Development Level

Tbio 15 | 10,625
Tchem 5 | 1,890
Tdark 5 | 7,003
Tclin 1 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

decreased CD8-positive, alpha-... 26 | 26
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 19 | 8,484
psoriasis 16 | 6,685
medulloblastoma, large-cell 14 | 6,234
osteosarcoma 14 | 7,933
lung cancer 12 | 4,466
glioblastoma 10 | 5,572
pilocytic astrocytoma 10 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
pediatric high grade glioma 9 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
invasive ductal carcinoma 8 | 2,950
lung adenocarcinoma 7 | 2,713
lung carcinoma 7 | 2,844
non-small cell lung cancer 7 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
ductal carcinoma in situ 6 | 1,745
malignant mesothelioma 6 | 3,162
Breast cancer 5 | 3,094
Cancer 5 | 2,346
atypical teratoid / rhabdoid tumor 5 | 4,369
breast carcinoma 5 | 1,614
group 3 medulloblastoma 5 | 2,254
hepatocellular carcinoma 5 | 532
primitive neuroectodermal tumor 5 | 3,031
subependymal giant cell astrocytoma 5 | 2,287
ulcerative colitis 5 | 2,087
Multiple myeloma 4 | 1,327
Pick disease 4 | 1,893
juvenile dermatomyositis 4 | 1,189
pancreatic cancer 4 | 2,300
posterior fossa group A ependymoma 4 | 1,511
primary Sjogren syndrome 4 | 789
spina bifida 4 | 1,064
tuberculosis 4 | 1,557
Asthma 3 | 349
acute quadriplegic myopathy 3 | 1,157
astrocytic glioma 3 | 2,241
atypical teratoid/rhabdoid tumor 3 | 1,095
colon cancer 3 | 1,475
cutaneous lupus erythematosus 3 | 1,056
cystic fibrosis 3 | 1,665
ependymoma 3 | 2,514
group 4 medulloblastoma 3 | 1,875
interstitial cystitis 3 | 2,299
Carcinoma 2 | 2,147
Congenital disorder of glycosylation 2 | 53
Idiopathic generalized epilepsy 2 | 15
Intellectual disability 2 | 573
Juvenile myoclonic epilepsy 2 | 17
Keratoconus 2 | 47
Rheumatoid Arthritis 2 | 1,160
Vascular disease 2 | 281
active Crohn's disease 2 | 918
active ulcerative colitis 2 | 477
adrenocortical carcinoma 2 | 1,427
adult high grade glioma 2 | 2,148
astrocytoma 2 | 1,493
dermatomyositis 2 | 933
diabetes mellitus 2 | 1,663
fibroadenoma 2 | 557
gastric cancer 2 | 430
gastric carcinoma 2 | 832
medulloblastoma 2 | 1,524
mucosa-associated lymphoid tissue lymphoma 2 | 480
nasopharyngeal carcinoma 2 | 1,056
non primary Sjogren syndrome sicca 2 | 840
oligodendroglioma 2 | 2,849
pancreatic carcinoma 2 | 567
posterior fossa group B ependymoma 2 | 1,530
progressive supranuclear palsy 2 | 674
sarcoidosis 2 | 358
sonic hedgehog group medulloblastoma 2 | 1,482
tuberculosis and treatment for 6 months 2 | 686
Adenoid Cystic Carcinoma 1 | 99
Amblyopia 1 | 24
Amyotrophic Lateral Sclerosis 1 | 431
Brain infarction 1 | 17
Cerebrovascular accident 1 | 44
Chronic obstructive pulmonary disease 1 | 146
Coronary artery disease 1 | 240
Coronary heart disease 1 | 59
Degenerative polyarthritis 1 | 93
Disease Progression 1 | 125
Epilepsy 1 | 346
Glaucoma 1 | 134
IGA Glomerulonephritis 1 | 454
Inflammatory bowel disease 1 | 142
Kidney disease 1 | 396
Microcephaly 1 | 149
Neurodegenerative disease 1 | 383
Parkinson's disease 1 | 364
Peripheral vascular disease 1 | 90
Pneumonia 1 | 133
Stomach Neoplasms 1 | 282
cystic fibrosis and chronic rhinosinusitis 1 | 213
glioblastoma multiforme 1 | 347
hereditary spastic paraplegia 1 | 313
limb girdle muscular dystrophy 2B 1 | 74
substance-related disorder 1 | 105

Tissue

Cardiovascular System 26 | 17,958
Blood and immune system 25 | 17,995
Digestive Tract 25 | 18,473
Endocrine System 25 | 18,512
Female tissues 25 | 18,647
Liver and Pancreas 25 | 18,136
Male tissues 25 | 17,969
Nervous System 25 | 18,561
Respiratory system 25 | 17,484
Skin and soft tissues 25 | 18,115
Urinary Tract 25 | 18,444

Target Family

Enzyme 10 | 4,146
Non-IDG 10 | 11,971
Epigenetic 2 | 242
GPCR 2 | 406
Kinase 1 | 634
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interferon lambda receptor 1 IFNLR1 Tchem Non-IDG -1.48464 33.1 128
Bromodomain-containing protein 2 BRD2 Tchem Epigenetic -2.42927 0.00000 306
Guanine nucleotide exchange factor DBS MCF2L Tbio Non-IDG -0.93602 11.4 104
Abnormal spindle-like microcephaly-associated protein ASPM Tbio Non-IDG -1.42381 27.6 27
Histone deacetylase complex subunit SAP130 SAP130 Tdark Enzyme 0.00000 112
GTPase IMAP family member 6 GIMAP6 Tdark Enzyme -0.26912 2.01 57
Protein spinster homolog 2 SPNS2 Tbio Non-IDG -1.29998 23.3 69
DENN domain-containing protein 1B DENND1B Tbio Non-IDG -0.75315 6.46 116
Phosphatidylcholine:ceramide cholinephosphotransferase 1 SGMS1 Tbio Enzyme -1.54509 38.2 0
Lysine-specific demethylase 7A KDM7A Tchem Epigenetic -0.84590 8.81 77