Development Level

Tbio 10 | 11,651
Tdark 4 | 6,593
Tchem 2 | 1,388

IMPC Phenotype

abnormal heart left ventricle ... 16 | 16
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

ovarian cancer 10 | 8,520
Carcinoma 7 | 11,493
osteosarcoma 7 | 7,950
atypical teratoid / rhabdoid tumor 5 | 5,112
group 3 medulloblastoma 5 | 4,104
medulloblastoma, large-cell 5 | 6,241
invasive ductal carcinoma 4 | 2,951
primitive neuroectodermal tumor 4 | 3,035
ulcerative colitis 4 | 1,819
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
ductal carcinoma in situ 3 | 1,745
ependymoma 3 | 4,679
glioblastoma 3 | 5,792
lung cancer 3 | 4,740
lung carcinoma 3 | 2,843
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
pituitary cancer 3 | 1,972
tuberculosis 3 | 2,010
African trypanosomiasis 2 | 5
Alzheimer's disease 2 | 658
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
Breast cancer 2 | 3,578
Obesity 2 | 678
Pick disease 2 | 1,894
Prostatic Neoplasms 2 | 495
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
astrocytoma 2 | 1,146
diabetes mellitus 2 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
non-small cell lung cancer 2 | 2,890
primary pancreatic ductal adenocarcinoma 2 | 1,109
psoriasis 2 | 6,694
spina bifida 2 | 1,074
Acquired immunodeficiency syndrome 1 | 197
Acquired metabolic disease 1 | 336
Acute kidney injury 1 | 70
Astigmatism 1 | 54
Atherosclerosis 1 | 291
Autistic Disorder 1 | 364
Autoimmune Diseases 1 | 67
Barrett's esophagus 1 | 182
Brain infarction 1 | 22
Breast Neoplasms 1 | 445
Cardiomegaly 1 | 116
Cardiomyopathy 1 | 116
Cardiovascular system disease 1 | 246
Ciliopathy 1 | 71
Colitis 1 | 54
Combined oxidative phosphorylation deficiency 1 | 14
Cone dystrophy 1 | 71
Diabetes Mellitus, Experimental 1 | 108
Fatty Liver 1 | 70
Fatty liver disease 1 | 103
Fibrosis 1 | 44
Fundus dystrophy 1 | 83
Glucose Intolerance 1 | 19
HIV Infections 1 | 102
Heart disease 1 | 306
Heart failure 1 | 162
Hemolytic anemia 1 | 77
Huntington's disease 1 | 76
Hypertension 1 | 396
Impaired glucose tolerance 1 | 28
Insulin Resistance 1 | 72
Kidney disease 1 | 430
Leukodystrophy 1 | 55
Liver Cirrhosis, Experimental 1 | 769
Mammary Neoplasms 1 | 425
Metabolic syndrome X 1 | 52
Mitral valve insufficiency 1 | 49
Mood Disorders 1 | 184
Multiple Sclerosis 1 | 540
Myopia 1 | 176
Myositis 1 | 30
Neoplasm Metastasis 1 | 168
Nerve Degeneration 1 | 121
Neurodegenerative Disorders 1 | 79
Neurodevelopmental Disorders 1 | 70
Non-alcoholic Fatty Liver Disease 1 | 42
Osteoarthritis 1 | 184
Paralysed 1 | 42
Paralysis 1 | 9
Parkinson's disease 1 | 392
Peripapillary chorioretinal atrophy 1 | 2
Pneumonia 1 | 174
Premature ovarian failure 1 | 65
Retinal Diseases 1 | 55
Slow progression 1 | 89
Systemic scleroderma 1 | 60
Toxic encephalopathy 1 | 141
West Nile encephalitis 1 | 9
chronic kidney disease 1 | 90
hereditary spastic paraplegia 1 | 318
interstitial lung disease 1 | 298
posterior fossa group B ependymoma 1 | 416

Tissue

Blood and immune system 16 | 16,909
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678
Cardiovascular System 15 | 15,192

Target Family

Non-IDG 8 | 12,091
Enzyme 5 | 4,145
Epigenetic 1 | 242
TF/Epigenetic 1 | 38
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Yae1 domain-containing protein 1 YAE1D1 Tdark Non-IDG 0.26 0.54 89
Protein phosphatase 1 regulatory subunit 14D PPP1R14D Tdark Enzyme -0.85532 7.69 40
Transcriptional enhancer factor TEF-1 TEAD1 Tbio Transcription Factor -1.71108 45.2 164
PR domain zinc finger protein 4 PRDM4 Tbio TF/Epigenetic -0.87918 7.84 221
NAD-dependent protein deacetylase sirtuin-1 SIRT1 Tchem Epigenetic -3.50639 3413.7 733
Deoxyribonuclease-1-like 2 DNASE1L2 Tbio Enzyme -1.67313 48.8 23
Kelch-like protein 29 KLHL29 Tbio Non-IDG 0.10 0.65 61
Protein WFDC11 WFDC11 Tdark Non-IDG 0.30 0.25 11
E3 ubiquitin-protein ligase RNF144B RNF144B Tbio Enzyme -1.43635 26.6 245
Ubiquitin-fold modifier-conjugating enzyme 1 UFC1 Tbio Non-IDG -1.03169 9.11 165