Development Level

Tbio 1 | 11,445
Tchem 1 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

abnormal fibula morphology 2 | 2
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 2 | 11,493
glioblastoma 2 | 5,792
medulloblastoma, large-cell 2 | 6,241
osteosarcoma 2 | 7,950
'Bulging' epiphyses 1 | 3
'Bulging' of the costochondral junction 1 | 2
Abdominal wall muscle weakness 1 | 6
Addison's disease 1 | 31
Alkaline phosphatase serum increased 1 | 29
Alopecia 1 | 115
Autosomal recessive predisposition 1 | 1,442
Bone pain 1 | 42
Cancer 1 | 2,499
Corneal disease 1 | 31
Defective enamel matrix 1 | 35
Deformed rib cage 1 | 2
Delayed epiphyseal ossification 1 | 10
Delayed maturation of end part of long bone 1 | 10
Dental Enamel Hypoplasia 1 | 43
Difficulty standing 1 | 3
Difficulty walking 1 | 28
Dysplasia of tooth enamel 1 | 35
Enlargement of the ankles 1 | 3
Enlargement of the costochondral junction 1 | 4
Enlargement of the wrists 1 | 5
Failure to gain weight 1 | 365
Femoral bowing 1 | 20
Fibular bowing 1 | 5
Flat back of the head 1 | 26
Flat occiput 1 | 26
Frequent fractures 1 | 53
Frontal bossing 1 | 157
Generalized aminoaciduria 1 | 9
Genu varum 1 | 29
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hypercalcemia 1 | 59
Hyperparathyroidism 1 | 48
Hyperparathyroidism, Secondary 1 | 7
Hyperphosphatemia 1 | 32
Hypervitaminosis D 1 | 8
Hypocalcaemic seizure 1 | 4
Hypocalcemic vitamin D-dependent rickets 1 | 2
Hypophosphatemia 1 | 40
Increased fracture rate 1 | 53
Increased serum parathyroid hormone 1 | 14
Irritation - emotion 1 | 68
Kidney cancer 1 | 2,613
Late tooth eruption 1 | 61
Metaphyseal dysplasia 1 | 11
Metaphyseal irregularity 1 | 23
Motor delay 1 | 147
Multiple Sclerosis 1 | 540
Muscle hypotonia 1 | 571
No development of motor milestones 1 | 147
Nonorganic psychosis 1 | 84
Osteomalacia 1 | 35
Osteopetrosis 1 | 43
Parkinson's disease 1 | 392
Pediatric failure to thrive 1 | 365
Polymyositis 1 | 5
Poor growth 1 | 114
Protuberant abdomen 1 | 16
Psychotic Disorders 1 | 151
Rickets 1 | 49
Sick sinus syndrome 1 | 15
Sparse bone trabeculae 1 | 3
Subperiosteal erosions due to secondary hyperparathyroidism 1 | 2
Thin bony cortex 1 | 9
Thin dental enamel 1 | 35
Tibial bowing 1 | 19
Varying degree of multiple fractures 1 | 53
Very poor growth 1 | 114
Vitamin D Hydroxylation-Deficient Rickets, Type 1A 1 | 1
Vitamin D-dependent rickets, type 1 1 | 2
Widely patent fontanels and sutures 1 | 12
adult high grade glioma 1 | 3,801
atypical teratoid / rhabdoid tumor 1 | 5,112
cystic fibrosis 1 | 1,696
group 4 medulloblastoma 1 | 1,855
invasive ductal carcinoma 1 | 2,951
lung carcinoma 1 | 2,843
malignant mesothelioma 1 | 3,232
nephrosclerosis 1 | 333
non-small cell lung cancer 1 | 2,890
primitive neuroectodermal tumor 1 | 3,035
psoriasis 1 | 6,694

Tissue

Blood and immune system 2 | 16,909
Digestive Tract 2 | 17,369
Endocrine System 2 | 18,159
Female tissues 2 | 17,400
Liver and Pancreas 2 | 16,750
Male tissues 2 | 17,142
Nervous System 2 | 16,725
Respiratory system 2 | 16,393
Skin and soft tissues 2 | 17,230
Urinary Tract 2 | 16,678
Cardiovascular System 1 | 15,192

Target Family

Enzyme 1 | 4,145
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Leucine-rich repeat serine/threonine-protein kinase 1 LRRK1 Tbio Kinase -1.33128 18.1 134
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.70628 492.9 68