Development Level

Tbio 51 | 11,651
Tclin 7 | 612
Tdark 6 | 6,593
Tchem 5 | 1,388

Collection

RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

abnormal gait 69 | 69
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 41 | 11,493
psoriasis 38 | 6,694
osteosarcoma 37 | 7,950
glioblastoma 35 | 5,792
atypical teratoid / rhabdoid tumor 31 | 5,112
ovarian cancer 31 | 8,520
medulloblastoma, large-cell 30 | 6,241
ependymoma 25 | 4,679
lung cancer 22 | 4,740
adult high grade glioma 21 | 3,801
Astrocytoma, Pilocytic 20 | 3,081
group 3 medulloblastoma 19 | 4,104
primitive neuroectodermal tumor 19 | 3,035
lung carcinoma 18 | 2,843
oligodendroglioma 18 | 2,850
Breast cancer 16 | 3,578
astrocytic glioma 15 | 2,597
Cancer 14 | 2,499
Kidney cancer 14 | 2,613
group 4 medulloblastoma 14 | 1,855
invasive ductal carcinoma 13 | 2,951
Autosomal recessive predisposition 12 | 1,442
non-small cell lung cancer 12 | 2,890
pancreatic cancer 12 | 2,398
diabetes mellitus 11 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
lung adenocarcinoma 11 | 2,716
tuberculosis 11 | 2,010
ductal carcinoma in situ 10 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
malignant mesothelioma 10 | 3,232
Pick disease 9 | 1,894
esophageal adenocarcinoma 9 | 737
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
pituitary cancer 9 | 1,972
Melanoma 8 | 711
colon cancer 8 | 1,478
cystic fibrosis 8 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
subependymal giant cell astrocytoma 8 | 2,287
Atopic dermatitis 7 | 952
Epilepsy 7 | 792
Intellectual disability 7 | 1,016
Neurodegenerative disease 7 | 414
Obesity 7 | 678
Schizophrenia 7 | 1,160
adrenocortical carcinoma 7 | 1,428
breast carcinoma 7 | 1,638
Multiple myeloma 6 | 1,332
astrocytoma 6 | 1,146
cutaneous lupus erythematosus 6 | 1,057
dermatomyositis 6 | 966
fibroadenoma 6 | 559
gastric carcinoma 6 | 807
Alzheimer's disease 5 | 658
Bipolar Disorder 5 | 666
Cleft Palate 5 | 271
Hypertension 5 | 396
Muscle hypotonia 5 | 571
Rheumatoid arthritis 5 | 1,191
aldosterone-producing adenoma 5 | 665
juvenile dermatomyositis 5 | 1,187
pediatric high grade glioma 5 | 1,064
Absent reflex 4 | 92
Absent tendon reflex 4 | 92
Acquired metabolic disease 4 | 336
Cognitive delay 4 | 608
Gait abnormality 4 | 135
Gaucher disease type 1 4 | 180
Global developmental delay 4 | 608
Hypertensive disease 4 | 292
Mental and motor retardation 4 | 608
Neuropathy 4 | 261
Reflex, Deep Tendon, Absent 4 | 92
Short stature 4 | 531
Skin cancer 4 | 469
active ulcerative colitis 4 | 764
hearing impairment 4 | 199
pancreatic carcinoma 4 | 562
primary Sjogren syndrome 4 | 735
ulcerative colitis 4 | 1,819
Acquired scoliosis 3 | 281
Chronic Lymphocytic Leukemia 3 | 262
Curvature of spine 3 | 282
Decreased tendon reflex 3 | 122
Distal limb muscle weakness due to peripheral neuropathy 3 | 62
Distal muscle weakness 3 | 62
Hepatomegaly 3 | 285
Infantile onset 3 | 238
Inflammatory bowel disease 3 | 151
Multiple Sclerosis 3 | 540
Progressive disorder 3 | 142
Prostatic Neoplasms 3 | 495
Vascular disease 3 | 319
Waldenstrons macroglobulinemia 3 | 765
mucosa-associated lymphoid tissue lymphoma 3 | 484
primary pancreatic ductal adenocarcinoma 3 | 1,109
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074

Tissue

Endocrine System 68 | 18,159
Skin and soft tissues 68 | 17,230
Digestive Tract 66 | 17,369
Female tissues 66 | 17,400
Blood and immune system 65 | 16,909
Liver and Pancreas 65 | 16,750
Male tissues 65 | 17,142
Urinary Tract 65 | 16,678
Nervous System 63 | 16,725
Cardiovascular System 61 | 15,192
Respiratory system 61 | 16,393

Target Family

Non-IDG 39 | 12,091
Enzyme 9 | 4,145
Transcription Factor 5 | 1,400
Ion Channel 4 | 344
Kinase 4 | 634
Epigenetic 2 | 242
GPCR 2 | 408
TF/Epigenetic 2 | 38
Nuclear Receptor 1 | 48
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Macrophage receptor MARCO MARCO Tbio Non-IDG -2.37206 210.3 189
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial SIRT4 Tbio Epigenetic -2.14139 133.9 254
BRISC and BRCA1-A complex member 2 BABAM2 Tbio Non-IDG -1.84649 70.2 156
Inositol monophosphatase 3 IMPAD1 Tdark Enzyme -0.78606 4.97 79
Vasculin GPBP1 Tdark Non-IDG -0.50909 2.70 62
RCC1 domain-containing protein 1 RCCD1 Tdark Non-IDG -0.97968 9.71 12
Short transient receptor potential channel 3 TRPC3 Tchem Ion Channel -2.46704 294.6 217
Ubiquitin-conjugating enzyme E2 B UBE2B Tbio Non-IDG -1.56328 38.9 167
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 PLCZ1 Tbio Enzyme -2.11922 137.6 85
Death-associated protein kinase 1 DAPK1 Tchem Kinase -2.34153 226.1 276