Development Level

Tbio 9 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

abnormal urinary bladder morph... 11 | 11
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 7 | 11,493
ovarian cancer 7 | 8,520
osteosarcoma 6 | 7,950
glioblastoma 5 | 5,792
lung cancer 5 | 4,740
atypical teratoid / rhabdoid tumor 4 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
medulloblastoma, large-cell 4 | 6,241
psoriasis 4 | 6,694
Cancer 3 | 2,499
ductal carcinoma in situ 3 | 1,745
ependymoma 3 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
lung carcinoma 3 | 2,843
medulloblastoma 3 | 720
pancreatic cancer 3 | 2,398
pediatric high grade glioma 3 | 1,064
Kidney cancer 2 | 2,613
Stomach Neoplasms 2 | 300
active Crohn's disease 2 | 922
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
dermatomyositis 2 | 966
esophageal adenocarcinoma 2 | 737
interstitial cystitis 2 | 2,312
nephrosclerosis 2 | 333
oligodendroglioma 2 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primary Sjogren syndrome 2 | 735
spina bifida 2 | 1,074
ulcerative colitis 2 | 1,819
Acidosis, Lactic 1 | 97
Ascariasis 1 | 7
Autistic Disorder 1 | 364
Barrett's esophagus 1 | 182
Bladder Neoplasm 1 | 112
Blepharoptosis 1 | 231
Carcinoma, Transitional Cell 1 | 32
Colorectal Neoplasms 1 | 243
Congenital hemolytic anemia 1 | 32
Diarrhea 1 | 253
Diphtheria 1 | 40
Dysgraphia 1 | 20
Erythromelalgia 1 | 7
Esotropia 1 | 31
Essential thrombocythemia 1 | 10
Essential tremor 1 | 28
Exotropia 1 | 35
Fatigue 1 | 182
Frontal bossing 1 | 157
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hartnup disease 1 | 13
Heart conduction disease 1 | 83
Hereditary renal cell carcinoma 1 | 3
Highly variable severity 1 | 157
Hyperinsulinism 1 | 133
Hypocalcemia 1 | 32
Hypoglycemia 1 | 152
Kidney Failure 1 | 111
Lactic acidemia 1 | 95
Laron syndrome 1 | 6
Liver Cirrhosis, Experimental 1 | 769
Liver disease 1 | 237
Long QT syndrome 1 1 | 20
Long eyelashes 1 | 37
Long narrow head 1 | 75
Lysinuric protein intolerance 1 | 15
Melanoma 1 | 711
Meningioma 1 | 41
Moderate mental retardation (I.Q. 35-49) 1 | 28
Narrow cranium shape 1 | 75
Narrow head shape 1 | 75
Narrow skull shape 1 | 75
Osteoporosis 1 | 363
Polycythemia vera 1 | 27
Poor growth 1 | 114
Recurrent urinary tract infection 1 | 24
Reduced fetal movement 1 | 51
Renal Insufficiency 1 | 90
Renal failure in adulthood 1 | 76
Retinopathy of prematurity 1 | 22
Retrognathia 1 | 54
Rhinitis 1 | 54
Romano-Ward Syndrome 1 | 12
Silver-Russell syndrome 1 | 39
Toxic encephalopathy 1 | 141
Turner syndrome 1 | 28
Turridolichocephaly 1 | 75
Urinary Bladder Neoplasms 1 | 114
Variable expressivity 1 | 157
Very poor growth 1 | 114
Williams-Beuren syndrome 1 | 50
cystic fibrosis and chronic rhinosinusitis 1 | 214
facioscapulohumeral dystrophy 1 | 288
posterior fossa group A ependymoma 1 | 468

Tissue

Blood and immune system 11 | 16,909
Cardiovascular System 11 | 15,192
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678

Target Family

Non-IDG 4 | 12,091
Enzyme 3 | 4,145
Ion Channel 1 | 344
Kinase 1 | 634
Transcription Factor 1 | 1,400
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thymocyte selection-associated high mobility group box protein TOX TOX Tbio Transcription Factor -2.98637 953.0 77
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein NOS1AP Tbio Enzyme -2.13262 142.6 159
Protein ABHD11 ABHD11 Tbio Enzyme -0.85496 5.74 96
COP9 signalosome complex subunit 7a COPS7A Tbio Non-IDG -1.50943 32.2 154
Neutral and basic amino acid transport protein rBAT SLC3A1 Tbio Transporter -2.60836 401.8 140
E3 ubiquitin-protein ligase ARIH2 ARIH2 Tbio Enzyme -1.44450 28.4 251
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.20657 183.7 368
Piezo-type mechanosensitive ion channel component 1 PIEZO1 Tbio Ion Channel -2.13444 126.8 83
Eukaryotic translation initiation factor 4E transporter EIF4ENIF1 Tbio Non-IDG -1.60874 36.7 242
Insulin-like growth factor-binding protein 3 IGFBP3 Tchem Non-IDG -3.35760 2176.5 510