Development Level

Tbio 13 | 11,651
Tchem 3 | 1,388
Tclin 1 | 612
Tdark 1 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

abnormal vertebrae morphology 18 | 18
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 12 | 11,493
osteosarcoma 11 | 7,950
atypical teratoid / rhabdoid tumor 10 | 5,112
medulloblastoma, large-cell 10 | 6,241
psoriasis 10 | 6,694
glioblastoma 9 | 5,792
ovarian cancer 9 | 8,520
malignant mesothelioma 7 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
ependymoma 5 | 4,679
group 3 medulloblastoma 5 | 4,104
lung cancer 5 | 4,740
primitive neuroectodermal tumor 5 | 3,035
Astrocytoma, Pilocytic 4 | 3,081
Autosomal recessive predisposition 4 | 1,442
Kidney cancer 4 | 2,613
adult high grade glioma 4 | 3,801
group 4 medulloblastoma 4 | 1,855
invasive ductal carcinoma 4 | 2,951
lung carcinoma 4 | 2,843
Alzheimer's disease 3 | 658
Breast cancer 3 | 3,578
Cancer 3 | 2,499
Cataract 3 | 297
cystic fibrosis 3 | 1,696
gastric carcinoma 3 | 807
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung adenocarcinoma 3 | 2,716
Alkaline phosphatase serum increased 2 | 29
Alopecia 2 | 115
Arthralgia 2 | 90
Bone pain 2 | 42
Calcinosis 2 | 70
Craniofacial Abnormalities 2 | 151
Failure to gain weight 2 | 365
Femoral bowing 2 | 20
Fibular bowing 2 | 5
Frontal bossing 2 | 157
Genu varum 2 | 29
Hepatomegaly 2 | 285
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hyperparathyroidism 2 | 48
Hyperphosphatemia 2 | 32
Hypertension 2 | 396
Hypophosphatemia 2 | 40
Increased serum parathyroid hormone 2 | 14
Lens Opacities 2 | 231
Metaphyseal irregularity 2 | 23
Multiple Sclerosis 2 | 540
Muscle hypotonia 2 | 571
Osteomalacia 2 | 35
Osteopetrosis 2 | 43
Parkinson's disease 2 | 392
Pediatric failure to thrive 2 | 365
Phenotypic variability 2 | 150
Pick disease 2 | 1,894
Rheumatoid arthritis 2 | 1,191
Rickets 2 | 49
Schizophrenia 2 | 1,160
Splenomegaly 2 | 190
Tibial bowing 2 | 19
active ulcerative colitis 2 | 764
astrocytic glioma 2 | 2,597
chronic lymphosyte leukemia 2 | 204
colon cancer 2 | 1,478
juvenile dermatomyositis 2 | 1,187
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
progressive supranuclear palsy 2 | 676
subependymal giant cell astrocytoma 2 | 2,287
Addison's disease 1 | 31
Aortic Valve, Calcification of 1 | 3
Aortic valve calcification 1 | 5
Aortic valve stenosis 1 | 28
Cherubism 1 | 13
Chronic diarrhea 1 | 29
Diabetes Mellitus, Insulin-Dependent 1 | 48
Diabetes Mellitus, Type 1 1 | 43
Dystrophic toenail changes 1 | 12
Eczema 1 | 45
Familial Hypophosphatemic Rickets 1 | 2
Flattening of the talar dome 1 | 1
Fluorosis of tooth enamel 1 | 2
Hypoketotic hypoglycemia 1 | 11
Hypomineralization of enamel of tooth 1 | 2
Increased porosity of tooth enamel 1 | 2
Leukemia, T-Cell 1 | 5
Microcephaly, Primary Autosomal Recessive, 6 1 | 1
Myalgia 1 | 54
Primary autosomal recessive microcephaly 6 1 | 1
Renal phosphate wasting 1 | 7
SECKEL SYNDROME 4 1 | 1
Spinal canal stenosis 1 | 12
T-Lymphocytopenia 1 | 9
White spot lesions of tooth enamel 1 | 2

Tissue

Blood and immune system 18 | 16,909
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678
Nervous System 17 | 16,725
Respiratory system 17 | 16,393
Cardiovascular System 15 | 15,192

Target Family

Non-IDG 8 | 12,091
Enzyme 6 | 4,145
Transcription Factor 2 | 1,400
Epigenetic 1 | 242
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Collectin-10 COLEC10 Tbio Non-IDG -0.11764 1.02 84
Phosphate-regulating neutral endopeptidase PHEX Tbio Enzyme -3.26526 1840.1 104
Sorting nexin-5 SNX5 Tbio Non-IDG -1.23706 20.8 141
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.70628 492.9 68
Histone-lysine N-methyltransferase SETMAR SETMAR Tbio Epigenetic -1.33346 26.5 119
Interleukin-2 receptor subunit alpha IL2RA Tclin Non-IDG -3.02107 927.8 1917
Histone H2A deubiquitinase MYSM1 MYSM1 Tbio Transcription Factor -1.76987 62.1 184
Dual oxidase maturation factor 2 DUOXA2 Tbio Enzyme -1.35199 19.7 84
Neurogenic locus notch homolog protein 1 NOTCH1 Tchem Non-IDG -4.08071 11843.2 916
Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 Tchem Enzyme -2.28515 186.9 359