Development Level

Tbio 34 | 11,445
Tdark 11 | 6,588
Tchem 5 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

decreased blood urea nitrogen ... 51 | 51
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 38 | 11,493
osteosarcoma 26 | 7,950
ovarian cancer 25 | 8,520
psoriasis 22 | 6,694
glioblastoma 18 | 5,792
lung carcinoma 18 | 2,843
medulloblastoma, large-cell 18 | 6,241
atypical teratoid / rhabdoid tumor 15 | 5,112
lung cancer 15 | 4,740
ependymoma 14 | 4,679
group 3 medulloblastoma 14 | 4,104
malignant mesothelioma 12 | 3,232
Breast cancer 11 | 3,578
non-small cell lung cancer 11 | 2,890
Astrocytoma, Pilocytic 10 | 3,081
invasive ductal carcinoma 10 | 2,951
interstitial cystitis 9 | 2,312
subependymal giant cell astrocytoma 9 | 2,287
adult high grade glioma 8 | 3,801
oligodendroglioma 8 | 2,850
pituitary cancer 8 | 1,972
primitive neuroectodermal tumor 8 | 3,035
Autosomal recessive predisposition 7 | 1,442
astrocytic glioma 7 | 2,597
cutaneous lupus erythematosus 7 | 1,057
group 4 medulloblastoma 7 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung adenocarcinoma 7 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
ulcerative colitis 7 | 1,819
Cancer 6 | 2,499
Kidney cancer 6 | 2,613
adrenocortical carcinoma 6 | 1,428
cystic fibrosis 6 | 1,696
nasopharyngeal carcinoma 6 | 1,058
pancreatic cancer 6 | 2,398
Multiple myeloma 5 | 1,332
Parkinson's disease 5 | 392
Rheumatoid arthritis 5 | 1,191
Schizophrenia 5 | 1,160
active Crohn's disease 5 | 922
active ulcerative colitis 5 | 764
astrocytoma 5 | 1,146
colon cancer 5 | 1,478
diabetes mellitus 5 | 1,728
esophageal adenocarcinoma 5 | 737
juvenile dermatomyositis 5 | 1,187
Alzheimer's disease 4 | 658
Intellectual disability 4 | 1,016
Liver Cirrhosis, Experimental 4 | 769
Obesity 4 | 678
Pick disease 4 | 1,894
dermatomyositis 4 | 966
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
Acquired scoliosis 3 | 281
Autistic Disorder 3 | 364
Cleft Palate 3 | 271
Curvature of spine 3 | 282
Endometriosis 3 | 540
Epilepsy 3 | 792
Hypertension 3 | 396
Hypertensive disease 3 | 292
Liver cancer 3 | 604
Melanoma 3 | 711
Multiple Sclerosis 3 | 540
Muscle hypotonia 3 | 571
Orbital separation excessive 3 | 244
Short neck 3 | 140
Toxic encephalopathy 3 | 141
acute myeloid leukemia 3 | 783
gastric carcinoma 3 | 807
pediatric high grade glioma 3 | 1,064
primary Sjogren syndrome 3 | 735
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074
tuberculosis 3 | 2,010
Amyotrophic lateral sclerosis 2 | 451
Atherosclerosis 2 | 291
Atopic dermatitis 2 | 952
Congenital Epicanthus 2 | 177
Craniosynostosis 2 | 74
Decreased joint mobility 2 | 53
Depressive disorder 2 | 409
Down syndrome 2 | 499
Hypercholesterolemia 2 | 44
Kidney disease 2 | 430
Myocardial Ischemia 2 | 169
Myopathy 2 | 185
Polycystic ovary syndrome 2 | 360
Seizures 2 | 596
acute quadriplegic myopathy 2 | 1,158
adrenocortical adenoma 2 | 131
aldosterone-producing adenoma 2 | 665
atypical teratoid/rhabdoid tumor 2 | 357
breast carcinoma 2 | 1,638
chronic lymphosyte leukemia 2 | 204
hepatocellular carcinoma 2 | 547
medulloblastoma 2 | 720
pancreatic carcinoma 2 | 562

Tissue

Endocrine System 50 | 18,159
Male tissues 50 | 17,142
Female tissues 49 | 17,400
Blood and immune system 48 | 16,909
Digestive Tract 48 | 17,369
Liver and Pancreas 48 | 16,750
Urinary Tract 48 | 16,678
Nervous System 47 | 16,725
Respiratory system 47 | 16,393
Skin and soft tissues 46 | 17,230
Cardiovascular System 43 | 15,192

Target Family

Non-IDG 24 | 12,091
Enzyme 15 | 4,145
Transcription Factor 5 | 1,400
Kinase 4 | 634
Epigenetic 2 | 242
GPCR 1 | 408

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity tyrosine-phosphorylation-regulated kinase 1B DYRK1B Tchem Kinase -1.63295 52.7 289
BAG family molecular chaperone regulator 3 BAG3 Tbio Non-IDG -2.26339 208.9 289
Putative ADP-ribosylation factor-like protein 5C ARL5C Tdark Enzyme 0.00000 1.00 39
Ras-related protein Rab-36 RAB36 Tdark Enzyme -0.51688 3.97 90
ETS domain-containing transcription factor ERF ERF Tbio Transcription Factor -2.42588 268.8 257
SKI/DACH domain-containing protein 1 SKIDA1 Tdark Non-IDG -0.23045 1.67 0
Complement C1r subcomponent-like protein C1RL Tbio Enzyme -0.57210 4.61 83
Ubiquitin carboxyl-terminal hydrolase 21 USP21 Tbio Enzyme -1.64460 44.9 288
Cysteine protease ATG4B ATG4B Tbio Enzyme -1.79492 58.3 416
Heat shock factor 2-binding protein HSF2BP Tdark Non-IDG -0.21085 1.43 71