.55785 357.2 263
Protein Hook homolog 3 HOOK3 Tbio Non-IDG -1.22079 6.06 60
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform PPP2R2A Tchem Enzyme -1.32606 14.4 130
Rho-related BTB domain-containing protein 3 RHOBTB3 Tbio Non-IDG -0.85594 8.08 81
HIRA-interacting protein 3 HIRIP3 Tdark Non-IDG -0.20893 1.52 145