Development Level

Tbio 17 | 11,445
Tchem 3 | 1,598
Tdark 2 | 6,588
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

abnormal joint morphology 23 | 23
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 15 | 11,493
ovarian cancer 13 | 8,520
glioblastoma 12 | 5,792
osteosarcoma 12 | 7,950
psoriasis 12 | 6,694
ependymoma 9 | 4,679
medulloblastoma, large-cell 8 | 6,241
Astrocytoma, Pilocytic 7 | 3,081
adult high grade glioma 7 | 3,801
atypical teratoid / rhabdoid tumor 7 | 5,112
lung cancer 7 | 4,740
Pick disease 6 | 1,894
group 3 medulloblastoma 6 | 4,104
malignant mesothelioma 6 | 3,232
Kidney cancer 5 | 2,613
invasive ductal carcinoma 5 | 2,951
juvenile dermatomyositis 5 | 1,187
lung carcinoma 5 | 2,843
pituitary cancer 5 | 1,972
primitive neuroectodermal tumor 5 | 3,035
tuberculosis 5 | 2,010
Breast cancer 4 | 3,578
acute quadriplegic myopathy 4 | 1,158
adrenocortical carcinoma 4 | 1,428
cystic fibrosis 4 | 1,696
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Atopic dermatitis 3 | 952
Autosomal recessive predisposition 3 | 1,442
Frontal bossing 3 | 157
Genu varum 3 | 29
Hypoplastic mandible condyle 3 | 275
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Short stature 3 | 531
aldosterone-producing adenoma 3 | 665
ductal carcinoma in situ 3 | 1,745
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung adenocarcinoma 3 | 2,716
pediatric high grade glioma 3 | 1,064
sonic hedgehog group medulloblastoma 3 | 467
ulcerative colitis 3 | 1,819
Alkaline phosphatase serum increased 2 | 29
Amyotrophic lateral sclerosis 2 | 451
Arthralgia 2 | 90
Bone pain 2 | 42
Cataract 2 | 297
Cleft Palate 2 | 271
Degenerative polyarthritis 2 | 115
Failure to gain weight 2 | 365
Femoral bowing 2 | 20
Fetal Growth Retardation 2 | 189
Fibular bowing 2 | 5
Hyperparathyroidism 2 | 48
Hyperphosphatemia 2 | 32
Hypophosphatemia 2 | 40
Increased serum parathyroid hormone 2 | 14
Infant, Small for Gestational Age 2 | 176
Intellectual disability 2 | 1,016
Intrauterine retardation 2 | 176
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Macrotia 2 | 87
Melanoma 2 | 711
Metaphyseal irregularity 2 | 23
Motor delay 2 | 147
Multiple myeloma 2 | 1,332
Muscle hypotonia 2 | 571
No development of motor milestones 2 | 147
Orbital separation excessive 2 | 244
Osteomalacia 2 | 35
Pediatric failure to thrive 2 | 365
Pilocytic astrocytoma 2 | 56
Rickets 2 | 49
Sensorineural Hearing Loss (disorder) 2 | 284
Tibial bowing 2 | 19
Uranostaphyloschisis 2 | 167
active Crohn's disease 2 | 922
astrocytic glioma 2 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
gastric carcinoma 2 | 807
nasopharyngeal carcinoma 2 | 1,058
non-small cell lung cancer 2 | 2,890
pancreatic cancer 2 | 2,398
progressive supranuclear palsy 2 | 676
Beading of ribs 1 | 6
Compression of spinal cord 1 | 10
Enthesitis 1 | 3
Hypophosphatemic Rickets 1 | 11
Hypophosphatemic Rickets, X-Linked Dominant 1 | 1

Tissue

Blood and immune system 23 | 16,909
Digestive Tract 23 | 17,369
Endocrine System 23 | 18,159
Female tissues 23 | 17,400
Liver and Pancreas 23 | 16,750
Male tissues 23 | 17,142
Skin and soft tissues 23 | 17,230
Urinary Tract 23 | 16,678
Respiratory system 22 | 16,393
Nervous System 21 | 16,725
Cardiovascular System 19 | 15,192

Target Family

Non-IDG 11 | 12,091
Enzyme 8 | 4,145
Kinase 2 | 634
Ion Channel 1 | 344
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-19 RAB19 Tdark Enzyme -0.54731 3.31 75
Centromere protein J CENPJ Tbio Non-IDG -1.79588 59.0 102
Acetylcholine receptor subunit alpha CHRNA1 Tclin Ion Channel -1.66400 41.7 307
Pleckstrin homology domain-containing family G member 3 PLEKHG3 Tdark Non-IDG -0.40654 2.48 66
BTB/POZ domain-containing protein KCTD15 KCTD15 Tbio Non-IDG -1.04860 11.7 176
Complement C1r subcomponent-like protein C1RL Tbio Enzyme -0.57210 4.61 83
Phosphatidylserine synthase 1 PTDSS1 Tbio Enzyme -1.93971 87.1 109
Synaptopodin-2 SYNPO2 Tbio Non-IDG -1.31714 27.9 42
Leucine-rich repeat serine/threonine-protein kinase 1 LRRK1 Tbio Kinase -1.33128 18.1 134
Protein YIPF5 YIPF5 Tbio Non-IDG -1.27388 17.9 90