Development Level

Tbio 123 | 11,651
Tchem 18 | 1,388
Tdark 14 | 6,593
Tclin 6 | 612

IMPC Phenotype

decreased body weight 161 | 161
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 134 | 11,493
ovarian cancer 92 | 8,520
osteosarcoma 81 | 7,950
psoriasis 66 | 6,694
medulloblastoma, large-cell 64 | 6,241
glioblastoma 60 | 5,792
atypical teratoid / rhabdoid tumor 58 | 5,112
lung cancer 56 | 4,740
group 3 medulloblastoma 51 | 4,104
ependymoma 48 | 4,679
malignant mesothelioma 42 | 3,232
Kidney cancer 40 | 2,613
Breast cancer 36 | 3,578
adult high grade glioma 36 | 3,801
primitive neuroectodermal tumor 35 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,291
Astrocytoma, Pilocytic 31 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,989
Cancer 28 | 2,499
invasive ductal carcinoma 28 | 2,951
Pick disease 26 | 1,894
oligodendroglioma 25 | 2,850
subependymal giant cell astrocytoma 25 | 2,287
Intellectual disability 23 | 1,016
pancreatic cancer 23 | 2,398
Autosomal recessive predisposition 22 | 1,442
astrocytic glioma 22 | 2,597
ductal carcinoma in situ 22 | 1,745
colon cancer 21 | 1,478
lung carcinoma 21 | 2,843
non-small cell lung cancer 21 | 2,890
interstitial cystitis 20 | 2,312
pituitary cancer 20 | 1,972
juvenile dermatomyositis 19 | 1,187
spina bifida 19 | 1,074
cystic fibrosis 18 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
acute quadriplegic myopathy 17 | 1,158
lung adenocarcinoma 17 | 2,716
ulcerative colitis 17 | 1,819
diabetes mellitus 16 | 1,728
Dull intelligence 15 | 645
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
astrocytoma 15 | 1,146
tuberculosis 15 | 2,010
Down syndrome 14 | 499
Schizophrenia 14 | 1,160
Short stature 14 | 531
adrenocortical carcinoma 14 | 1,428
dermatomyositis 14 | 966
group 4 medulloblastoma 14 | 1,855
Atopic dermatitis 13 | 952
Epilepsy 13 | 792
Rheumatoid arthritis 13 | 1,191
Bipolar Disorder 12 | 666
Cognitive delay 12 | 608
Depressive disorder 12 | 409
Global developmental delay 12 | 608
Mental and motor retardation 12 | 608
esophageal adenocarcinoma 12 | 737
non primary Sjogren syndrome sicca 12 | 891
primary pancreatic ductal adenocarcinoma 12 | 1,109
progressive supranuclear palsy 12 | 676
breast carcinoma 11 | 1,638
pediatric high grade glioma 11 | 1,064
Alzheimer's disease 10 | 658
Multiple myeloma 10 | 1,332
Muscle hypotonia 10 | 571
Seizures 10 | 596
Concave bridge of nose 9 | 195
Depressed nasal bridge 9 | 195
Depressed nasal root/bridge 9 | 195
Failure to gain weight 9 | 365
Liver Cirrhosis, Experimental 9 | 769
Melanoma 9 | 711
Pediatric failure to thrive 9 | 365
Waldenstrons macroglobulinemia 9 | 765
active ulcerative colitis 9 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
cutaneous lupus erythematosus 9 | 1,057
tuberculosis and treatment for 6 months 9 | 409
Cryptorchidism 8 | 296
Microcephaly 8 | 166
Obesity 8 | 678
Osteoporosis 8 | 363
acute myeloid leukemia 8 | 783
aldosterone-producing adenoma 8 | 665
fibroadenoma 8 | 559
gastric cancer 8 | 459
gastric carcinoma 8 | 807
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Nystagmus 7 | 317
chronic rhinosinusitis 7 | 512
nasopharyngeal carcinoma 7 | 1,058

Tissue

Endocrine System 159 | 18,159
Digestive Tract 158 | 17,369
Female tissues 158 | 17,400
Skin and soft tissues 157 | 17,230
Nervous System 155 | 16,725
Blood and immune system 154 | 16,909
Liver and Pancreas 154 | 16,750
Male tissues 154 | 17,142
Urinary Tract 153 | 16,678
Respiratory system 152 | 16,393
Cardiovascular System 145 | 15,192

Target Family

Non-IDG 81 | 12,091
Enzyme 43 | 4,145
Transcription Factor 9 | 1,400
Epigenetic 8 | 242
Kinase 6 | 634
Transporter 5 | 473
Ion Channel 4 | 344
GPCR 3 | 408
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
GDH/6PGL endoplasmic bifunctional protein H6PD Tbio Non-IDG -2.24806 169.7 207
Disks large homolog 2 DLG2 Tbio Non-IDG -1.75838 53.6 227
Nuclear-interacting partner of ALK ZC3HC1 Tbio Non-IDG -2.13812 136.0 171
Glycogen [starch] synthase, liver GYS2 Tbio Enzyme -1.61077 38.6 69
Protein argonaute-1 AGO1 Tbio Non-IDG -2.22336 158.4 203
A-kinase anchor protein 9 AKAP9 Tbio Enzyme -2.22554 169.7 142
E3 ubiquitin-protein ligase MARCH5 MARCH5 Tbio Epigenetic -1.47833 33.3 156
Short transient receptor potential channel 3 TRPC3 Tchem Ion Channel -2.46704 294.6 217
Reticulophagy regulator 3 RETREG3 Tdark Non-IDG 0.19 0.44 53