Development Level

Tbio 13 | 10,625
Tchem 6 | 1,890
Tdark 4 | 7,003

Collection

GPCR: IDG Consortium (Complete/Control) 1 | 24

IMPC Phenotype

abnormal skin morphology 23 | 23
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat-hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 17 | 8,491
psoriasis 13 | 6,685
lung cancer 9 | 4,473
medulloblastoma, large-cell 9 | 6,234
interstitial cystitis 8 | 2,299
osteosarcoma 8 | 7,933
glioblastoma 7 | 5,572
non-small cell lung cancer 7 | 2,798
Breast cancer 6 | 3,098
Cancer 6 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
invasive ductal carcinoma 6 | 2,950
lung carcinoma 6 | 2,844
adrenocortical carcinoma 5 | 1,427
atypical teratoid / rhabdoid tumor 5 | 4,369
group 4 medulloblastoma 5 | 1,875
lung adenocarcinoma 5 | 2,714
pancreatic cancer 5 | 2,300
pilocytic astrocytoma 5 | 3,086
astrocytic glioma 4 | 2,241
breast carcinoma 4 | 1,614
cystic fibrosis 4 | 1,670
malignant mesothelioma 4 | 3,163
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
ulcerative colitis 4 | 2,087
IGA Glomerulonephritis 3 | 454
Multiple myeloma 3 | 1,327
Neurodegenerative disease 3 | 383
Pick disease 3 | 1,893
acute quadriplegic myopathy 3 | 1,157
adult high grade glioma 3 | 2,148
chronic lymphosyte leukemia 3 | 232
colon cancer 3 | 1,475
ependymoma 3 | 2,514
non primary Sjogren syndrome sicca 3 | 840
oligodendroglioma 3 | 2,849
posterior fossa group B ependymoma 3 | 1,530
primary pancreatic ductal adenocarcinoma 3 | 1,271
spina bifida 3 | 1,064
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 1,563
Anemia 2 | 252
Bipolar Disorder 2 | 266
Crohn's disease 2 | 304
Epilepsy 2 | 346
Hypertension 2 | 293
Inflammatory bowel disease 2 | 142
Neuropathy 2 | 210
Obesity 2 | 616
Parkinson's disease 2 | 364
Rheumatoid Arthritis 2 | 1,170
atypical teratoid/rhabdoid tumor 2 | 1,095
cutaneous lupus erythematosus 2 | 1,056
diabetes mellitus 2 | 1,663
group 3 medulloblastoma 2 | 2,254
hepatocellular carcinoma 2 | 550
mucosa-associated lymphoid tissue lymphoma 2 | 480
nasopharyngeal carcinoma 2 | 1,056
pancreatic carcinoma 2 | 567
pediatric high grade glioma 2 | 2,712
primitive neuroectodermal tumor 2 | 3,031
urothelial carcinoma 2 | 318
Acquired immunodeficiency syndrome 1 | 164
Adult junctional epidermolysis bullosa (disorder) 1 | 5
Amelogenesis imperfecta 1 | 26
Amelogenesis imperfecta 1A 1 | 1
Amelogenesis imperfecta local hypoplastic form 1 | 1
Brain edema 1 | 26
Charcot-Marie-Tooth disease 1 | 74
Cholera 1 | 33
Chorea Acanthocytosis Syndrome 1 | 2
Complex regional pain syndrome 1 | 12
Dental enamel hypoplasia 1 | 12
Diarrhea 1 | 155
Epidermolysis bullosa 1 | 21
Epidermolysis bullosa, junctional, Herlitz type 1 | 3
Fatty liver disease 1 | 86
Generalized atrophic benign epidermolysis bullosa 1 | 3
Hepatic encephalopathy 1 | 25
Herlitz Disease 1 | 3
Hyperkalemic periodic paralysis 1 | 10
Hypokalemia 1 | 40
Hypokalemic periodic paralysis 1 | 13
Junctional epidermolysis bullosa 1 | 9
Legg-Calve-Perthes Disease 1 | 8
Metabolic acidosis 1 | 49
Myoclonic Epilepsies, Progressive 1 | 12
Neoplasm Recurrence, Local 1 | 23
Pancreatitis 1 | 97
Primary immunodeficiency disease 1 | 52
Rectal prolapse 1 | 12
Sideroblastic anemia 1 | 18
Skin disease 1 | 65
St. Louis encephalitis 1 | 5
Succinic semialdehyde dehydrogenase deficiency 1 | 16
axial spondyloarthropathy 1 | 28
interstitial lung disease 1 | 292
non-inflammatory breast cancer 1 | 208

Tissue

Blood and immune system 23 | 17,994
Cardiovascular System 23 | 17,957
Digestive Tract 23 | 18,472
Endocrine System 23 | 18,511
Female tissues 23 | 18,646
Liver and Pancreas 23 | 18,135
Male tissues 23 | 17,968
Nervous System 23 | 18,560
Respiratory system 23 | 17,483
Skin and soft tissues 23 | 18,114
Urinary Tract 23 | 18,443

Target Family

Non-IDG 13 | 11,969
Enzyme 6 | 4,146
Kinase 2 | 634
GPCR 1 | 408
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase Praja-2 PJA2 Tbio Enzyme -0.64427 2.59 159
14-3-3 protein zeta/delta YWHAZ Tbio Non-IDG -2.55872 362.3 648
Vacuolar protein sorting-associated protein 4A VPS4A Tbio Non-IDG -1.67405 50.4 78
Ephrin type-A receptor 6 EPHA6 Tchem Kinase -1.33373 29.2 223
Ribonuclease pancreatic RNASE1 Tchem Enzyme -2.52706 314.3 173
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.90606 962.2 580
Atrophin-1 ATN1 Tbio Non-IDG -2.40264 232.0 102
VEGF coregulated chemokine 1 CXCL17 Tbio Non-IDG -1.15371 14.4 39
TLD domain-containing protein 1 TLDC1 Tdark Non-IDG 0.00000 110
Cyclin-dependent kinase 9 CDK9 Tchem Kinase -2.89065 712.3 354