Development Level

Tbio 78 | 10,625
Tdark 13 | 7,003
Tchem 12 | 1,890
Tclin 5 | 602

Collection

Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

decreased body length 108 | 108
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 63 | 8,484
osteosarcoma 60 | 7,933
medulloblastoma, large-cell 54 | 6,234
glioblastoma 52 | 5,572
psoriasis 51 | 6,685
atypical teratoid / rhabdoid tumor 43 | 4,369
lung cancer 33 | 4,466
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,956
malignant mesothelioma 31 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,289
pilocytic astrocytoma 27 | 3,086
Breast cancer 26 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,988
primitive neuroectodermal tumor 25 | 3,031
Cancer 23 | 2,346
pediatric high grade glioma 23 | 2,712
ependymoma 21 | 2,514
lung carcinoma 21 | 2,844
Pick disease 20 | 1,893
oligodendroglioma 20 | 2,849
adult high grade glioma 19 | 2,148
Carcinoma 18 | 2,147
subependymal giant cell astrocytoma 18 | 2,287
lung adenocarcinoma 17 | 2,713
group 4 medulloblastoma 16 | 1,875
interstitial cystitis 16 | 2,299
invasive ductal carcinoma 16 | 2,950
non-small cell lung cancer 16 | 2,798
pancreatic cancer 16 | 2,300
ulcerative colitis 16 | 2,087
colon cancer 14 | 1,475
group 3 medulloblastoma 14 | 2,254
juvenile dermatomyositis 14 | 1,189
acute quadriplegic myopathy 13 | 1,157
astrocytic glioma 13 | 2,241
pituitary cancer 13 | 1,972
primary pancreatic ductal adenocarcinoma 13 | 1,271
Rheumatoid Arthritis 12 | 1,160
cystic fibrosis 12 | 1,665
ductal carcinoma in situ 12 | 1,745
medulloblastoma 12 | 1,524
posterior fossa group A ependymoma 12 | 1,511
sonic hedgehog group medulloblastoma 12 | 1,482
Intellectual disability 11 | 573
astrocytoma 11 | 1,493
breast carcinoma 11 | 1,614
diabetes mellitus 11 | 1,663
adrenocortical carcinoma 10 | 1,427
esophageal adenocarcinoma 10 | 737
Down syndrome 9 | 548
Multiple myeloma 9 | 1,327
acute myeloid leukemia 9 | 780
cutaneous lupus erythematosus 9 | 1,056
dermatomyositis 9 | 933
posterior fossa group B ependymoma 8 | 1,530
Obesity 7 | 616
gastric carcinoma 7 | 832
nasopharyngeal carcinoma 7 | 1,056
progressive supranuclear palsy 7 | 674
spina bifida 7 | 1,064
tuberculosis 7 | 1,557
Atopic dermatitis 6 | 944
Duchenne muscular dystrophy 6 | 602
active Crohn's disease 6 | 918
aldosterone-producing adenoma 6 | 664
atypical teratoid/rhabdoid tumor 6 | 1,095
nephrosclerosis 6 | 329
non primary Sjogren syndrome sicca 6 | 840
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
tuberculosis and treatment for 6 months 6 | 686
Amyotrophic Lateral Sclerosis 5 | 431
Juvenile arthritis 5 | 124
Mammary Neoplasms 5 | 410
Neurodegenerative disease 5 | 383
Prostatic Neoplasms 5 | 471
primary Sjogren syndrome 5 | 789
urothelial carcinoma 5 | 318
Alzheimer's disease 4 | 644
Autistic Disorder 4 | 320
Epilepsy 4 | 346
Osteoporosis 4 | 257
Polycystic Ovary Syndrome 4 | 332
Vascular disease 4 | 281
active ulcerative colitis 4 | 477
Becker muscular dystrophy 3 | 187
Cardiovascular system disease 3 | 194
Colorectal Neoplasms 3 | 217
Crohn's disease 3 | 304
Gaucher disease type 1 3 | 171
Lung Neoplasms 3 | 171
Multiple Sclerosis 3 | 498
Parkinson's disease 3 | 364
Reperfusion Injury 3 | 84
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
glioblastoma multiforme 3 | 347
hereditary spastic paraplegia 3 | 313
limb girdle muscular dystrophy 2A 3 | 156
mucosa-associated lymphoid tissue lymphoma 3 | 480
pancreatic carcinoma 3 | 567
pterygium 3 | 74

Tissue

Cardiovascular System 108 | 17,958
Digestive Tract 108 | 18,473
Female tissues 108 | 18,647
Liver and Pancreas 108 | 18,136
Male tissues 108 | 17,969
Nervous System 108 | 18,561
Blood and immune system 107 | 17,995
Endocrine System 107 | 18,512
Respiratory system 107 | 17,484
Skin and soft tissues 107 | 18,115
Urinary Tract 107 | 18,444

Target Family

Non-IDG 44 | 11,971
Enzyme 34 | 4,146
Epigenetic 9 | 242
Transcription Factor 7 | 1,400
Kinase 5 | 634
Transporter 4 | 473
GPCR 3 | 406
Nuclear Receptor 2 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Ubiquitin carboxyl-terminal hydrolase 24 USP24 Tbio Enzyme -1.53939 36.4 61
Sodium-dependent phosphate transporter 2 SLC20A2 Tbio Transporter -2.18737 165.3 97
Inositol polyphosphate 1-phosphatase INPP1 Tbio Enzyme -1.22269 17.2 73
NAC-alpha domain-containing protein 1 NACAD Tbio Non-IDG -0.89395 7.61 52
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha PPP2R3A Tbio Enzyme -1.19072 14.4 144
Neurocalcin-delta NCALD Tbio Non-IDG -1.29236 20.2 87
Adhesion G protein-coupled receptor F5 ADGRF5 Tbio GPCR -0.84160 8.64 151
Glycogen synthase kinase-3 alpha GSK3A Tclin Kinase -1.81647 52.3 722
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.65191 464.3 66