Development Level

Tbio 10 | 10,625
Tchem 2 | 1,890
Tclin 1 | 602
Tdark 1 | 7,003

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

abnormal femur morphology 14 | 14
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat-hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

osteosarcoma 11 | 7,933
glioblastoma 9 | 5,572
ovarian cancer 9 | 8,491
pilocytic astrocytoma 6 | 3,086
psoriasis 6 | 6,685
Pick disease 5 | 1,893
atypical teratoid / rhabdoid tumor 5 | 4,369
gastric carcinoma 4 | 832
invasive ductal carcinoma 4 | 2,950
juvenile dermatomyositis 4 | 1,189
medulloblastoma, large-cell 4 | 6,234
pituitary cancer 4 | 1,972
primitive neuroectodermal tumor 4 | 3,031
subependymal giant cell astrocytoma 4 | 2,287
Breast cancer 3 | 3,098
Cancer 3 | 2,346
Carcinoma 3 | 2,147
active Crohn's disease 3 | 918
colon cancer 3 | 1,475
diabetes mellitus 3 | 1,663
hereditary spastic paraplegia 3 | 313
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
lung cancer 3 | 4,473
malignant mesothelioma 3 | 3,163
non-small cell lung cancer 3 | 2,798
pediatric high grade glioma 3 | 2,712
posterior fossa group A ependymoma 3 | 1,511
primary pancreatic ductal adenocarcinoma 3 | 1,271
sonic hedgehog group medulloblastoma 3 | 1,482
Arthritis 2 | 248
Becker muscular dystrophy 2 | 187
Calcinosis 2 | 63
Central sleep apnea 2 | 12
Degenerative disc disease 2 | 28
Duchenne muscular dystrophy 2 | 602
Glaucoma 2 | 135
Heart valve disease 2 | 24
Hyperparathyroidism 2 | 43
Hyperphosphatemia 2 | 32
Hypophosphatemia 2 | 31
IGA Glomerulonephritis 2 | 454
Intellectual disability 2 | 573
Kidney disease 2 | 397
Microcephaly 2 | 149
Multiple Sclerosis 2 | 498
Neoplasm Invasiveness 2 | 127
Oral Submucous Fibrosis 2 | 18
Osteomalacia 2 | 28
Osteoporosis 2 | 259
Pulmonary Fibrosis 2 | 66
Rickets 2 | 42
Spontaneous abortion 2 | 108
Systemic scleroderma 2 | 66
Vascular disease 2 | 281
active ulcerative colitis 2 | 477
adult high grade glioma 2 | 2,148
chronic lymphosyte leukemia 2 | 232
cystic fibrosis 2 | 1,670
ductal carcinoma in situ 2 | 1,745
esophageal adenocarcinoma 2 | 737
group 3 medulloblastoma 2 | 2,254
group 4 medulloblastoma 2 | 1,875
head and neck cancer 2 | 270
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
limb girdle muscular dystrophy 2A 2 | 156
lung adenocarcinoma 2 | 2,714
lung carcinoma 2 | 2,844
nephrosclerosis 2 | 329
oligodendroglioma 2 | 2,849
pancreatic cancer 2 | 2,300
posterior fossa group B ependymoma 2 | 1,530
progressive supranuclear palsy 2 | 674
tuberculosis 2 | 1,563
tuberculosis and treatment for 6 months 2 | 686
ulcerative colitis 2 | 2,087
urothelial carcinoma 2 | 318
Agammaglobulinemia 1 | 24
Cardiomegaly 1 | 66
Diabetic Retinopathy 1 | 53
Female Urogenital Diseases 1 | 18
Gastrointestinal system disease 1 | 50
Goiter 1 | 27
Heart Diseases 1 | 42
Hepatolenticular Degeneration 1 | 24
Keratoconus 1 | 49
Obstructive sleep apnea 1 | 28
Osteochondritis dissecans 1 | 12
Osteogenesis imperfecta type III (disorder) 1 | 11
Osteogenesis imperfecta type IV (disorder) 1 | 10
Otosclerosis 1 | 13
Retinal disease 1 | 16
Scoliosis 1 | 40
Sick sinus syndrome 1 | 14
Sickle Cell Anemia 1 | 54
Stuttering 1 | 18
Type 1 diabetes mellitus 1 | 104
osteogenesis imperfecta type 3 1 | 11
osteogenesis imperfecta type 4 1 | 10

Tissue

Blood and immune system 14 | 17,994
Cardiovascular System 14 | 17,957
Digestive Tract 14 | 18,472
Endocrine System 14 | 18,511
Female tissues 14 | 18,646
Liver and Pancreas 14 | 18,135
Male tissues 14 | 17,968
Nervous System 14 | 18,560
Respiratory system 14 | 17,483
Skin and soft tissues 14 | 18,114
Urinary Tract 14 | 18,443

Target Family

Enzyme 5 | 4,146
Non-IDG 5 | 11,969
Kinase 2 | 634
Transcription Factor 1 | 1,400
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Metalloproteinase inhibitor 1 TIMP1 Tbio Enzyme -3.55219 3513.4 673
Prolyl 3-hydroxylase OGFOD1 OGFOD1 Tbio Enzyme -1.38307 23.9 91
Histone H2A deubiquitinase MYSM1 MYSM1 Tbio Transcription Factor -1.74299 57.5 175
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -3.98540 8801.0 1257
Collagen alpha-2(I) chain COL1A2 Tchem Non-IDG -2.61450 365.8 213
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.67102 464.3 66
Dual oxidase maturation factor 2 DUOXA2 Tbio Enzyme -1.29679 17.0 74
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 BNIP2 Tbio Non-IDG -1.53353 32.4 212
Leucine-rich repeat serine/threonine-protein kinase 1 LRRK1 Tbio Kinase -1.26990 15.7 92
Collagen alpha-2(IX) chain COL9A2 Tbio Non-IDG -1.57963 38.1 6