Development Level

Tbio 25 | 11,445
Tchem 4 | 1,598
Tdark 4 | 6,588

IMPC Phenotype

abnormal craniofacial morpholo... 33 | 33
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 21 | 11,493
ovarian cancer 19 | 8,520
osteosarcoma 15 | 7,950
medulloblastoma, large-cell 14 | 6,241
atypical teratoid / rhabdoid tumor 11 | 5,112
ependymoma 11 | 4,679
glioblastoma 11 | 5,792
group 3 medulloblastoma 11 | 4,104
lung cancer 11 | 4,740
Breast cancer 10 | 3,578
psoriasis 10 | 6,694
astrocytic glioma 8 | 2,597
breast carcinoma 8 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
oligodendroglioma 8 | 2,850
primitive neuroectodermal tumor 8 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
invasive ductal carcinoma 7 | 2,951
Pick disease 6 | 1,894
acute myeloid leukemia 6 | 783
astrocytoma 6 | 1,146
ductal carcinoma in situ 6 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
pancreatic cancer 6 | 2,398
Astrocytoma, Pilocytic 5 | 3,081
Cancer 5 | 2,499
adrenocortical carcinoma 5 | 1,428
adult high grade glioma 5 | 3,801
non-small cell lung cancer 5 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
spina bifida 5 | 1,074
ulcerative colitis 5 | 1,819
Cognitive delay 4 | 608
Epilepsy 4 | 792
Global developmental delay 4 | 608
Intellectual disability 4 | 1,016
Mental and motor retardation 4 | 608
colon cancer 4 | 1,478
dermatomyositis 4 | 966
interstitial cystitis 4 | 2,312
lung adenocarcinoma 4 | 2,716
lung carcinoma 4 | 2,843
malignant mesothelioma 4 | 3,232
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109
Autosomal recessive predisposition 3 | 1,442
Dull intelligence 3 | 645
Hydrocephalus 3 | 152
Kidney cancer 3 | 2,613
Liver cancer 3 | 604
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Microcephaly 3 | 166
Microphthalmia 3 | 76
Poor school performance 3 | 645
Seizures 3 | 596
chronic rhinosinusitis 3 | 512
cystic fibrosis 3 | 1,696
esophageal adenocarcinoma 3 | 737
group 4 medulloblastoma 3 | 1,855
nasopharyngeal carcinoma 3 | 1,058
sonic hedgehog group medulloblastoma 3 | 467
Alzheimer's disease 2 | 658
Atopic dermatitis 2 | 952
Cervical cancer 2 | 24
Coloboma 2 | 51
Congenital heart disease 2 | 93
DiGeorge syndrome 2 | 47
Goldenhar syndrome 2 | 20
High forehead 2 | 102
Hydrolethalus syndrome 2 | 128
Hypospadias 2 | 53
Imperforate anus 2 | 25
Infantile onset 2 | 238
Liver Cirrhosis, Experimental 2 | 769
Long face 2 | 71
Low compliance bladder 2 | 11
Low set ears 2 | 181
Multiple myeloma 2 | 1,332
Muscle hypotonia 2 | 571
Neuropathy 2 | 261
Nonsyndromic deafness 2 | 142
Opitz-GBBB syndrome 2 | 18
Polydactyly 2 | 107
Rheumatoid arthritis 2 | 1,191
Small head 2 | 374
Smooth philtrum 2 | 43
Tall forehead 2 | 102
Thrombophlebitis 2 | 19
Velocardiofacial syndrome 2 | 46
atypical teratoid/rhabdoid tumor 2 | 357
diabetes mellitus 2 | 1,728
gastric carcinoma 2 | 807
glioblastoma multiforme 2 | 142
juvenile dermatomyositis 2 | 1,187
pancreatic carcinoma 2 | 562
tuberculosis 2 | 2,010
Serine deficiency 1 | 9

Tissue

Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Cardiovascular System 31 | 15,192
Liver and Pancreas 31 | 16,750

Target Family

Non-IDG 16 | 12,091
Enzyme 9 | 4,145
Transcription Factor 4 | 1,400
Epigenetic 3 | 242
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lysosomal-associated transmembrane protein 4B LAPTM4B Tbio Non-IDG -1.90763 86.1 91
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Biogenesis of lysosome-related organelles complex 1 subunit 2 BLOC1S2 Tbio Non-IDG -2.89123 759.6 79
Metal regulatory transcription factor 1 MTF1 Tbio Transcription Factor -1.98140 101.0 135
Cat eye syndrome critical region protein 2 CECR2 Tchem Epigenetic -2.17030 147.0 44
Nucleoredoxin NXN Tbio Non-IDG -2.54390 345.4 96
Nucleoside diphosphate kinase 7 NME7 Tbio Enzyme -0.83479 6.29 113
Methylmalonic aciduria and homocystinuria type C protein MMACHC Tbio Non-IDG -1.83573 76.5 233
Anaphase-promoting complex subunit 15 ANAPC15 Tdark Enzyme -0.41378 2.22 27
Ras-related protein Rab-34 RAB34 Tbio Enzyme -1.77250 102.9 72