Development Level

Tbio 41 | 11,651
Tdark 8 | 6,593
Tchem 4 | 1,388
Tclin 2 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

abnormal spleen morphology 55 | 55
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 32 | 11,493
ovarian cancer 28 | 8,520
psoriasis 25 | 6,694
osteosarcoma 23 | 7,950
medulloblastoma, large-cell 21 | 6,241
atypical teratoid / rhabdoid tumor 20 | 5,112
glioblastoma 19 | 5,792
group 3 medulloblastoma 17 | 4,104
lung cancer 16 | 4,740
Breast cancer 14 | 3,578
invasive ductal carcinoma 14 | 2,951
ependymoma 12 | 4,679
adult high grade glioma 11 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
lung carcinoma 10 | 2,843
malignant mesothelioma 10 | 3,232
subependymal giant cell astrocytoma 10 | 2,287
interstitial cystitis 9 | 2,312
non-small cell lung cancer 9 | 2,890
pituitary cancer 9 | 1,972
primitive neuroectodermal tumor 9 | 3,035
cystic fibrosis 8 | 1,696
ductal carcinoma in situ 8 | 1,745
lung adenocarcinoma 8 | 2,716
oligodendroglioma 8 | 2,850
pancreatic cancer 8 | 2,398
breast carcinoma 7 | 1,638
spina bifida 7 | 1,074
Astrocytoma, Pilocytic 6 | 3,081
Cancer 6 | 2,499
Pick disease 6 | 1,894
adrenocortical carcinoma 6 | 1,428
astrocytic glioma 6 | 2,597
Prostatic Neoplasms 5 | 495
Rheumatoid arthritis 5 | 1,191
acute quadriplegic myopathy 5 | 1,158
tuberculosis 5 | 2,010
Autosomal recessive predisposition 4 | 1,442
Intellectual disability 4 | 1,016
Multiple myeloma 4 | 1,332
Schizophrenia 4 | 1,160
Stomach Neoplasms 4 | 300
acute myeloid leukemia 4 | 783
astrocytoma 4 | 1,146
colon cancer 4 | 1,478
diabetes mellitus 4 | 1,728
group 4 medulloblastoma 4 | 1,855
juvenile dermatomyositis 4 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primary pancreatic ductal adenocarcinoma 4 | 1,109
Cognitive delay 3 | 608
Disease Progression 3 | 136
Epilepsy 3 | 792
Global developmental delay 3 | 608
Kidney cancer 3 | 2,613
Liver cancer 3 | 604
Mental and motor retardation 3 | 608
active Crohn's disease 3 | 922
chronic rhinosinusitis 3 | 512
cutaneous lupus erythematosus 3 | 1,057
fibroadenoma 3 | 559
hepatocellular carcinoma 3 | 547
interstitial lung disease 3 | 298
posterior fossa group A ependymoma 3 | 468
ulcerative colitis 3 | 1,819
Arthritis, Rheumatoid 2 | 174
Asthma 2 | 385
Bladder Neoplasm 2 | 112
Breast Neoplasms 2 | 445
Bulbous nasal tip 2 | 48
Bulbous nose 2 | 48
Chronic Lymphocytic Leukemia 2 | 262
Crohn's disease 2 | 321
Dull intelligence 2 | 645
Endometriosis 2 | 540
Hypersensitivity reaction type II disease 2 | 253
Mammary Neoplasms 2 | 425
Mesothelioma, Malignant 2 | 105
Neoplasm Metastasis 2 | 168
Potato nose 2 | 48
Prenatal onset 2 | 139
Prostate cancer 2 | 175
Retrognathia 2 | 54
Seizures 2 | 596
Urinary Bladder Neoplasms 2 | 114
active ulcerative colitis 2 | 764
aldosterone-producing adenoma 2 | 665
atypical teratoid/rhabdoid tumor 2 | 357
chronic lymphosyte leukemia 2 | 204
gastric cancer 2 | 459
gastric carcinoma 2 | 807
hereditary spastic paraplegia 2 | 318
medulloblastoma 2 | 720
nephrosclerosis 2 | 333
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
progressive supranuclear palsy 2 | 676
sonic hedgehog group medulloblastoma 2 | 467

Tissue

Endocrine System 55 | 18,159
Female tissues 54 | 17,400
Digestive Tract 53 | 17,369
Liver and Pancreas 53 | 16,750
Male tissues 53 | 17,142
Urinary Tract 53 | 16,678
Blood and immune system 52 | 16,909
Nervous System 52 | 16,725
Skin and soft tissues 52 | 17,230
Respiratory system 51 | 16,393
Cardiovascular System 47 | 15,192

Target Family

Non-IDG 30 | 12,091
Enzyme 13 | 4,145
Kinase 6 | 634
Transcription Factor 3 | 1,400
Epigenetic 1 | 242
Ion Channel 1 | 344
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable E3 ubiquitin-protein ligase MID2 MID2 Tbio Enzyme -2.49198 303.4 152
Meiotic recombination protein SPO11 SPO11 Tbio Non-IDG -2.33263 208.9 148
Cyclin-dependent kinase-like 2 CDKL2 Tchem Kinase -1.25935 16.3 146
Crossover junction endonuclease EME1 EME1 Tbio Enzyme -1.69458 48.2 143
RING finger protein 10 RNF10 Tbio Non-IDG -0.83249 6.53 141
Neutral and basic amino acid transport protein rBAT SLC3A1 Tbio Transporter -2.60836 401.8 140
Netrin-4 NTN4 Tbio Non-IDG -1.39922 32.7 139
Integral membrane protein DGCR2/IDD DGCR2 Tbio Non-IDG -0.89854 6.77 126
Gap junction beta-4 protein GJB4 Tbio Non-IDG -1.60100 40.2 125
Glycerophosphodiester phosphodiesterase domain-containing protein 5 GDPD5 Tbio Enzyme -1.19911 17.6 110