Development Level

Tbio 118 | 11,178
Tchem 23 | 1,885
Tdark 14 | 6,569
Tclin 6 | 612

IMPC Phenotype

decreased body weight 161 | 161
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 129 | 11,192
ovarian cancer 89 | 8,297
osteosarcoma 78 | 7,766
psoriasis 63 | 6,514
medulloblastoma, large-cell 61 | 6,086
glioblastoma 57 | 5,635
atypical teratoid / rhabdoid tumor 56 | 4,971
lung cancer 55 | 4,607
group 3 medulloblastoma 50 | 4,002
ependymoma 47 | 4,559
malignant mesothelioma 41 | 3,135
Kidney cancer 37 | 2,548
Breast cancer 35 | 3,469
adult high grade glioma 35 | 3,701
primitive neuroectodermal tumor 35 | 2,957
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,872
Astrocytoma, Pilocytic 30 | 3,006
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,204
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,902
Cancer 27 | 2,388
invasive ductal carcinoma 27 | 2,867
Pick disease 24 | 1,856
oligodendroglioma 24 | 2,768
subependymal giant cell astrocytoma 24 | 2,230
Intellectual disability 23 | 998
astrocytic glioma 22 | 2,530
pancreatic cancer 22 | 2,322
colon cancer 21 | 1,428
ductal carcinoma in situ 21 | 1,686
non-small cell lung cancer 21 | 2,799
Autosomal recessive predisposition 20 | 1,407
lung carcinoma 20 | 2,755
interstitial cystitis 19 | 2,237
pituitary cancer 19 | 1,915
spina bifida 19 | 1,053
juvenile dermatomyositis 17 | 1,147
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,911
ulcerative colitis 17 | 1,765
acute quadriplegic myopathy 16 | 1,133
cystic fibrosis 16 | 1,629
diabetes mellitus 16 | 1,683
lung adenocarcinoma 16 | 2,627
Dull intelligence 15 | 634
Low intelligence 15 | 634
Mental Retardation 15 | 634
Mental deficiency 15 | 634
Poor school performance 15 | 634
astrocytoma 15 | 1,113
tuberculosis 15 | 1,963
Schizophrenia 14 | 1,136
adrenocortical carcinoma 14 | 1,385
group 4 medulloblastoma 14 | 1,806
Atopic dermatitis 13 | 915
Down syndrome 13 | 480
Short stature 13 | 514
Bipolar Disorder 12 | 646
Cognitive delay 12 | 596
Depressive disorder 12 | 401
Epilepsy 12 | 775
Global developmental delay 12 | 596
Mental and motor retardation 12 | 596
Rheumatoid arthritis 12 | 1,156
dermatomyositis 12 | 941
primary pancreatic ductal adenocarcinoma 12 | 1,071
progressive supranuclear palsy 12 | 656
breast carcinoma 11 | 1,589
esophageal adenocarcinoma 11 | 696
non primary Sjogren syndrome sicca 11 | 861
pediatric high grade glioma 11 | 1,035
Alzheimer's disease 10 | 640
Muscle hypotonia 10 | 562
Seizures 10 | 584
Concave bridge of nose 9 | 191
Depressed nasal bridge 9 | 191
Depressed nasal root/bridge 9 | 191
Liver Cirrhosis, Experimental 9 | 733
Melanoma 9 | 689
Multiple myeloma 9 | 1,296
Waldenstrons macroglobulinemia 9 | 742
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 492
cutaneous lupus erythematosus 9 | 1,016
tuberculosis and treatment for 6 months 9 | 399
Cryptorchidism 8 | 287
Microcephaly 8 | 166
Obesity 8 | 655
Osteoporosis 8 | 348
active ulcerative colitis 8 | 736
aldosterone-producing adenoma 8 | 646
gastric carcinoma 8 | 781
Hypoplastic mandible condyle 7 | 273
Mandibular hypoplasia 7 | 273
Micrognathism 7 | 273
Nystagmus 7 | 309
Polycystic ovary syndrome 7 | 348
Strabismus 7 | 265
acute myeloid leukemia 7 | 760
chronic rhinosinusitis 7 | 505
fibroadenoma 7 | 538
gastric cancer 7 | 445
nasopharyngeal carcinoma 7 | 1,024

Tissue

Endocrine System 159 | 18,159
Digestive Tract 158 | 17,369
Female tissues 158 | 17,400
Skin and soft tissues 157 | 17,230
Nervous System 155 | 16,725
Blood and immune system 154 | 16,909
Liver and Pancreas 154 | 16,750
Male tissues 154 | 17,142
Urinary Tract 153 | 16,678
Respiratory system 152 | 16,393
Cardiovascular System 145 | 15,192

Target Family

Non-IDG 81 | 12,091
Enzyme 43 | 4,145
Transcription Factor 9 | 1,400
Epigenetic 8 | 242
Kinase 6 | 634
Transporter 5 | 473
Ion Channel 4 | 344
GPCR 3 | 408
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RAB6A-GEF complex partner protein 1 RIC1 Tbio Non-IDG -1.24586 19.1 10
tRNA methyltransferase 10 homolog A TRMT10A Tbio Enzyme -1.10123 12.2 75
Mesoderm induction early response protein 1 MIER1 Tbio Non-IDG -2.21641 165.6 93
Folylpolyglutamate synthase, mitochondrial FPGS Tchem Enzyme -1.90018 79.8 131
Vacuole membrane protein 1 VMP1 Tbio Non-IDG -2.49755 302.1 137
Suppression of tumorigenicity 18 protein ST18 Tbio Transcription Factor -0.30549 1.95 183
Chromodomain-helicase-DNA-binding protein 7 CHD7 Tbio Epigenetic -2.91077 788.8 102
Nuclear receptor subfamily 6 group A member 1 NR6A1 Tbio Nuclear Receptor -2.36193 227.5 236
Tubulin--tyrosine ligase-like protein 12 TTLL12 Tbio Enzyme -0.67312 5.81 112
Histone-lysine N-methyltransferase KMT5B KMT5B Tbio Epigenetic -1.20275 14.3 158