Development Level

Tbio 7 | 11,445

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

abnormal eyelid morphology 7 | 7
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 6 | 11,493
ovarian cancer 4 | 8,520
group 3 medulloblastoma 3 | 4,104
lung carcinoma 3 | 2,843
osteosarcoma 3 | 7,950
spina bifida 3 | 1,074
tuberculosis 3 | 2,010
Breast cancer 2 | 3,578
Multiple myeloma 2 | 1,332
atypical teratoid / rhabdoid tumor 2 | 5,112
cystic fibrosis 2 | 1,696
glioblastoma 2 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung cancer 2 | 4,740
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
non-small cell lung cancer 2 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primitive neuroectodermal tumor 2 | 3,035
Amelogenesis imperfecta 1 | 29
Astrocytoma, Pilocytic 1 | 3,081
Cancer 1 | 2,499
Colorectal Neoplasms 1 | 243
Congenital hypothyroidism 1 | 26
Corneal disease 1 | 31
Dental caries 1 | 164
Dental fluorosis 1 | 20
Endogenous depression 1 | 8
Goiter 1 | 38
Hydrolethalus syndrome 1 | 128
Hypothyroidism 1 | 122
Kidney cancer 1 | 2,613
Metaphyseal dysplasia 1 | 11
Osteopetrosis 1 | 43
Parkinson's disease 1 | 392
Pick disease 1 | 1,894
Renal fibrosis 1 | 6
Robinow syndrome 1 | 11
Thyroglobulin synthesis defect 1 | 1
Thyroid Dyshormonogenesis 1 1 | 6
Thyroid Dyshormonogenesis 5 1 | 1
Tooth erosion 1 | 4
Vulvitis 1 | 4
active Crohn's disease 1 | 922
active ulcerative colitis 1 | 764
adrenocortical carcinoma 1 | 1,428
adult high grade glioma 1 | 3,801
astrocytic glioma 1 | 2,597
colon cancer 1 | 1,478
diabetes mellitus 1 | 1,728
esophageal adenocarcinoma 1 | 737
gastric cancer 1 | 459
group 4 medulloblastoma 1 | 1,855
head and neck cancer 1 | 271
hepatocellular carcinoma 1 | 547
interstitial cystitis 1 | 2,312
invasive ductal carcinoma 1 | 2,951
juvenile dermatomyositis 1 | 1,187
non primary Sjogren syndrome sicca 1 | 891
oligodendroglioma 1 | 2,850
pancreatic cancer 1 | 2,398
pediatric high grade glioma 1 | 1,064
ulcerative colitis 1 | 1,819
uncontrolled asthma 1 | 56
urothelial carcinoma 1 | 318

Tissue

Blood and immune system 7 | 16,909
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Cardiovascular System 5 | 15,192

Target Family

Non-IDG 3 | 12,091
Enzyme 2 | 4,145
Kinase 1 | 634
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoredoxin NXN Tbio Non-IDG -2.54390 345.4 96
Homeobox protein BarH-like 2 BARX2 Tbio Transcription Factor -1.17761 19.7 66
Leucine-rich repeat serine/threonine-protein kinase 1 LRRK1 Tbio Kinase -1.33128 18.1 134
E3 ubiquitin-protein ligase SMURF2 SMURF2 Tbio Enzyme -1.86833 75.9 222
Programmed cell death protein 2 PDCD2 Tbio Non-IDG -1.28803 22.0 68
Dual oxidase maturation factor 2 DUOXA2 Tbio Enzyme -1.35199 19.7 84
Tuftelin TUFT1 Tbio Non-IDG -1.47826 31.1 94