Development Level

Tbio 120 | 10,625
Tchem 26 | 1,890
Tdark 23 | 7,003
Tclin 5 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

decreased body weight 174 | 174
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 102 | 8,484
osteosarcoma 87 | 7,933
psoriasis 71 | 6,685
medulloblastoma, large-cell 68 | 6,234
glioblastoma 65 | 5,572
lung cancer 61 | 4,466
atypical teratoid / rhabdoid tumor 53 | 4,369
malignant mesothelioma 46 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,289
primitive neuroectodermal tumor 38 | 3,031
Breast cancer 37 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,956
ependymoma 32 | 2,514
pilocytic astrocytoma 32 | 3,086
pediatric high grade glioma 30 | 2,712
invasive ductal carcinoma 29 | 2,950
Cancer 28 | 2,346
Pick disease 28 | 1,893
subependymal giant cell astrocytoma 28 | 2,287
lung carcinoma 27 | 2,844
Carcinoma 26 | 2,147
non-small cell lung cancer 26 | 2,798
oligodendroglioma 26 | 2,849
lung adenocarcinoma 25 | 2,713
group 3 medulloblastoma 24 | 2,254
adult high grade glioma 23 | 2,148
astrocytic glioma 23 | 2,241
pancreatic cancer 23 | 2,300
interstitial cystitis 22 | 2,299
astrocytoma 20 | 1,493
colon cancer 20 | 1,475
group 4 medulloblastoma 20 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,795
ulcerative colitis 20 | 2,087
adrenocortical carcinoma 19 | 1,427
ductal carcinoma in situ 19 | 1,745
pituitary cancer 19 | 1,972
juvenile dermatomyositis 18 | 1,189
medulloblastoma 18 | 1,524
sonic hedgehog group medulloblastoma 18 | 1,482
spina bifida 18 | 1,064
cystic fibrosis 17 | 1,665
diabetes mellitus 17 | 1,663
posterior fossa group A ependymoma 17 | 1,511
posterior fossa group B ependymoma 17 | 1,530
Multiple myeloma 16 | 1,327
Rheumatoid Arthritis 16 | 1,160
atypical teratoid/rhabdoid tumor 15 | 1,095
primary pancreatic ductal adenocarcinoma 15 | 1,271
Down syndrome 14 | 548
acute quadriplegic myopathy 14 | 1,157
dermatomyositis 14 | 933
Alzheimer's disease 13 | 644
Atopic dermatitis 13 | 944
Intellectual disability 13 | 573
breast carcinoma 13 | 1,614
progressive supranuclear palsy 13 | 674
esophageal adenocarcinoma 12 | 737
gastric carcinoma 12 | 832
Waldenstrons macroglobulinemia 10 | 765
Obesity 9 | 616
cutaneous lupus erythematosus 9 | 1,056
non primary Sjogren syndrome sicca 9 | 840
tuberculosis 9 | 1,557
tuberculosis and treatment for 6 months 9 | 686
Microcephaly 8 | 149
active Crohn's disease 8 | 918
acute myeloid leukemia 8 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
chronic rhinosinusitis 8 | 512
fibroadenoma 8 | 557
nasopharyngeal carcinoma 8 | 1,056
Amyotrophic Lateral Sclerosis 7 | 431
Mammary Neoplasms 7 | 410
Osteoporosis 7 | 257
Polycystic Ovary Syndrome 7 | 332
active ulcerative colitis 7 | 477
aldosterone-producing adenoma 7 | 664
Acquired metabolic disease 6 | 267
Heart disease 6 | 279
Hypertension 6 | 287
Melanoma 6 | 261
Parkinson's disease 6 | 364
inflammatory breast cancer 6 | 404
pancreatic carcinoma 6 | 567
primary Sjogren syndrome 6 | 789
Bipolar Disorder 5 | 266
Colorectal Neoplasms 5 | 217
IGA Glomerulonephritis 5 | 454
Kidney disease 5 | 396
Schizophrenia 5 | 501
Chronic obstructive pulmonary disease 4 | 146
Duchenne muscular dystrophy 4 | 602
Endometriosis 4 | 535
Peripheral Neuropathy 4 | 303
gastric cancer 4 | 430
hepatocellular carcinoma 4 | 532
periodontitis 4 | 269
urothelial carcinoma 4 | 318

Tissue

Digestive Tract 173 | 18,473
Female tissues 173 | 18,647
Liver and Pancreas 173 | 18,136
Nervous System 173 | 18,561
Urinary Tract 172 | 18,444
Blood and immune system 171 | 17,995
Cardiovascular System 171 | 17,958
Endocrine System 171 | 18,512
Male tissues 171 | 17,969
Skin and soft tissues 171 | 18,115
Respiratory system 169 | 17,484

Target Family

Non-IDG 85 | 11,971
Enzyme 48 | 4,146
Epigenetic 9 | 242
Kinase 8 | 634
Transcription Factor 8 | 1,400
Ion Channel 6 | 341
GPCR 4 | 406
Transporter 4 | 473
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Protein THEMIS2 THEMIS2 Tbio Non-IDG -1.15987 17.5 42
Pleckstrin homology domain-containing family M member 2 PLEKHM2 Tbio Non-IDG -0.22831 2.68 56
Inositol polyphosphate 1-phosphatase INPP1 Tbio Enzyme -1.22269 17.2 73
Insulin-degrading enzyme IDE Tchem Enzyme -2.54789 384.2 283
Protein FAM107B FAM107B Tdark Non-IDG -0.03476 1.82 16
Ciliary neurotrophic factor receptor subunit alpha CNTFR Tbio Non-IDG -1.62134 35.4 184
Glycogen synthase kinase-3 alpha GSK3A Tclin Kinase -1.81647 52.3 722
Structural maintenance of chromosomes protein 3 SMC3 Tbio Non-IDG -2.05162 104.9 234
Dual specificity mitogen-activated protein kinase kinase 2 MAP2K2 Tclin Kinase -1.78634 57.0 688