Development Level

Tbio 13 | 11,445
Tdark 3 | 6,588
Tchem 1 | 1,598

Collection

GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

abnormal liver morphology 17 | 17
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

psoriasis 10 | 6,694
osteosarcoma 9 | 7,950
Carcinoma 8 | 11,493
ovarian cancer 8 | 8,520
group 3 medulloblastoma 6 | 4,104
Cancer 5 | 2,499
atypical teratoid / rhabdoid tumor 5 | 5,112
invasive ductal carcinoma 5 | 2,951
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
medulloblastoma, large-cell 5 | 6,241
Kidney cancer 4 | 2,613
Breast cancer 3 | 3,578
adrenocortical carcinoma 3 | 1,428
cystic fibrosis 3 | 1,696
glioblastoma 3 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung adenocarcinoma 3 | 2,716
lung cancer 3 | 4,740
non-small cell lung cancer 3 | 2,890
pituitary cancer 3 | 1,972
Schizophrenia 2 | 1,160
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
adult high grade glioma 2 | 3,801
breast carcinoma 2 | 1,638
esophageal adenocarcinoma 2 | 737
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
non primary Sjogren syndrome sicca 2 | 891
posterior fossa group A ependymoma 2 | 468
spina bifida 2 | 1,074
subependymal giant cell astrocytoma 2 | 2,287
Abnormal color vision 1 | 31
Abnormal skeletal development 1 | 60
Abnormality of the metaphyses 1 | 48
Abnormality of the ribs 1 | 32
Abnormally-shaped vertebrae 1 | 31
Acrocephaly 1 | 12
Big calvaria 1 | 147
Blue sclera 1 | 32
Breast Neoplasms 1 | 445
Cataract 7 1 | 32
Clouston syndrome 1 | 9
Color vision defect 1 | 33
Color vision defect, severe 1 | 31
Communicating Hydrocephalus 1 | 8
Coronal craniosynostosis 1 | 14
Decreased projection of midface 1 | 105
Defective tooth enamel 1 | 31
Dentinogenesis imperfecta 1 | 25
Diabetic Angiopathies 1 | 16
Diabetic retinopathy 1 | 56
Downward slant of palpebral fissure 1 | 158
Dystrophic tooth enamel 1 | 31
Enamel abnormalities 1 | 31
Entropion 1 | 22
Fibrosis 1 | 44
Frequent fractures 1 | 53
Generalized osteopenia 1 | 99
Gestational diabetes 1 | 26
Glomerulonephritis 1 | 46
Histoplasmosis 1 | 13
Human immunodeficiency virus infectious disease 1 | 138
Hyperkyphosis 1 | 111
Hypotrophic midface 1 | 105
Immunologic Deficiency Syndromes 1 | 113
Increased fracture rate 1 | 53
Increased size of cranium 1 | 147
Kyphosis deformity of spine 1 | 114
Late tooth eruption 1 | 61
Lymphopenia 1 | 67
MEDNIK syndrome 1 | 8
Mammary Neoplasms 1 | 425
Microretrognathia 1 | 13
Midface retrusion 1 | 105
Nonsyndromic deafness 1 | 142
Oculodentodigital dysplasia 1 | 14
Osteogenesis imperfecta 1 | 34
Osteopenia 1 | 99
Palmoplantar keratosis 1 | 74
Photodysphoria 1 | 121
Photophobia 1 | 121
Pre-Eclampsia 1 | 68
Progressive multifocal leukoencephalopathy 1 | 25
Recurrent otitis media 1 | 42
Recurrent sinus disease 1 | 22
Recurrent sinusitis 1 | 22
Sensorineural hearing loss 1 | 106
Skin disease 1 | 66
Small midface 1 | 105
Sporotrichosis 1 | 10
Synostotic Posterior Plagiocephaly 1 | 8
Testicular cancer 1 | 25
Vaccinia 1 | 36
Varying degree of multiple fractures 1 | 53
X-linked cerebral adrenoleukodystrophy 1 | 116
cone-rod dystrophy 1 | 59
head and neck cancer and chronic obstructive pulmonary disease 1 | 239

Tissue

Blood and immune system 17 | 16,909
Endocrine System 17 | 18,159
Female tissues 17 | 17,400
Skin and soft tissues 17 | 17,230
Digestive Tract 16 | 17,369
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Respiratory system 16 | 16,393
Urinary Tract 16 | 16,678
Cardiovascular System 15 | 15,192
Nervous System 15 | 16,725

Target Family

Non-IDG 11 | 12,091
Enzyme 4 | 4,145
GPCR 2 | 408

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Relaxin receptor 2 RXFP2 Tbio GPCR -1.97913 85.3 207
Zinc finger CCCH-type antiviral protein 1-like ZC3HAV1L Tdark Non-IDG 0.30 0.50 66
Activity-dependent neuroprotector homeobox protein 2 ADNP2 Tdark Non-IDG -0.53148 2.71 58
Proline-serine-threonine phosphatase-interacting protein 2 PSTPIP2 Tbio Enzyme -0.96460 10.4 54
Follistatin-related protein 3 FSTL3 Tbio Non-IDG -1.80964 76.6 138
Embigin EMB Tbio Non-IDG -2.79800 638.6 103
Allograft inflammatory factor 1-like AIF1L Tdark Non-IDG -1.33601 20.8 16
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 HDDC3 Tbio Enzyme -0.98677 9.84 86
E3 ubiquitin-protein ligase UBR2 UBR2 Tbio Enzyme -1.32729 22.3 158