Development Level

Tbio 11 | 11,445
Tdark 3 | 6,588
Tclin 2 | 613
Tchem 1 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

abnormal maxilla morphology 17 | 17
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 15 | 11,493
glioblastoma 10 | 5,792
osteosarcoma 10 | 7,950
atypical teratoid / rhabdoid tumor 9 | 5,112
medulloblastoma, large-cell 9 | 6,241
Kidney cancer 8 | 2,613
ovarian cancer 8 | 8,520
psoriasis 8 | 6,694
lung cancer 7 | 4,740
ependymoma 5 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
pediatric high grade glioma 5 | 1,064
primitive neuroectodermal tumor 5 | 3,035
Breast cancer 4 | 3,578
cystic fibrosis 4 | 1,696
group 3 medulloblastoma 4 | 4,104
Astrocytoma, Pilocytic 3 | 3,081
Obesity 3 | 678
Waldenstrons macroglobulinemia 3 | 765
astrocytic glioma 3 | 2,597
diabetes mellitus 3 | 1,728
esophageal adenocarcinoma 3 | 737
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
invasive ductal carcinoma 3 | 2,951
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
subependymal giant cell astrocytoma 3 | 2,287
Atopic dermatitis 2 | 952
Dull intelligence 2 | 645
Ichthyosis 2 | 56
Intellectual disability 2 | 1,016
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Poor school performance 2 | 645
Prostatic Neoplasms 2 | 495
Schizophrenia 2 | 1,160
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
ductal carcinoma in situ 2 | 1,745
mucosa-associated lymphoid tissue lymphoma 2 | 484
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
3-methylglutaconic aciduria 1 | 29
Abnormality of blood and blood-forming tissues 1 | 10
Abnormality of the haematopoietic system 1 | 10
Acquired scoliosis 1 | 281
Alopecia 1 | 115
Alzheimer Disease 1 | 83
Anemia 1 | 365
Atherosclerosis 1 | 291
Blepharophimosis 1 | 70
Brachycephaly 1 | 88
Broad cranium shape 1 | 88
Coffin-Siris syndrome 1 | 17
Concave bridge of nose 1 | 195
Congenital small ears 1 | 48
Corneal disease 1 | 31
Delayed speech and language development 1 | 112
Dementia 1 | 175
Depressed nasal bridge 1 | 195
Depressed nasal root/bridge 1 | 195
Essential Hypertension 1 | 94
HIV Infections 1 | 102
Hematological Disease 1 | 18
Hyperinsulinism 1 | 133
Language Delay 1 | 112
Liver Cirrhosis, Experimental 1 | 769
Liver cancer 1 | 604
Lupus erythematosus 1 | 57
MITOCHONDRIAL COMPLEX V (ATP SYNTHASE) DEFICIENCY, NUCLEAR TYPE 1 1 | 2
Microphthalmia with limb anomalies 1 | 40
Morphine dependence 1 | 16
Muscle Weakness 1 | 170
Myocardial Infarction 1 | 151
Myopathy 1 | 185
Neurodevelopmental Disorders 1 | 70
Parkinson's disease 1 | 392
Penile hypospadias 1 | 106
Peripheral vascular disease 1 | 87
Ptosis 1 | 48
Sensorineural Hearing Loss (disorder) 1 | 284
Speech Delay 1 | 112
Speech impairment 1 | 112
Thin upper lip vermilion 1 | 67
Upward slant of palpebral fissure 1 | 75
Wide skull shape 1 | 88
active Crohn's disease 1 | 922
active ulcerative colitis 1 | 764
facioscapulohumeral dystrophy 1 | 288
interstitial lung disease 1 | 298
posterior fossa group A ependymoma 1 | 468
sarcoidosis 1 | 370

Tissue

Blood and immune system 17 | 16,909
Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Female tissues 17 | 17,400
Liver and Pancreas 17 | 16,750
Male tissues 17 | 17,142
Nervous System 17 | 16,725
Skin and soft tissues 17 | 17,230
Urinary Tract 17 | 16,678
Cardiovascular System 16 | 15,192
Respiratory system 16 | 16,393

Target Family

Non-IDG 7 | 12,091
Enzyme 5 | 4,145
Epigenetic 2 | 242
Kinase 2 | 634
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Insulin-degrading enzyme IDE Tchem Enzyme -2.57779 392.8 331
Putative sodium-coupled neutral amino acid transporter 10 SLC38A10 Tdark Transporter -0.27712 1.71 25
Leucine-rich repeat serine/threonine-protein kinase 1 LRRK1 Tbio Kinase -1.33128 18.1 134
Epidermal growth factor receptor kinase substrate 8-like protein 3 EPS8L3 Tdark Enzyme -0.23449 1.72 101
Tetratricopeptide repeat protein 28 TTC28 Tdark Non-IDG -0.50526 3.76 3
Chromodomain-helicase-DNA-binding protein 1 CHD1 Tbio Epigenetic -2.14472 148.3 122
Cysteine-rich protein 2-binding protein KAT14 Tbio Non-IDG -0.90082 7.81 111
Nischarin NISCH Tclin Non-IDG -2.81317 622.8 49
SET domain-containing protein 5 SETD5 Tbio Epigenetic -0.91515 9.39 43
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 ABHD5 Tbio Enzyme -1.95524 94.8 243