Development Level

Tbio 35 | 11,651
Tdark 8 | 6,593
Tchem 6 | 1,388
Tclin 1 | 612

Collection

GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

abnormal skin morphology 50 | 50
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

ovarian cancer 33 | 8,520
Carcinoma 28 | 11,493
psoriasis 23 | 6,694
lung cancer 22 | 4,740
osteosarcoma 19 | 7,950
interstitial cystitis 17 | 2,312
medulloblastoma, large-cell 17 | 6,241
Breast cancer 16 | 3,578
glioblastoma 16 | 5,792
ependymoma 14 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
atypical teratoid / rhabdoid tumor 13 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
Astrocytoma, Pilocytic 12 | 3,081
group 3 medulloblastoma 12 | 4,104
lung carcinoma 12 | 2,843
non-small cell lung cancer 12 | 2,890
adult high grade glioma 11 | 3,801
invasive ductal carcinoma 11 | 2,951
lung adenocarcinoma 11 | 2,716
oligodendroglioma 10 | 2,850
Cancer 9 | 2,499
astrocytic glioma 9 | 2,597
malignant mesothelioma 9 | 3,232
Pick disease 8 | 1,894
adrenocortical carcinoma 8 | 1,428
breast carcinoma 8 | 1,638
group 4 medulloblastoma 8 | 1,855
pancreatic cancer 8 | 2,398
primitive neuroectodermal tumor 8 | 3,035
Kidney cancer 7 | 2,613
Rheumatoid arthritis 7 | 1,191
pituitary cancer 7 | 1,972
subependymal giant cell astrocytoma 7 | 2,287
ulcerative colitis 7 | 1,819
Autosomal recessive predisposition 6 | 1,442
acute quadriplegic myopathy 6 | 1,158
colon cancer 6 | 1,478
cystic fibrosis 6 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
spina bifida 6 | 1,074
tuberculosis 6 | 2,010
Multiple myeloma 5 | 1,332
diabetes mellitus 5 | 1,728
ductal carcinoma in situ 5 | 1,745
nasopharyngeal carcinoma 5 | 1,058
non primary Sjogren syndrome sicca 5 | 891
chronic lymphosyte leukemia 4 | 204
cutaneous lupus erythematosus 4 | 1,057
juvenile dermatomyositis 4 | 1,187
primary pancreatic ductal adenocarcinoma 4 | 1,109
urothelial carcinoma 4 | 318
Anemia 3 | 365
Bipolar Disorder 3 | 666
Chronic Lymphocytic Leukemia 3 | 262
Melanoma 3 | 711
Neurodegenerative disease 3 | 414
Obesity 3 | 678
Parkinson's disease 3 | 392
Peripheral Neuropathy 3 | 134
Prenatal onset 3 | 139
acute myeloid leukemia 3 | 783
astrocytoma 3 | 1,146
atypical teratoid/rhabdoid tumor 3 | 357
fibroadenoma 3 | 559
gastric cancer 3 | 459
hepatocellular carcinoma 3 | 547
medulloblastoma 3 | 720
primary Sjogren syndrome 3 | 735
tuberculosis and treatment for 6 months 3 | 409
Absent reflex 2 | 92
Absent tendon reflex 2 | 92
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Arthritis 2 | 290
Atopic dermatitis 2 | 952
Curvature of spine 2 | 282
Distal muscle weakness 2 | 62
Down syndrome 2 | 499
Endometriosis 2 | 540
Epilepsy 2 | 792
Hypersensitivity reaction type II disease 2 | 253
Hypertension 2 | 396
Liver cancer 2 | 604
Liver neoplasms 2 | 130
Lung disease 2 | 142
Movement Disorders 2 | 55
Neuropathy 2 | 261
Proteinuria 2 | 144
Reflex, Deep Tendon, Absent 2 | 92
Strabismus 2 | 270
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
esophageal adenocarcinoma 2 | 737
head and neck cancer 2 | 271
mucosa-associated lymphoid tissue lymphoma 2 | 484
pancreatic carcinoma 2 | 562
pterygium 2 | 76

Tissue

Endocrine System 50 | 18,159
Digestive Tract 49 | 17,369
Female tissues 49 | 17,400
Liver and Pancreas 49 | 16,750
Male tissues 49 | 17,142
Skin and soft tissues 49 | 17,230
Urinary Tract 49 | 16,678
Nervous System 48 | 16,725
Respiratory system 48 | 16,393
Blood and immune system 47 | 16,909
Cardiovascular System 45 | 15,192

Target Family

Non-IDG 25 | 12,091
Enzyme 14 | 4,145
GPCR 3 | 408
Kinase 3 | 634
Transcription Factor 2 | 1,400
Epigenetic 1 | 242
Ion Channel 1 | 344
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
Ephrin type-A receptor 6 EPHA6 Tchem Kinase -1.34848 21.8 266
Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 CHCHD7 Tdark Non-IDG -1.37776 18.2 39
Laminin subunit beta-3 LAMB3 Tbio Non-IDG -2.07156 116.4 170
Ly6/PLAUR domain-containing protein 6 LYPD6 Tbio Non-IDG -0.61559 4.87 35
Protein fosB FOSB Tbio Transcription Factor -2.66286 432.2 328
Cytoplasmic protein NCK1 NCK1 Tbio Non-IDG -2.25032 186.5 398
Vacuolar protein sorting-associated protein 4A VPS4A Tbio Non-IDG -1.69610 49.5 94
Putative homeodomain transcription factor 1 PHTF1 Tdark Non-IDG -1.09131 13.1 25
14-3-3 protein zeta/delta YWHAZ Tbio Non-IDG -2.59435 390.4 689