Development Level

Tbio 5 | 11,445

IMPC Phenotype

decreased B cell number 5 | 5
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 4 | 11,493
osteosarcoma 3 | 7,950
Astrocytoma, Pilocytic 2 | 3,081
Clubfoot 2 | 39
atypical teratoid / rhabdoid tumor 2 | 5,112
glioblastoma 2 | 5,792
spina bifida 2 | 1,074
Abnormality of the respiratory system 1 | 4
Alobar Holoprosencephaly 1 | 14
Anencephaly 1 | 26
Appendicitis 1 | 15
Arthrogryposis-like syndrome 1 | 1
Atrial Septal Defects 1 | 85
Autosomal recessive predisposition 1 | 1,442
Bronchiectasis 1 | 64
Bruck syndrome 1 | 10
Bruck syndrome 1 1 | 1
Cholecystitis 1 | 18
Cholelithiasis 1 | 33
Chromosome 18p deletion syndrome 1 | 5
Chronic obstructive pulmonary disease 1 | 184
Cleft Lip 1 | 141
Cleft Palate 1 | 271
Congenital heart disease 1 | 93
Cystic lymphangioma 1 | 19
Dandy-Walker Syndrome 1 | 39
Dentinogenesis imperfecta 1 | 25
Discordant ventriculoarterial connection 1 | 17
Esophageal atresia 1 | 43
Fetal Growth Retardation 1 | 189
Galactosemia 1 | 19
Heterotaxy, Visceral, 5, Autosomal 1 | 1
Holoprosencephaly 1 | 56
Hydrocephalus 1 | 152
Imperforate anus 1 | 25
Infant, Small for Gestational Age 1 | 176
Intestinal Obstruction 1 | 31
Intrauterine retardation 1 | 176
Kuskokwim syndrome 1 | 1
Lobar Holoprosencephaly 1 | 20
MACULAR DEGENERATION, AGE-RELATED, 4 (disorder) 1 | 2
Microcephaly 1 | 166
Microphthalmia 1 | 76
Neurohypophyseal diabetes insipidus 1 | 13
OSTEOGENESIS IMPERFECTA, TYPE XI 1 | 1
Omphalocele 1 | 24
Osteogenesis Imperfecta, Type 11 1 | 1
Osteogenesis Imperfecta, Type 12 1 | 2
Osteogenesis imperfecta 1 | 34
Osteogenesis imperfecta type III (disorder) 1 | 11
Osteogenesis imperfecta type IV (disorder) 1 | 10
Parovarian cyst 1 | 1
Patau syndrome 1 | 14
Pertussis 1 | 20
Polydactyly 1 | 107
Primary ciliary dyskinesia 1 | 76
Right atrial isomerism 1 | 29
Scoliosis 1 | 44
Semilobar Holoprosencephaly 1 | 14
Septooptic dysplasia 1 | 19
Sinusitis 1 | 65
Situs Inversus 1 | 65
Situs ambiguous 1 | 8
Situs ambiguus 1 | 25
Ventricular Septal Defects 1 | 119
Visceral heterotaxy 1 | 14
Visceral heterotaxy 5, autosomal 1 | 1
adult high grade glioma 1 | 3,801
agnathia-otocephaly complex 1 | 8
cystic fibrosis 1 | 1,696
diabetes mellitus 1 | 1,728
ependymoma 1 | 4,679
group 3 medulloblastoma 1 | 4,104
lung cancer 1 | 4,740
medulloblastoma 1 | 720
medulloblastoma, large-cell 1 | 6,241
non-small cell lung cancer 1 | 2,890
osteogenesis imperfecta type 3 1 | 11
osteogenesis imperfecta type 4 1 | 10
ovarian cancer 1 | 8,520
pediatric high grade glioma 1 | 1,064
pituitary cancer 1 | 1,972
post-thrombotic syndrome 1 | 7
posterior fossa group A ependymoma 1 | 468
primitive neuroectodermal tumor 1 | 3,035
psoriasis 1 | 6,694
sonic hedgehog group medulloblastoma 1 | 467
tuberculosis 1 | 2,010

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Enzyme 3 | 4,145
Non-IDG 2 | 12,091

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Peptidyl-prolyl cis-trans isomerase FKBP10 FKBP10 Tbio Enzyme -1.59237 44.2 183
RAB6A-GEF complex partner protein 1 RIC1 Tbio Non-IDG -1.24586 19.1 10
E3 ubiquitin-protein ligase MARCH9 MARCH9 Tbio Enzyme -0.95067 9.88 119
Nodal homolog NODAL Tbio Non-IDG -3.00545 981.7 245
Rhomboid-related protein 4 RHBDD1 Tbio Enzyme -0.96627 10.1 47