Development Level

Tbio 12 | 11,445
Tchem 2 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

abnormal tibia morphology 14 | 14
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 10 | 11,493
glioblastoma 10 | 5,792
ovarian cancer 9 | 8,520
osteosarcoma 8 | 7,950
adult high grade glioma 7 | 3,801
ependymoma 7 | 4,679
Astrocytoma, Pilocytic 6 | 3,081
atypical teratoid / rhabdoid tumor 6 | 5,112
invasive ductal carcinoma 6 | 2,951
medulloblastoma, large-cell 6 | 6,241
psoriasis 6 | 6,694
Kidney cancer 5 | 2,613
cystic fibrosis 5 | 1,696
lung cancer 5 | 4,740
primitive neuroectodermal tumor 5 | 3,035
adrenocortical carcinoma 4 | 1,428
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
Autosomal recessive predisposition 3 | 1,442
Breast cancer 3 | 3,578
Genu varum 3 | 29
Muscle hypotonia 3 | 571
Pick disease 3 | 1,894
Prostatic Neoplasms 3 | 495
Short stature 3 | 531
astrocytic glioma 3 | 2,597
colon cancer 3 | 1,478
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
oligodendroglioma 3 | 2,850
pituitary cancer 3 | 1,972
ulcerative colitis 3 | 1,819
Alkaline phosphatase serum increased 2 | 29
Arthralgia 2 | 90
Atopic dermatitis 2 | 952
Bone pain 2 | 42
Cancer 2 | 2,499
Cataract 2 | 297
Degenerative polyarthritis 2 | 115
Femoral bowing 2 | 20
Fibular bowing 2 | 5
Frontal bossing 2 | 157
Hyperparathyroidism 2 | 48
Hyperphosphatemia 2 | 32
Hypophosphatemia 2 | 40
Hypotrophic malar bone 2 | 129
Increased serum parathyroid hormone 2 | 14
Intellectual disability 2 | 1,016
Malar flattening 2 | 129
Metaphyseal irregularity 2 | 23
Motor delay 2 | 147
No development of motor milestones 2 | 147
Osteomalacia 2 | 35
Rickets 2 | 49
Tibial bowing 2 | 19
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
aldosterone-producing adenoma 2 | 665
gastric carcinoma 2 | 807
group 3 medulloblastoma 2 | 4,104
juvenile dermatomyositis 2 | 1,187
non primary Sjogren syndrome sicca 2 | 891
non-small cell lung cancer 2 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
tuberculosis 2 | 2,010
urothelial carcinoma 2 | 318
Beading of ribs 1 | 6
Collapse of vertebra 1 | 14
Compression fracture of vertebral column 1 | 14
Compression of spinal cord 1 | 10
Congenital hypothyroidism 1 | 26
Decreased muscle mass 1 | 28
Degenerative disc disease 1 | 35
Dental abscess 1 | 4
Enthesitis 1 | 3
Enthesopathy 1 | 4
Extrinsic allergic alveolitis 1 | 6
Goiter 1 | 38
Hepatitis 1 | 67
Hypochondriasis 1 | 6
Hypophosphatemic Rickets, X-Linked Dominant 1 | 1
Iris disease 1 | 10
Irregular epiphyses 1 | 10
Irregular vertebral endplates 1 | 16
Irritation - emotion 1 | 68
Isolated growth hormone deficiency type III 1 | 1
Neoplasms, Experimental 1 | 40
Osteoblastoma 1 | 8
Osteogenesis imperfecta type IV (disorder) 1 | 10
Platyspondyly 1 | 56
Relative short stature 1 | 13
Renal tubular disorder 1 | 12
Short stature, mild 1 | 13
Thrombotic thrombocytopenic purpura 1 | 14
Tic disorder 1 | 8
Uremia 1 | 19
osteogenesis imperfecta type 4 1 | 10

Tissue

Blood and immune system 14 | 16,909
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Cardiovascular System 11 | 15,192

Target Family

Enzyme 6 | 4,145
Non-IDG 6 | 12,091
Epigenetic 1 | 242
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Centromere protein J CENPJ Tbio Non-IDG -1.79588 59.0 102
Complement C1r subcomponent-like protein C1RL Tbio Enzyme -0.57210 4.61 83
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 BNIP2 Tbio Non-IDG -1.54058 32.8 232
Long-chain-fatty-acid--CoA ligase 4 ACSL4 Tbio Enzyme -1.88239 83.9 249
Chromobox protein homolog 6 CBX6 Tchem Epigenetic -0.75383 5.29 190
Phosphate-regulating neutral endopeptidase PHEX Tbio Enzyme -3.26526 1840.1 104
START domain-containing protein 10 STARD10 Tbio Non-IDG -0.80706 8.08 77
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.70628 492.9 68
SPARC SPARC Tbio Non-IDG -3.10194 1136.1 543
Deoxyribonuclease-1-like 2 DNASE1L2 Tbio Enzyme -1.67313 48.8 23