Development Level

Tbio 110 | 10,625
Tdark 20 | 7,003
Tchem 19 | 1,890
Tclin 8 | 602

Collection

Eligible non-olfactory GPCR Proteins 2 | 145
Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

decreased bone mineral content 157 | 157
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 84 | 8,492
osteosarcoma 76 | 7,933
glioblastoma 73 | 5,572
psoriasis 71 | 6,685
medulloblastoma, large-cell 63 | 6,234
atypical teratoid / rhabdoid tumor 60 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 45 | 3,289
pilocytic astrocytoma 41 | 3,086
Breast cancer 40 | 3,099
primitive neuroectodermal tumor 40 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,956
lung cancer 37 | 4,473
pediatric high grade glioma 36 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,988
Cancer 33 | 2,346
malignant mesothelioma 32 | 3,163
oligodendroglioma 32 | 2,849
non-small cell lung cancer 29 | 2,798
Pick disease 28 | 1,893
ependymoma 28 | 2,514
lung carcinoma 27 | 2,844
subependymal giant cell astrocytoma 27 | 2,287
invasive ductal carcinoma 25 | 2,950
adult high grade glioma 24 | 2,148
posterior fossa group A ependymoma 24 | 1,511
astrocytic glioma 23 | 2,241
astrocytoma 23 | 1,493
medulloblastoma 22 | 1,524
pancreatic cancer 22 | 2,300
group 4 medulloblastoma 21 | 1,875
Carcinoma 20 | 2,147
ulcerative colitis 20 | 2,087
lung adenocarcinoma 19 | 2,714
sonic hedgehog group medulloblastoma 19 | 1,482
ductal carcinoma in situ 18 | 1,745
interstitial cystitis 18 | 2,299
pituitary cancer 18 | 1,972
Rheumatoid Arthritis 17 | 1,171
adrenocortical carcinoma 17 | 1,427
group 3 medulloblastoma 17 | 2,254
tuberculosis 17 | 1,563
colon cancer 15 | 1,475
esophageal adenocarcinoma 15 | 737
breast carcinoma 14 | 1,614
primary pancreatic ductal adenocarcinoma 14 | 1,271
Atopic dermatitis 13 | 944
cystic fibrosis 13 | 1,670
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
posterior fossa group B ependymoma 13 | 1,530
Intellectual disability 12 | 573
Down syndrome 11 | 548
Multiple myeloma 11 | 1,328
Parkinson's disease 11 | 364
cutaneous lupus erythematosus 11 | 1,056
juvenile dermatomyositis 11 | 1,189
active Crohn's disease 10 | 918
acute myeloid leukemia 10 | 785
nasopharyngeal carcinoma 10 | 1,056
spina bifida 10 | 1,064
Obesity 9 | 616
dermatomyositis 9 | 967
primary Sjogren syndrome 9 | 789
Multiple Sclerosis 8 | 498
Neurodegenerative disease 8 | 383
acute quadriplegic myopathy 8 | 1,157
diabetes mellitus 8 | 1,663
pancreatic carcinoma 8 | 567
progressive supranuclear palsy 8 | 674
Acquired metabolic disease 7 | 267
Microcephaly 7 | 149
atypical teratoid/rhabdoid tumor 7 | 1,095
gastric carcinoma 7 | 832
Alzheimer's disease 6 | 644
Epilepsy 6 | 346
Prostatic Neoplasms 6 | 471
aldosterone-producing adenoma 6 | 664
non primary Sjogren syndrome sicca 6 | 840
Amyotrophic Lateral Sclerosis 5 | 432
Infertility 5 | 163
Vascular disease 5 | 281
glioblastoma multiforme 5 | 347
hereditary spastic paraplegia 5 | 313
tuberculosis and treatment for 6 months 5 | 686
Celiac disease 4 | 112
Duchenne muscular dystrophy 4 | 602
Endometriosis 4 | 535
Hypertension 4 | 293
Hypogonadism 4 | 70
Liver Cirrhosis 4 | 101
Mammary Neoplasms 4 | 410
Polycystic Ovary Syndrome 4 | 335
Renal Cell Carcinoma 4 | 199
Schizophrenia 4 | 503
active ulcerative colitis 4 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
fibroadenoma 4 | 557
hepatocellular carcinoma 4 | 550
interstitial lung disease 4 | 292
nephrosclerosis 4 | 329
urothelial carcinoma 4 | 318

Tissue

Digestive Tract 157 | 18,473
Female tissues 157 | 18,647
Nervous System 157 | 18,561
Urinary Tract 157 | 18,444
Cardiovascular System 156 | 17,958
Liver and Pancreas 156 | 18,136
Male tissues 156 | 17,969
Blood and immune system 155 | 17,995
Endocrine System 155 | 18,512
Respiratory system 154 | 17,484
Skin and soft tissues 154 | 18,115

Target Family

Non-IDG 84 | 11,969
Enzyme 39 | 4,146
Transcription Factor 9 | 1,400
GPCR 6 | 408
Kinase 6 | 634
Transporter 6 | 473
Epigenetic 4 | 242
TF/Epigenetic 2 | 38
Ion Channel 1 | 341

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363
Protein Hook homolog 3 HOOK3 Tbio Non-IDG -1.18684 0.00000 55
Synembryn-B RIC8B Tbio Non-IDG -1.63259 43.4 37
Protein FAM134C FAM134C Tdark Non-IDG 0.30 0.44 50
HBS1-like protein HBS1L Tbio Non-IDG -2.52098 316.2 144
E3 ubiquitin-protein ligase FANCL FANCL Tbio Enzyme -2.44869 275.2 115
E3 ubiquitin-protein ligase SMURF1 SMURF1 Tbio Enzyme -1.90072 75.1 274
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC Tbio Enzyme -2.71429 399.0 110
Ubiquitin-conjugating enzyme E2 J1 UBE2J1 Tbio Non-IDG -1.10231 11.9 148
Calsyntenin-3 CLSTN3 Tbio Non-IDG -0.79076 6.97 21