Development Level

Tbio 26 | 11,445
Tdark 3 | 6,588
Tchem 2 | 1,598

Collection

Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

abnormal cornea morphology 31 | 31
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 26 | 11,493
osteosarcoma 18 | 7,950
ovarian cancer 15 | 8,520
atypical teratoid / rhabdoid tumor 13 | 5,112
glioblastoma 13 | 5,792
psoriasis 13 | 6,694
lung cancer 12 | 4,740
medulloblastoma, large-cell 12 | 6,241
Kidney cancer 9 | 2,613
ependymoma 8 | 4,679
group 3 medulloblastoma 8 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
lung adenocarcinoma 8 | 2,716
malignant mesothelioma 8 | 3,232
primitive neuroectodermal tumor 8 | 3,035
Breast cancer 7 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
invasive ductal carcinoma 6 | 2,951
lung carcinoma 6 | 2,843
Cancer 5 | 2,499
Pick disease 5 | 1,894
astrocytic glioma 5 | 2,597
ductal carcinoma in situ 5 | 1,745
non-small cell lung cancer 5 | 2,890
oligodendroglioma 5 | 2,850
spina bifida 5 | 1,074
Astrocytoma, Pilocytic 4 | 3,081
Down syndrome 4 | 499
Liver cancer 4 | 604
Schizophrenia 4 | 1,160
acute quadriplegic myopathy 4 | 1,158
adrenocortical carcinoma 4 | 1,428
adult high grade glioma 4 | 3,801
group 4 medulloblastoma 4 | 1,855
juvenile dermatomyositis 4 | 1,187
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Anemia 3 | 365
Atopic dermatitis 3 | 952
Autosomal recessive predisposition 3 | 1,442
Craniosynostosis 3 | 74
Intellectual disability 3 | 1,016
Multiple myeloma 3 | 1,332
Muscle Spasticity 3 | 195
Muscle hypotonia 3 | 571
Rheumatoid arthritis 3 | 1,191
acute myeloid leukemia 3 | 783
astrocytoma 3 | 1,146
cutaneous lupus erythematosus 3 | 1,057
cystic fibrosis 3 | 1,696
mucosa-associated lymphoid tissue lymphoma 3 | 484
progressive supranuclear palsy 3 | 676
tuberculosis and treatment for 6 months 3 | 409
Alzheimer's disease 2 | 658
Big calvaria 2 | 147
Bipolar Disorder 2 | 666
Broad forehead 2 | 59
Cognitive delay 2 | 608
Crohn's disease 2 | 321
Developmental regression 2 | 95
Diabetes Mellitus, Type 2 2 | 142
Electroencephalogram abnormal 2 | 101
Endometrial cancer 2 | 311
Epilepsy 2 | 792
Global developmental delay 2 | 608
Immune system cancer 2 | 140
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Liver diseases 2 | 87
Loss of developmental milestones 2 | 95
Mental and motor retardation 2 | 608
Mental deterioration in childhood 2 | 95
Neurodevelopmental regression 2 | 95
Nystagmus 2 | 317
Optic Atrophy 2 | 242
Orbital separation excessive 2 | 244
Prostate cancer 2 | 175
Prostatic Neoplasms 2 | 495
Psychomotor regression 2 | 95
Psychomotor regression beginning in infancy 2 | 95
Psychomotor regression in infants 2 | 95
Psychomotor regression, progressive 2 | 95
Seizures 2 | 596
active ulcerative colitis 2 | 764
aldosterone-producing adenoma 2 | 665
atypical teratoid/rhabdoid tumor 2 | 357
chronic rhinosinusitis 2 | 512
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
interstitial cystitis 2 | 2,312
posterior fossa group B ependymoma 2 | 416
primary pancreatic ductal adenocarcinoma 2 | 1,109
substance-related disorder 2 | 162

Tissue

Blood and immune system 31 | 16,909
Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Female tissues 31 | 17,400
Liver and Pancreas 31 | 16,750
Male tissues 31 | 17,142
Respiratory system 31 | 16,393
Skin and soft tissues 31 | 17,230
Urinary Tract 31 | 16,678
Nervous System 30 | 16,725
Cardiovascular System 29 | 15,192

Target Family

Non-IDG 19 | 12,091
Enzyme 5 | 4,145
Transcription Factor 4 | 1,400
Epigenetic 1 | 242
Ion Channel 1 | 344
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
PR domain zinc finger protein 4 PRDM4 Tbio TF/Epigenetic -0.87918 7.84 221
Ras-related protein Rab-19 RAB19 Tdark Enzyme -0.54731 3.31 75
Unconventional myosin-X MYO10 Tbio Non-IDG -1.49855 36.4 47
Protein spinster homolog 2 SPNS2 Tbio Non-IDG -1.42853 26.4 88
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 AGAP1 Tbio Enzyme -0.83079 8.71 94
Ephrin-A4 EFNA4 Tbio Non-IDG -1.23647 17.4 213
ETS domain-containing protein Elk-4 ELK4 Tbio Transcription Factor -1.07328 11.4 100
Homeobox protein BarH-like 2 BARX2 Tbio Transcription Factor -1.17761 19.7 66
Structure-specific endonuclease subunit SLX4 SLX4 Tbio Enzyme -1.68794 61.7 56
Peroxisomal biogenesis factor 3 PEX3 Tbio Non-IDG -1.79362 72.7 79