Development Level

Tbio 11 | 11,651
Tchem 1 | 1,388
Tclin 1 | 612
Tdark 1 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

abnormal femur morphology 14 | 14
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

osteosarcoma 11 | 7,950
Carcinoma 9 | 11,493
glioblastoma 9 | 5,792
ovarian cancer 9 | 8,520
Astrocytoma, Pilocytic 6 | 3,081
ependymoma 6 | 4,679
psoriasis 6 | 6,694
Kidney cancer 5 | 2,613
Pick disease 5 | 1,894
adult high grade glioma 5 | 3,801
atypical teratoid / rhabdoid tumor 5 | 5,112
Autosomal recessive predisposition 4 | 1,442
Short stature 4 | 531
gastric carcinoma 4 | 807
group 4 medulloblastoma 4 | 1,855
invasive ductal carcinoma 4 | 2,951
juvenile dermatomyositis 4 | 1,187
medulloblastoma, large-cell 4 | 6,241
pituitary cancer 4 | 1,972
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Breast cancer 3 | 3,578
Cancer 3 | 2,499
Degenerative polyarthritis 3 | 115
Frontal bossing 3 | 157
Genu varum 3 | 29
Tibial bowing 3 | 19
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
diabetes mellitus 3 | 1,728
group 3 medulloblastoma 3 | 4,104
hereditary spastic paraplegia 3 | 318
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung cancer 3 | 4,740
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
Abnormality of pelvic girdle bone morphology 2 | 37
Abortion, Spontaneous 2 | 109
Alkaline phosphatase serum increased 2 | 29
Aortic Valve Insufficiency 2 | 40
Arthralgia 2 | 90
Arthritis 2 | 290
Becker muscular dystrophy 2 | 191
Bone pain 2 | 42
Calcinosis 2 | 70
Duchenne muscular dystrophy 2 | 601
Frequent fractures 2 | 53
Glaucoma 2 | 239
Heart Valve Diseases 2 | 25
Heart disease 2 | 306
Heart valve disease 2 | 39
Hyperparathyroidism 2 | 48
Hyperphosphatemia 2 | 32
Hypertension 2 | 396
Hypophosphatemia 2 | 40
Hypoplastic mandible condyle 2 | 275
Hypotrophic malar bone 2 | 129
Increased fracture rate 2 | 53
Joint hyperflexibility 2 | 78
Kidney disease 2 | 430
Liver Cirrhosis, Experimental 2 | 769
Malar flattening 2 | 129
Microcephaly 2 | 166
Multiple Sclerosis 2 | 540
Neoplasm Invasiveness 2 | 161
Osteoarthritis 2 | 184
Osteomalacia 2 | 35
Osteopetrosis 2 | 43
Osteoporosis 2 | 363
Platyspondyly 2 | 56
Pulmonary Fibrosis 2 | 106
Relative short stature 2 | 13
Retinal disease 2 | 25
Rickets 2 | 49
Short stature, mild 2 | 13
Spontaneous abortion 2 | 113
Systemic scleroderma 2 | 60
Varying degree of multiple fractures 2 | 53
Vascular disease 2 | 319
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
ductal carcinoma in situ 2 | 1,745
esophageal adenocarcinoma 2 | 737
head and neck cancer 2 | 271
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
limb girdle muscular dystrophy 2A 2 | 213
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
nephrosclerosis 2 | 333
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676
tuberculosis 2 | 2,010
tuberculosis and treatment for 6 months 2 | 409
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 14 | 16,909
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Cardiovascular System 11 | 15,192

Target Family

Enzyme 5 | 4,145
Non-IDG 5 | 12,091
Kinase 2 | 634
Transcription Factor 1 | 1,400
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
AP-4 complex subunit epsilon-1 AP4E1 Tdark Non-IDG -0.66901 5.48 24
Metalloproteinase inhibitor 1 TIMP1 Tbio Enzyme -3.57247 3714.8 810
Phosphate-regulating neutral endopeptidase PHEX Tbio Enzyme -3.26526 1840.1 104
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.70628 492.9 68
Histone H2A deubiquitinase MYSM1 MYSM1 Tbio Transcription Factor -1.76987 62.1 184
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455
Collagen alpha-2(I) chain COL1A2 Tbio Non-IDG -2.64284 404.0 258
Dual oxidase maturation factor 2 DUOXA2 Tbio Enzyme -1.35199 19.7 84
Collagen alpha-2(IX) chain COL9A2 Tbio Non-IDG -1.59170 38.7 8
Centromere protein J CENPJ Tbio Non-IDG -1.79588 59.0 102