Development Level

Tbio 10 | 11,445
Tchem 2 | 1,598
Tclin 1 | 613

IMPC Phenotype

convulsive seizures 13 | 13
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 8 | 11,493
psoriasis 8 | 6,694
medulloblastoma, large-cell 5 | 6,241
Astrocytoma, Pilocytic 4 | 3,081
astrocytic glioma 4 | 2,597
atypical teratoid / rhabdoid tumor 4 | 5,112
ependymoma 4 | 4,679
glioblastoma 4 | 5,792
non-small cell lung cancer 4 | 2,890
oligodendroglioma 4 | 2,850
osteosarcoma 4 | 7,950
ovarian cancer 4 | 8,520
primitive neuroectodermal tumor 4 | 3,035
Breast cancer 3 | 3,578
adult high grade glioma 3 | 3,801
group 3 medulloblastoma 3 | 4,104
pancreatic cancer 3 | 2,398
tuberculosis 3 | 2,010
Acquired metabolic disease 2 | 336
Allergic rhinitis 2 | 94
Cardiovascular system disease 2 | 246
Cutis Laxa 2 | 39
Kidney cancer 2 | 2,613
Pick disease 2 | 1,894
Schizophrenia 2 | 1,160
chronic rhinosinusitis 2 | 512
gastric carcinoma 2 | 807
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
juvenile dermatomyositis 2 | 1,187
lung cancer 2 | 4,740
lung carcinoma 2 | 2,843
pituitary cancer 2 | 1,972
subependymal giant cell astrocytoma 2 | 2,287
Areflexia of lower limbs 1 | 9
Astigmatism 1 | 54
Autistic Disorder 1 | 364
Babinski Reflex 1 | 100
Bladder Neoplasm 1 | 112
Blindness 1 | 88
Bronchitis 1 | 43
Cerebellar Dysmetria 1 | 56
Ciliopathy 1 | 71
Cluster headache syndrome 1 | 8
Common cold 1 | 67
Congenital disorder of glycosylation 1 | 54
Congenital myasthenic syndrome 1 | 25
Entropion 1 | 22
Exfoliation Syndrome 1 | 12
Galactosemia 1 | 19
Guillain-Barre syndrome 1 | 14
Hemolytic anemia 1 | 77
Hermansky-Pudlak syndrome 1 | 42
Hyperopia 1 | 70
Hyporeflexia of lower limbs 1 | 10
Intracranial aneurysm 1 | 24
Iris disease 1 | 10
Kabuki syndrome 1 | 27
Lewy Body Disease 1 | 21
Liver disease 1 | 237
Macroglobulinemia 1 | 18
Melanoma 1 | 711
Metachromatic leukodystrophy 1 | 14
Monoclonal gammopathy of uncertain significance 1 | 4
Multiple system atrophy 1 | 29
Myocardial Perfusion Imaging Adjunct 1 | 25
Nasal congestion 1 | 21
Nasal discharge 1 | 24
Neoplasm Metastasis 1 | 168
Netherton syndrome 1 | 15
Neurodegenerative disease 1 | 414
Neuropathy 1 | 261
Ornithosis 1 | 9
POEMS syndrome 1 | 6
Pain 1 | 103
Paraparesis, Spastic 1 | 16
Parkinson Disease 1 | 64
Paroxysmal supraventricular tachycardia 1 | 12
Pigment dispersion syndrome 1 | 11
Platelet storage pool deficiency 1 | 21
Polyneuropathy 1 | 64
Prenatal Injuries 1 | 11
Pulmonary emphysema 1 | 48
Reduced visual acuity 1 | 63
Retinitis pigmentosa 28 1 | 19
Retinitis pigmentosa 67 1 | 5
Sepsis 1 | 24
Skin cancer 1 | 469
Spasticity 1 | 26
Tension-type headache 1 | 10
Urinary Bladder Neoplasms 1 | 114
Urinary bladder cancer 1 | 36
Vascular headache 1 | 7
cone-rod dystrophy 1 | 59
cystic fibrosis and chronic rhinosinusitis 1 | 214
fascioscapulohumeral muscular dystrophy 1 | 100
hereditary spastic paraplegia 1 | 318
interstitial lung disease 1 | 298

Tissue

Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Male tissues 13 | 17,142
Skin and soft tissues 13 | 17,230
Blood and immune system 12 | 16,909
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Urinary Tract 12 | 16,678
Cardiovascular System 11 | 15,192

Target Family

Non-IDG 7 | 12,091
Enzyme 4 | 4,145
GPCR 1 | 408
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myosin-IIIb MYO3B Tbio Kinase -0.73450 5.14 127
Lysyl oxidase homolog 1 LOXL1 Tbio Enzyme -2.55611 364.6 174
Protein FAM161A FAM161A Tbio Non-IDG -1.10138 14.2 50
Tubulin polymerization-promoting protein TPPP Tbio Non-IDG -1.95532 92.5 179
O-acetyl-ADP-ribose deacetylase MACROD2 MACROD2 Tbio Enzyme -1.21785 14.5 19
SNARE-associated protein Snapin SNAPIN Tbio Non-IDG -1.65821 50.9 69
Myosin-1 MYH1 Tbio Non-IDG -1.94251 72.6 122
Alpha-1,3/1,6-mannosyltransferase ALG2 ALG2 Tbio Enzyme -1.27016 16.1 151
Synapsin-3 SYN3 Tbio Non-IDG -1.99912 100.6 110
Adenosine receptor A2b ADORA2B Tclin GPCR -2.05073 105.4 198