Development Level

Tbio 45 | 11,445
Tdark 16 | 6,588
Tchem 8 | 1,598
Tclin 1 | 613

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

abnormal sleep behavior 70 | 70
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 42 | 11,493
osteosarcoma 36 | 7,950
ovarian cancer 34 | 8,520
medulloblastoma, large-cell 33 | 6,241
psoriasis 32 | 6,694
glioblastoma 28 | 5,792
atypical teratoid / rhabdoid tumor 27 | 5,112
ependymoma 24 | 4,679
lung cancer 23 | 4,740
Astrocytoma, Pilocytic 21 | 3,081
non-small cell lung cancer 20 | 2,890
Breast cancer 19 | 3,578
group 3 medulloblastoma 19 | 4,104
adult high grade glioma 18 | 3,801
oligodendroglioma 17 | 2,850
astrocytic glioma 16 | 2,597
lung adenocarcinoma 16 | 2,716
lung carcinoma 16 | 2,843
primitive neuroectodermal tumor 15 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
malignant mesothelioma 14 | 3,232
interstitial cystitis 13 | 2,312
invasive ductal carcinoma 13 | 2,951
pancreatic cancer 13 | 2,398
Cancer 12 | 2,499
Kidney cancer 11 | 2,613
subependymal giant cell astrocytoma 11 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
ulcerative colitis 10 | 1,819
Pick disease 9 | 1,894
cystic fibrosis 9 | 1,696
ductal carcinoma in situ 9 | 1,745
group 4 medulloblastoma 9 | 1,855
Schizophrenia 8 | 1,160
pituitary cancer 8 | 1,972
primary pancreatic ductal adenocarcinoma 8 | 1,109
Duchenne muscular dystrophy 7 | 601
diabetes mellitus 7 | 1,728
juvenile dermatomyositis 7 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
primary Sjogren syndrome 7 | 735
Autosomal recessive predisposition 6 | 1,442
Down syndrome 6 | 499
Endometriosis 6 | 540
Melanoma 6 | 711
cutaneous lupus erythematosus 6 | 1,057
tuberculosis 6 | 2,010
Atopic dermatitis 5 | 952
Liver Cirrhosis, Experimental 5 | 769
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
pediatric high grade glioma 5 | 1,064
spina bifida 5 | 1,074
Autistic Disorder 4 | 364
Prostatic Neoplasms 4 | 495
Rheumatoid arthritis 4 | 1,191
Short stature 4 | 531
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
breast carcinoma 4 | 1,638
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 559
limb girdle muscular dystrophy 2A 4 | 213
medulloblastoma 4 | 720
tuberculosis and treatment for 6 months 4 | 409
Adenocarcinoma of lung 3 | 142
Alzheimer's disease 3 | 658
Arthritis, Rheumatoid 3 | 174
Breast Neoplasms 3 | 445
Cataract 3 | 297
Cognitive delay 3 | 608
Colorectal Neoplasms 3 | 243
Depressive disorder 3 | 409
Glaucoma 3 | 239
Global developmental delay 3 | 608
Mammary Neoplasms 3 | 425
Mental and motor retardation 3 | 608
Multiple Sclerosis 3 | 540
Multiple myeloma 3 | 1,332
Neoplasms 3 | 63
Neurodegenerative disease 3 | 414
Nystagmus 3 | 317
Obesity 3 | 678
active Crohn's disease 3 | 922
aldosterone-producing adenoma 3 | 665
chronic rhinosinusitis 3 | 512
colon cancer 3 | 1,478
dermatomyositis 3 | 966
gastric carcinoma 3 | 807
nasopharyngeal carcinoma 3 | 1,058
posterior fossa group A ependymoma 3 | 468
progressive supranuclear palsy 3 | 676
Bipolar Disorder 2 | 666
Contact Dermatitis 2 | 81
Vascular disease 2 | 319
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
hepatocellular carcinoma 2 | 547
mucosa-associated lymphoid tissue lymphoma 2 | 484
non diabetic and post-ischemic heart failure 2 | 200

Tissue

Endocrine System 69 | 18,159
Digestive Tract 68 | 17,369
Male tissues 68 | 17,142
Skin and soft tissues 68 | 17,230
Female tissues 65 | 17,400
Liver and Pancreas 65 | 16,750
Respiratory system 65 | 16,393
Urinary Tract 65 | 16,678
Blood and immune system 64 | 16,909
Nervous System 64 | 16,725
Cardiovascular System 60 | 15,192

Target Family

Non-IDG 40 | 12,091
Enzyme 18 | 4,145
Transcription Factor 5 | 1,400
Transporter 4 | 473
GPCR 2 | 408
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Beta-citrylglutamate synthase B RIMKLB Tdark Enzyme -0.33579 2.63 48
Progesterone-induced-blocking factor 1 PIBF1 Tbio Non-IDG -1.30666 21.1 209
Zinc finger ZZ-type and EF-hand domain-containing protein 1 ZZEF1 Tdark Non-IDG 0.19 0.86 20
Adherens junction-associated protein 1 AJAP1 Tbio Non-IDG -1.20907 21.2 25
Transmembrane glycoprotein NMB GPNMB Tbio Non-IDG -2.05817 130.8 293
Membrane progestin receptor alpha PAQR7 Tbio Non-IDG -1.89212 76.1 122
Prenylated Rab acceptor protein 1 RABAC1 Tbio Non-IDG -1.75636 58.3 45
Ras-related protein Rap-2b RAP2B Tbio Enzyme -2.39691 181.1 192
Transmembrane protein 151B TMEM151B Tdark Non-IDG 0.00000 64